劉校生
(Hsiao-Sheng Liu, Ph.D.)

Professional address:

Department of Microbiology and Immunology

College of Medicine National Cheng Kung University

Home address:

#58, Lane 93, Tong-Ning Road

Tainan, TAIWAN

Republic of China

E-mail: a713@mail.ncku.edu.tw

Personal Data

Birth date and place: July 13, 1953, Taiwan, R. O. C.

Married

Nationality: Taiwan, R. O. C.

______________________________________________________________________________________________________

PROFESSIONAL EXPERIENCE

Since Aug. 1998 – present        Professor Department of Microbiology & Immunology National Cheng Kung University

Aug. 1991 - July 1998              Associate Professor Department of Microbiology & Immunology National Cheng Kung University

Dec. 1990 - July 1991              Research Assistant Professor Department of Anatomy & Cell biology University of Cincinnati

Oct. 1988 - Nov. 1990            Research Associate Department of Anatomy & Cell biology University of Cincinnati

May 1987 - Sept. 1988            Post-Doc. Assistant Department of Anatomy & Cell biology University of Cincinnati

Jan. 1983 - May 1986              Research Assistant Virology Laboratory Texas Tech University

Jan. 1977 - Dec. 1982             Teaching Assistant Department of Entomology National Chung Hsing University

 

Publication (1989-2008):

1.       Liu, H. S*., Lee, Y. R., Chia-Lun Chang, C. L., and Tsuey-Yu Chang, T. Y. 2008. The dengue virus-induced autophagy. Research Signpost (in press)

2.       Lee, J. C., Won, S. J., Chao, C. L., Wu, F. L., Liu, H. S., Ling, P., Lin, C. N., and Su, C. L. 2008. Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. Biochem. Biophys. Res. Comm. 372, 236–242.

3.          Lee, Y. R., Lei, H. Y., Wang, J. R., Chen, S. H., Jiang-Shieh, Y. F., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*. Autophagic machinery activated by dengue virus enhances virus replication. 2008. Virology 374, 240-248.

4.          Yeh, H. H., Wu, C. H., Raghavaraju, G., Kato, K., Kohno, K., Izum, H., Chou, C. Y., Wu-Chou Su, W. C. and Liu, H. S*. 2008. Oncogenic Ras induced morphological change is through MEK/ERK signaling pathway to down-regulate Stat3 at post-translational level in NIH3T3 cells. Neoplasia 10, 52-60.

5.          Lin, C. F, Lei, H. Y., Liu, C. C., Liu, H. S. Yeh, T. M., Anderson, R., and Lin, Y. S. 2008. Patient and Mouse Antibodies against Dengue Virus Nonstructural Protein 1 Cross-React with Platelets and Cause Their Dysfunction or Depletion. Americ. J. Infect. Dis., 4, 69-74.

6.          Lee, Y. R., Lei, H. Y., Chen, S. H., Wang, J. R., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*. 2008. Signaling pathways involved in dengue-2 virus infection induced RANTES over-expression. Americ. J. Infect. Dis., 4, 32-40.

7.          Lee, Y. R., Hung, N. T., Liu, C. C., Huang, K. J., Lei, H. Y., Lin, Y. S., Wang, J. R., Yeh, T. M., Chen, S. H., and Liu, H. S*.  2008. Correlation of IFN-inducible protein 10 levels in sera with disease severity and clinical outcome of the dengue patients. Americ. J. Infect. Dis., 4, 18-21.

8.          Lee, Y. R., Su, C. Y., Chow, N. H., Lai, W. W., Lei, H. Y.,  Chang, C. L., Chang, T. Y., Chen, S. H., Lin, Y. S., Yeh, T. M., and Liu, H. S*.  2007. Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res. 126, 216-225.

9.          Tsai, P. C., Ko, Y. C., Huang, W., Liu, H. S., and Guo, Y. L. 2007. Increased liver and lupus mortalities in 24-year follow-up of the Taiwanese people highly exposed to polychlorinated biphenyls and dibenzofurans. Sci Total Environ. 374, 216-222.

1.          Wu, T. F., Wu, H. , Wang, I. W., Chang, T. Y., Chan, S. H., Lin, Y. P.,  Liu, H. S. * , and Chow, N. H. * 2007. Prohibitin in the pathogenesis of transitional cell bladder cancer. Anticancer Res. 27, 895-900.

2.          Chang, C. P., Yang, M. C., Liu, H. S., Lin, Y. S., and Lei, H. Y. 2007. Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology 45, 286-296.

3.          Lee, Y. R., Liu, M. T., Lei, H. Y., Liu, C. C., Wu, J. M., Tung, Y. C. Lin, Y. S., Yeh, T. M., Chen, S. H., and Liu, H. S.*  2006. MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol. 87, 3623-3630.

4.          Hsu, P. Y., Liu, H. S., Cheng, H. L., Tzai, T. S., Guo, H. R., Ho, C. L., and Chow, N. H. 2006. Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis. J. Urol. 176, 2262-2267.

5.          Yeh, H. H., Lai, W. W., Chen, H. H. W., Liu, H. S.*, and Su, W. C.* 2006. Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 25; 4300-4309.

6.          Tseng, Y. S., Tzeng, C. C., Huang, C. Y. F., Chen, P. H., Chiu, Allen W. H., Hsu, P. Y., Huang G. C., Wang, Y. C., and Liu, H. S. * 2006. Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett., 241, 93-101.

7.          Lin, Y. S., Su, L. J., Yu, C. T., Wong, F. H., Yeh, H. H., Chen, S. L., Wu, J. C., Lin, W. J., Shiue, Y. L., Liu, H. S., Hsu, S. L., Lai, J. M., and Huang, C. Y. 2006. Gene expression profiles of the aurora family kinases. Gene Expr. 13, 15-26.

8.          Huang, K. J., Yang, Y. C., Lin, Y. S., Huang, J. H., Liu, H. S., Yeh, T. M., Chen, S. H., Liu, C. C., and Lei, H. Y. 2006. The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol. 176, 2825-32.

9.          Chen, L. C., Lei, H. Y., Liu, C. C., Shiesh, S. C., Chen, S. H., Liu, H. S., Lin, Y. S., Wang, S. T., Shyu, H. W., and Yeh, T. M. 2006. Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg. 74,142-147.

10.      Chou, C. K., Liang, K. H., Tzeng, C. C., Huang, G. C., Chuang, J. I., Chang, T. Y., and  Liu, H. S. * 2006. Dominant negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFκB in Ha-ras oncogene-transformed NIH/3T3 cells. Life Sci., 78, 1823-9.

11.      Lee, Y. R., Huang, K. J., Lei, H. Y., Chen, S. H., Lin, Y. S., Yeh, T. M., and Liu, H. S. * 2005. Establishment of a suckling mice system to screen and produce infectious dengue-2 viruses from full-length cDNA. Intervirology 48, 161-166.

12.      Cheng, H. L., Liu, H. S., Lin, Y. J., Chen, H. H. W., Hsu, P. Y., Chang, T. Y., Ho, C. L., Tzai, T. S., and Chow, N. H. 2005. Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. Brit. J. Cancer 92, 1906-1914. (First author)

13.      Wu, T. F., Wu, H., Chow, N. F., Liao, C. F., and Liu, H. S. * 2005. Proteomic analysis of bladder cancer cells reveals potential candidates of biomarkers in bladder tumorigenesis. Cancer Genom. Proteom. 2, 151-158.

14.      Chen, S. W., Hwang, W. S., Tsao, C. J., Liu, H. S., and Huang, G. C. 2005. Hydroxyurea and splenic irradiation-induced tumour lysis syndrome: a case report and review of the literature. J Clin Pharm Ther. 30, 623-5.

15.      Cheng, J.C., Liu, H.S., Wu, J.K., Chung, H.W. and Jan, G.J.  2005. Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease.  Int. J. Radiat. Oncol. Biol. Phys. 62, 1150-1156.

16.      Li, Y.T., Liu, H.S., Lin, H.P. and Chen, S.H. 2005. Gold nanoparticles for microfluidics-based biosensing of PCR products by hybridization-induced fluorescence quenching. Electrophoresis 26, 4743-50.

17.      Chen, C. Y., Liu, H. S., and Lin, X. Z. 2005. Hydrodynamics-based gene delivery to the liver by bile duct injection of plasmid DNA – the impact of lasting biliary obstruction and injection volume. Hepato-Gastroenterology 52, 25-28.

18.      Yen, K.H., Lee, C., Liu, H.S. and Ho, C.L. 2005. A precise and scalable method for querying genes in chromosomal banding regions based on cytogenetic annotations. Bioinformatics 21, 3469-3474.

19.      Liao, C.S., Lee, G.B., Liu, H.S., Hsieh, T.M. and Luo, C.H.  2005. Miniature RT-PCR system for diagnosis of RNA-based viruses.  Nucleic Acids Res.  33, e156.

20.      Li, M., Lin, Y.C., Wu, C.C. and Liu. H.S. 2005. Enhancing the efficiency of a PCR using gold nanoparticles. Nucleic Acids Res. 33, e184.

21.      Chan, S.H., Chen, L.J., Chow, N.H. and Liu, H.S.  2005. An ancova approach to normalize microarray data, and its performance to existing methods.  J. Bioinform. Comput. Biol.  3, 257-268.

22.      Huang, H. M., Yu, W. L., Huang, Y. L., Hwang, W. S., Tsao, C. J., Liu, H. S., and Huang, G. C. 2005. Aplastic anemia associated with dyskeratosis congenita treated with antilymphocyte globulin and cyclosporine: a case report. Chin. Med. J. 118, 790-792.

23.      Lee, J.C., Lee, C.H., Su CL.  Huang, C.W., Liu, H.S., Lin, C.N. and Won, S.J.   2005. Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.  Carcinogenesis.  26, 1716-1730.

24.      Dai, Y. C., Ho, C. L., Tsai, Y. C., Hsu, Y. H., Chang, Y. C., Liu, H. S., Chen, H. W., and Chow, N. H. 2005. Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval. J. Cancer Res. Clin. Oncol. 131, 94-100.

25.      Huang, T.J., Lu, C.C., Tsai, J.C.  Yao, W.J., Lu, X., Lai, M.D., Liu, H.S. and Shiau, A.L.  2005. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression.  J. Biol. Chem.  280(30), 27742-27754.

26.      Su S. J., Yeh, T. M., Chuang, W. J., Ho, C. L., Chang, K. L., Cheng, H. L., Liu, H. S., Cheng H. L., Hsu P. Y., and Chow N. H. 2005. The Novel Targets for Anti-angiogenesis of Genistein on Human Cancer Cells. Biochem Pharmacol 69, 307-18.

27.      Lin, C. F, Chiu, S. C., Hsiao, Y. L., Wan, S. W., Lei, H. Y., Shiau, A. L., Liu, H. S. Yeh, T. M., Chen, S. H., Liu, C. C., and Lin, Y. S. 2005. Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J. Immunol. 174, 395-403.

28.      Lin, Y. S., Lin, C. F., Lei, H. Y., Liu, H. S. Yeh, T. M., Chen, S. H., and Liu, C. C. 2004. Antibody-mediated endothelial cell damage via nitric oxide. Curr Pharm Des. 10, 213-221.

29.      Lin, C. F., Lei, H. Y., Liu, C. C., Liu, H. S., Yeh, T. M., Chen, S. H., and Lin, Y. S. 2004. Autoimmunity in dengue virus infection. Dengue Bulletin 28, 51-57.

30.      Cuang, K. P., Huang, Y. F., Hsu, Y. L., Liu, H. S., Chen, H. C., and Shieh, C. C. 2004. Ligation of lymphocyte function-associated antigen-1 on monocytes decrases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway. Blood 104, 4046-4053.

31.      Tsai W. C., Tsai S. T., Ko J. Y., Jin Y. T., Li C, Huang W, Young K. C., Lai M. D., Liu, H. S., and Wu L. W. 2004. The mRNA profile of genes in betel quid chewing oral cancer patients. Oral Oncol. 40:418-26.

32.      Chuang, J. I., Chang, T. Y., and Liu, H. S. * 2003. Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin. Oncogene. 22, 1349-1357.

33.      Wen, Y. Y., Chang, T. Y., Chen, S. T., Li, C., and Liu, H. S. 2003. Comparative study of enterovirus 71 infection of human cell lines. J. Med. Virol. 70, 109-118.

34.      Tseng, Y. T., Tzeng, C. C., Chiu, W. H., Lin, C. H., Won; S. J., Wu, I. C., and Liu, H. S. * 2003. Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil. Exp. Cell Res., 288, 403-414.

35.      Chang, T. Y., Tsai, W. J., Chou, C. K., Chow, N. H., Leu, T. H., and Liu, H. S. * 2003. Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells. Life Sci., 73, 1265-1274.

36.      Huang Y. H., Lei H. Y., Liu, H. S., Lin Y. S., Chen S. H., Liu C. C., and Yeh T.M. 2003. Tissue plasminogen activator induced by dengue virus infection of human endothelial cells. J Med Virol. 70, 610-616.

37.      Hsieh, C. C., Lin, W. C., Lee, M. R., Hsu, S. L., Liu, H. S., Kao, S. T., and Hsieh, M. T. 2003. Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice. Immunopharm. Immunotox. 25, 250-271.

38.      Lin C. F., Lei H. Y., Shiau A. L., Liu C. C., Liu, H. S., Yeh T. M., Chen S. H., and Lin Y. S. 2003. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol. 69, 82-90.

39.      Lin, Y. L., Lei, H. Y., Lin, Y. S., Yeh, T. M., Chen, S. H., and Liu, H. S. * 2002. Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res. 56, 93-96.

40.      Lin, C. F., Lei, H. Y., Shiau, A. L., Liu, H. S., Yeh, T. M., Chen, S. H., Liu, C. C., Chiu, S. C., and Lin, Y. S. 2002. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J. Immunol. 169, 657-664.

41.      Cheng, H. L., Trind, B., Tzai, T. S., Liu, H. S., Chan, S. H., Ho, C. L., Sidransky, D., and Chow, N. H. 2002. Overexpression of c-met as a prognostic indicator for transitional cell carcinoma of the urinary bladder. A comparison with p53 nuclear accumulation. J. Clin. Oncol. 20, 1544-1550.

42.      Liu, C. C., Huang, K. J., Lin, Y. S., Yeh, T. M., Liu, H. S., and Lei, H. Y., 2002. Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. J Med Virol. 68, 241-52.

43.      Lin, Y. W., Wang, K. J., Lei, H. Y., Lin, Y. S., Yeh, T. M., Liu, H. S., Liu, C. C., and Chen, S. H. 2002. Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J. Virol. 76, 12242-12249.

44.      Guo, Y. L., Chang, S. C., Tsai, R. H., Huang, J. C., Li, C., Young, K. C., Wu, L. W., Lai, M. D., Liu, H. S. and Huang, W. 2002. Two UVC-induced stress response pathways in HeLa cells identified by cDNA microarray.  Environ. Mol. Mutag., 40, 122-128.

45.      Wang, C. H., Tsai, L. J., Tsao, Y. P., Hsieh, J. T., Chien, W. W., Liao, C. L., Wang, H. W., Liu, H. S., and Chen, S. L., 2002. Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase-5 and mitochondria-dependent pathways. Biochem. Biophys. Res. Comm. 298, 805-814.

46.      Liu, H. S., Lee, C. H., Lee, C. F., Su, I. J., and Chang, T. Y. 2001. Lac/Tet dual-inducible system functions in mammalian cell lines. Cloning and expression vectors for gene function analysis. (editor Lu & Weiner; Biotechniques, pp254) Chapter 31, 169-179.

47.      Su, W. C., Shiesh, S. C., Liu, H. S., Chen, C. Y., Chow, N. H., and Lin, X. Z. 2001. Expression of oncogene products HER2/Neu and Ras and Fibrosis-Related Growth factors bFGF, TGF-, and PDGF in bile from biliary malignancies and inflammatory disorders.  Digest. Dis. And Sci., 46, 1387-1392.

48.      Huang, Y. H., Lei, H. Y., Liu, H. S., Lin, Y. S., Liu, C. C., and Yeh, T.M. 2001. Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am. J. Trop. Mol. Hyg., 63, 71-75.

49.      Shen, M. R., Chou, C. Y., Hsu, K. F., Liu, H. S., Dunham, P. B., Holtzman, E. J., and Ellory, J. C. 2001. The KCl cotransporter isoform KCC3 can play an important role in cell growth regulation. Proc. Natl. Acad. Sci. USA. 98, 14714-14719.

50.      Lin, C. F., Lei, H. Y., Liu, C. C., Liu, H. S., Yeh, T. M., Wang, S. T., Yang, T. I., Sheu, F. C., Kuo, C. F., and Lin, Y. S. 2001. Generation of IgM anti-platelet autoantibody in dengue patients. J. Med. Virol., 63, 143-149.

51.      Chow, N. H., Chan, S. H., Tzai, T. S., Ho, C. L., and Liu, H. S. 2001. Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin. Cancer Res., 7, 1957-1962.

52.      Huang, Y. H., Liu, C. C., Wang, S. T., Lei, H. Y., Liu, H. S., Lin, Y. S., Wu, H. L., and Yeh, T. M. 2001. Activation of coagulation and fibrinolysis during dengue virus infection. J. Med. Virol., 63, 247-251.

53.      Kao, S. T., Yeh, C. C., Hsieh, C. C., Yang, M. D., Lee, M. R., Liu, H. S., and Lin, J. G. 2001. The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci. 69, 1485–1496.

54.      Shiao, S. H., Higgs, S., Adelman, Z., Christensen, B. M., Liu, H. S., and Chen, C. C. 2001. Effect of prophenoloxidase expression knockout on the melanization of microfilariae in the mosquito Armigeres subalbatus. Insect Mol. Biol., 10, 315-321.

55.      Chen, C. C., Shieh, B., Jin, Y. T., Liau, Y. E., Huang, C. H., Liou, J. T., Wu, L. W., Huang, W., Young, K. C., Lai, M. D., Liu, H. S., and Li, C. 2001. Microarray profiling of gene expression patterns in bladder tumor cells treated with genistein. J. Biomed. Sci., 8, 214-222.

56.      Lin, Y. L., Liu, C. C., Chuang , J.I., Lei, H. Y., Yeh, T. M., Lin, Y. S., Huang Y. H., and Liu, H. S. * 2000. Involvement of oxidative stress, NF-IL-6 and RANTES expression in dengue-2 virus infected human liver cells. Virology 10, 114-126.

57.      Lin, Y. L., Lei, H. Y., Wen, Y. Y., Luh, T. Y., Chou, C. K , and Liu, H. S. * 2000. Light-independent Inactivation of Dengue-2 Virus by Carboxyfullerene C3 Isomer. Virology 275, 258-262.

58.      Lin, Y. L., Liu, C. C., Lei, H. Y., Yeh, T. M., Lin, Y. S., Chen, M. Y., and Liu, H. S. * 2000. Infection of five human liver cell lines by dengue-2 virus. J. Med. Virol. 60, 425-431.

59.      Chow N. H., Liu, H. S., and Chan, S. H., 2000. The role of nm23-H1 in the progression of transitional cell bladder cancer. Clin. Cancer Res. 6, 3595-3599.

60.      Yang, B. C., Wang, Y. S., Liu, H. S., and Lin, S. J. 2000. Ras signaling is involved in the expression of Fas-L in glioma. Laborat. Invest. 80, 529-537.

61.      Huang, K. J., Lin, S. Y., Chen, S. C., Liu, H. S., Lin, Y. S., Yeh, T. M., and Lei, H. Y., 2000. Manifestation of thrombocytopenia in dengue-2-virus-infected mice. J. Gen. Virol., 81, 2177-2182.

62.      Chow N. H., Tzai, T. S., Cheng, H. L., Liu, H. S., Chan, S. H., and Tong, Y. C. 2000. The clinical value of p21WAF1/CIP1 expression in superficial bladder cancer. Anticancer Res. 20, 1173-1176.

63.      Jan, M. S., Liu, H. S., and Lin, Y. S. 1999. Bad overexpression sensitizes NIH/3T3 cells to undergo apoptosis which involves caspase activation and ERK inactivation. Biochem. Biophys. Res. Comm. 264, 724-729.

64.      Liu, H. S., Jan, M. S., Chou, C. K., Chen, P. H., and Ke, N. J. 1999. Is Green Fluorescent Protein toxic to the living cells? Biochem. Biophys. Res. Comm. 260, 712-717.

65.      Chang, T. Y., Wen, Y. Y., Su, I. J., and Liu, H. S. * 1999. A plasmid harboring lac repressor and tTA activator genes can regulate two inducible genes in mammalian cells. Biotehcniques 27, 466-469.

66.      Chang, M. Y., Won, S. J., Yang, B. C., Jan, M. S., and Liu, H. S. * 1999. Selective activation of Ha-rasval12 oncogene increases susceptibility of NIH/3T3 cells to TNF-. Experiment. Cell Res., 248, 589-598.

67.      Chow N. H., Liu, H. S., Chan, S. H., Cheng, H. L., and Tzai, T. S. 1999. Expression of vascular endothelial growth factor in primary superficial bladder cancer. Anticancer Res. 19, 4593-4597.

68.      Liu, H. S., Lee, C. H., Lee, C. F., Su, I. J., and Chang, T. Y. 1998. A Lac/Tet dual-inducible system functions in mammalian cell lines. Biotechniques. 24, 624-632.

69.      Liu, M. F., Liu, H. S., Wang, C. R., and Lei, H. Y. 1998. Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. J. Clin. Immunol. 18, 392-398.

70.      Lai, W. W., Chen, F. F., Chen, C. Y., and Liu, H. S. 1998. Animal model of lung cancer metastasis: comparison of efficiency of propagating human lung cancer cell lines in SCID mice with intrabronchial, percutaneous intrathoracic, and subcutaneous routes. J. Surg. Assoc. ROC. 31, 90-96.

71.      Liu, H. S., Chen, C. Y., Lee, C. H., and Chou, Y. I. 1998. Selective induction of oncogenic Ha-ras induced apoptosis in NIH/3T3 cells. Brit. J. Cancer. 77, 1777-1786.

72.      Chang, M.Y., Jan, M. S., Won, S.J., and Liu, H.S. * 1998. Ha-rasval12 oncogene increases susceptibility of NIH/3T3 cells to lovastatin. Biochem. Biophys. Res. Comm. 248, 62-68.

73.      Chow, N. H., Liu, H. S., Chang, C. J., Chi, Y. C., Tzai, T. S., Li, I. C., and Lin, S. N. 1998. Urinary excretion of transforming growth factor-alpha in patients with transitional cell carcinoma. Anticancer Res. 18, 2053-2058.

74.      Chow, N. H., Cheng, C. J., Chi, Y. C., Liu, H. S., Tzai, T. S., and Lin, S. N. 1998. Potential value of urinary intercellular adhesion molecule-1 determination in patients with bladder cancer. Urology 52, 1015-1019.

75.      Su, W. C., Chow, N. H., Huang, C. H., and Liu, H. S. * 1998. Using 2-step PCR and restriction endonuclease digestion to detect K-ras mutation in paraffin-embedded tissues: Is it reliable J. Clin. Laborat. Anal. 12, 168-171.

76.      Cho, W. L., Liu, H. S., Lee, C. H., Kuo, C. C., Chang, C. I., Liu, C. T., and Chen, C. C. 1998. Molecular cloning, characterization and tissue expression of prophenoloxidase cDNA from mosquito Armigeres subalbatus inoculated with Dirofilaria immitismicr. Insect Mol. Biol. 7, 31-40.

77.      Wu. J. D., Hsueh, H. C., Huang, W. T., Liu, H. S., Leung, W. C., Ho, Y. R., Lin, M. T. and Lai, M. D. 1997. The inducible lactose operator-repressor system is functional in whole animal. DNA Cell Biol. 16, 17-22.

78.      Liu, H. S., Lin, Y. L., and Chen, C. C. 1997. Comparison of various methods of detection of different forms of dengue virus 2 RNA in cultured cells. Acta Virologica. 41, 317-324.

79.      Liu, H. S., Lin, C. N., and Wong, S. J. 1997., Antitumor activity of 2,6-di(2,3-epoxypropoxy) xanthone, a newly synthesized xanthone derivative, on a transformed NIH3T3 cell line. Anticancer Res. 17, 1107-1114.

80.      Chang, M. Y., Won, S. J., and Liu, H. S. * 1997. A ribozyme specifically suppresses transformation and tumorigenicity of Ha-ras oncogene transformed NIH-3T3 cell lines. J. Cancer Res. and Clin. Onc. 123, 91-99.

81.      Liu, H. S., and Bilimoria, S. L. 1997. Regulation of infected-cell-specific protein synthesis in SF IPLB-21 cells productively infected with Spodoptera frugiperda multicapsid nuclear polyhedrosis. Intervirol. 40, 50-54.

82.      Lin, H. H., Yang, T. P., Jiang, S. T., Liu, H. S., and Tang, M. J. 1997. Inducible expression of bcl-2 by the lac operator/repressor system in MDCK cells. Am. J. Physiol. 273, 300-306.

83.      Lee, J. Y., Pulkkinen, L., Liu, H. S., Chen, Y. F., and Uitto, J. 1997. A glycine-to-arginine substitution in the triple-helical domain of type VII collagen in a family with dominant dystrophic epidermolysis bullosa pruriginosa. J. Invest. Dermatol. 108, 947-949.

84.      Huang, Y. H., Chang, B. I., Lei, H. Y., Liu, H. S., Liu, C. C., Wu, H. L., and Yeh, T. M. 1997. Antibodies against synthetic peptide representing amino acids 100-119 of dengue virus E protein cross react with plasminogen and interfere with plasmin function. Clin. Experiment. Immunol. 110, 35-40.

85.      Chow, N. H., Liu, H. S., Yang, H. B., Chan, S. H., and Su, I. J. 1997. Expression Patterns of erbB receptor family in normal urothlium and transitional cell carcinoma: an immunohistochemical study. Virchows Arch. 430, 461-466.

86.      Chow, N. H., Liu, H. S., Lee, I. C., Chang, C. J., Chan, S. H., Cheng, H. L., Tzai, T. Z., and Lin, S. N. 1997. Significance of urinary epidermal growth factor and its receptor expression in human bladder cancer. Anticancer Res. 17, 1293-1296.

87.      Tzeng, C. C., Liu, H. S., Li, C., Jin, Y. T., Chen, R. M., Yang, W. H., and Lin, J. S. 1996. Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan. Anticancer Res. 16, 1797-1804.

88.      Liu, H. S., Tzeng, H. C., and Chen, C. C. 1995. Monitoring the cDNA synthesis of dengue-2 virus by RT PCR. J. Virol. Meth. 51, 55-60.

89.      Won, S. J., Chuang, C., Huang, W. T., Liu, H. S., and Lin, M. T. 1995. Suppression of natural killer cell activity in mouse spleen lymphocytes by several dopamine receptor antagonists. Experientia. 51, 343-348.

90.      Kuo, P. L., Wu, R.C., Tzeng, C. C., Lin, S. J., Liu, H. S., and Huang, K. E. 1995. Detection of Y-chromosomal DNA with marker chromosomes in Turner’s syndrome. J. Formos. Med. Assoc. 94, 474-480.

91.      Kuo, P. L., Wu, R.C., Lin, S. J., Tzeng, C. C., Liu, H. S., and Huang, K. E. 1995. Detection of Y-chromosome Sequences in Patients with X-chromosome Abnormalities. J. Formos. Med. Assoc. 94, 529-534.

92.      Liu, H. S., Tzeng, H. C., Liang, Y. J., and Chen, C. C. 1994. Ligation of multiple DNA fragments through uracil-DNA glycosylase generated ligation sites. Nucleic Acid. Res., 22, 4016-4017.

93.      Liu, H. S., Tzeng, H. C., Chang, T. Y., and Chen, C. C. 1994. Using a radioactive and non-radioactive exchangeable labeling system for laboratory diagnosis. The Kaohsiung J. Medical Science. 10, 165-169.

94.      Chen S. L., Tsao, Y. P., Lee, J. W., Liu, H. S., Yang, C. M., and Tsao, L. T. 1994. E5a gene of human papillomavirus type 11 is required for initiation but not for maintnance of transformation in NIH 3T3 cells. J. Gen. Virol. 75, 1953-1960.

95.      Liu, H. S., Scrable, H., Villaret, D. B., Lieberman, M. A., and Stambrook, P. J. 1992. Control of Ha ras mediated mammalian cell transformation by E. coli regulatory elements. Cancer Res., 52, 983-989.

96.      Liu, H. S., and Bilimoria, S. L. 1990. Infected Cell Specific Protein and Viral DNA Synthesis in Productive and Abortive Infections of Spodoptera frugiperda Nuclear Polyhedrosis Virus. Arch. Virol., 115, 101-113.

97.      Liu, H. S., Feliciano, E. S., and Stambrook, P. J. 1989. Cytochemical Observation of Regulated Bacterial -galactosidase Gene Expression in Mammalian Cells. Proc. Natl. Acad. Sci. USA. 86, 9951-9955.

98.      Dlouhy, S. R., Schaff, D. A., Trofatter, J. A., Liu, H. S., Stambrook, P. J., and Tischfield, J. A. 1989. Denaturing Gradient Gel Analysis of Single-Base Substitutions at a Mouse Adenine Phosphoribosyl transferase Splice Acceptor Site. Molecular Carcinogenesis. 2, 217-225.

99.      Kral, R. M., Liu, H. S., Phillips, S. A., Bartell, D. P., and Billimoria, S. L. 1986. In vitro maintenance of ovaries and ovarian cells from Solenopsis invicta (Hymenoptera: Formicidae). J. Kansas Entomol. Soc. 59, 737-740.

100.  Liu, H. S., and Hou, R. F. 1985. Studies on inhibition with nuclear polyhedrosis virus by an ecdysteroid-containing agent in the silkworm Bombyx mori L. Chinese J. Entomol. 5, 23-30.

101.  Liu, H. S., and Hou, R. F. 1983. Electron microscopic observations on infection of nuclear polyhedrosis virus in the silkworm, Bombyx mori. Proc. Nation. Sci. Counc. Part B: 7, 51-56.

 

發明專利

1.          林忠男，翁舷誌，劉校生，劉崇喜，1993‑2013，一種新奇妙腫瘤之黃環酮化物 ,日本專利，專利號碼特許久第255444號.

2.          林忠男，翁舷誌，劉校生，劉崇喜，1998-2015，台產新靈芝等相關藥用資源 合成Xanthones抗癌物質之開發研究，美國專利，專利權號數:發明第5741813號

3.          林忠男，翁舷誌，劉校生，劉崇喜，1999‑2017，台產新日本靈芝等相關藥用資源及合成Xanthones之抗癌物質之開發研究，美國專利，專利權號數:發明第 5981774號。