楊倍昌 (Bei-Chang Yang, Ph.D.)

    台南市大學路1號, 成大醫學院;
    電話(公): 886-6--2353535 ext 5637
    傳真:886-6-2082705
    電子郵件: y1357@mail.ncku.edu.tw
    現職年月：教授(2000/08-) 兼微免所所長(2006/08-)

BCY home page 楊倍昌個人首頁

Update: 14 Aug. 2006

小檔案 

 
   學歷：
   *   德國杜賓根大學自然科學博士; Doktor der Naturwissenschaft, magna cum laude (1984-1989)
   *   中興大學植病學碩士 (1979-1981)
   *   中興大學植病學學士 (1975-1979)
   *   高雄中學 (1976-1979)
   *   高雄苓雅國中 (1973-1976)
   *   高雄成功國小 (1967-1973)
 
   經歷：

   *  成功大學醫學院視聽中心主任 (2003-2005)
   *  成功大學生物科技中心執行秘書 (2002-2003)
   *  成功大學微免所副教授 (1992-2000)
   *  中研院研究分生所博士後副研究員 (1990-1992)
   *  中研院研究助理 (1983-1984)
 
   專長學門：
   分子生物學; 腫瘤免疫; 自體免疫; 微生物學

參與開授課程

上課資料: 分子生物學; 細菌生理與遺傳; 生物科學的理則;人造抗體; 醫用微生物; 生物科學史...


研究興趣


My interest is focused on tissue specific immunity and immune dysregulation in autoimmune diseases and tumor formation.
Following are research projects currently been carried out in my laboratory:

1. Analysis of intracellular signals leading to the expression of IL-10 and Fas-L.
2. Searching for agents potent in manipulating the Th1/2 activities.
3. Study on the molecular mechanism of tumor immune escape.
4. Cell apoptosis.
5. Fas-L on tumor formation.
6. Extracelullar matrix and immune responses

　

近五年文章作品

 

 

完成式


Cheng YJ, Yang BC, and Liu MY (2006) Lead Increases Lipopolysaccharide-Induced Liver Injury Through Tumor Necrosis Factor-alfa Overexpression by Monocytes/Macrophages: Role of Protein Kinase C and P42/44 Mitogen-Activated Protein Kinase. Exp. Health Persp. In press. SCI

Liu MY, Chen JK, Cheng YJ, and Yang BC (2005) Co-exposure of lead and lipopolysaccharide-induced liver injury in rats: involvement of nitric oxide-initiated oxidative stress and TNF-alfa. Shock 23:360-364. SCI

Cheng YJ, Liu MY, Wu TP, and Yang BC (2004) Regulation of tumor necrosis factor-a in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway. Toxicol. Letters 152:127-137 (corresponding author) SCI

Wu MH, Yang BC, Lee YC, Wu PL, Hsu CC (2004) The differential expression of intercellular adhesion molecule-1 (ICAM-1) and regulation by interferon-gamma during the pathogenesis of endometriosis. Am J Reprod Immunol. 51:373-380. SCI

Lin CC, Chou CW, Shiau AL, Tu CF, Ko TM, Chen YL, Yang BC, Tao MH, and Lai MD (2004) Therapeutic HER2/Neu DNA Vaccine Inhibits Mouse Tumor Naturally Overexpressing Endogenous Neu. Mol Ther. 10:290-301. SCI

Chen YH, Wu HL, Chen CK, Huang YH, Yang BC, and Wu LW. (2003) Angiostatin antagonizes the action of VEGF-�� in human endothelial cells via two distinct pathways. Biochem. Biophy. Res. Commun. 310:804-810. SCI

Yang BC, Hor WS, Lin HK, Hwang JY, Lin YP, Liu MY, and Wang YJ (2003) Stimulation of IL-10 expression in T cell lines upon contact with human glioma cells, that is mediated by Fas signaling through a PKA-independent pathway. J. Immunol. 171:3947-3954. (corresponding author) SCI.

Chen YL, Chen SH, Wang JY, and Yang BC (2003) FasL on tumor cells mediates inactivation of neutrophils. J. Immunol. 171:1183-1192. (corresponding author) SCI

Hor WS, Huang WL, Lin YS, and Yang BC (2003) Crosstalk between tumor cells and neutrophils through the Fas (APO-1, CD95)/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils. J. Leukocyte Biol. 73: 363-368. (corresponding author) SCI

Cheng YJ, Yang BC, Hsieh WC, Huang BM, and Liu MY (2002) Enhancement of TNF-alpha expression does not trigger apoptosis upon exposure of glial cells to lead and lipopolysaccharide. Toxicol. 178:183-191. SCI

Chen YL, Wang JY, Chen SH, and Yang BC (2002) Granulocytes mediates the Fas-L-associated apoptosis during lung metastasis of melanoma that determines the metastatic behavior. Br. J. Cancer 87:359-365. (corresponding author) SCI

Chio CC, Wang YS, Chen YL, Lin SJ, and Yang BC (2001) Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis, tumor infiltrating cells, and liver damage but accelerates tumor formation in nude mice. Br. J. Cancer 85:1185-1192. (Oct). (corresponding author) SCI

Lin SH, Huang HJ, Yang BC, and Kuo TT (2001) The Increase of RNA Polymerase Activity Induced by UV-Irradiation in Xanthomonas oryzae pv. oryzae. Curr Microbiol. 43120-123. (Aug) SCI

Liu MY, Lai HY, Yang BC, Tsai ML, Yang HY, and Huang BM (2001) The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. Life Sci. 68:849-859. (Jan) SCI

Yang BC, Wang YS, HS Liu, and Lin SJ (2000) Ras signaling is involved in the expression of Fas-L in glioma. Lab. Invest. 80:529-537. (Apr) SCI

Fang SY and Yang BC (2000) Overexpression of Fas-Ligand in human nasal polyps. Ann Otol Rhinol Laryngol. 109:267-270. (Mar) SCI

Liu MY, Hsieh WC, and Yang BC (2000) In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells. Toxicol. 147:59-64. (corresponding author) SCI