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個人資料 |
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姓 名 |
劉校生 |
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E – Mail |
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辦公室電話 |
886-6-2353535 ext. 5630 |
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實驗室電話 傳真電話 |
886-6-2353535 ext. 5631、5624 886-6-2082705 |
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學歷 |
1.美國德州理工大學博士 (1983-1987) 2.國立中興大學碩士 (1978-1981) 3.國立中興大學昆蟲學學士 (1972-1976) |
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現職 |
* 成功大學醫學院微生物暨免疫學研究所教授(1998~present) |
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經歷 |
* 成功大學醫學院微生物暨免疫學研究所所長及寄生蟲學科主任 (2003-2006) * 成功大學醫學院副教授 (1991-1998) * 美國Cincinnati 大學研究助理教授 (1990-1991) * 美國Cincinnati 大學研究助理 (1988-1990) |
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專長 |
腫瘤分子生物學; 分子病毒學; 遺傳工程學; 昆蟲學 |
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教授課程 |
醫學微生物、腫瘤生物學、訊息傳遞、分子生物、生物技術、通識教育 |
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研究興趣與方向 |
Ras致癌基因之研究： 1. 以可調控方式研究與Ras 相關基因BNIP3以及RbAp46基因對膀胱癌細胞增生及自體吞噬 (Autophagy) 之關係與作用機制 2. 以生物資訊為工具搜尋砷暴露誘發之膀胱癌以及皮膚癌之生物標記基因，並研究其致癌機制 3. 研究Ras與Stat-3、Aurora-A、EMP2 共同表達對癌症癌化之影響 病毒之研究： 1.
以全長cDNA為工具研究登革病毒以及腸病毒EV71型之免疫致病機轉—自體吞噬。 |
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實驗室簡介 |
專任研究助理 : 2 博士班學生 : 4 碩士班學生 : 3 見習大學生 : 2 |
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著作 |
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期刊論文 |
論文及著述 (1989-2008) 1.
Liu, H. S*., Lee, Y. R., Chia-Lun Chang, C. L., and
Tsuey-Yu Chang, T. Y. 2008. The dengue virus-induced autophagy. Research
Signpost (in press) 2.
Lee, J. C., Won, S. J., Chao, C. L., Wu, F.
L., Liu, H. S., Ling, P., Lin, C. N., and Su, C. L. 2008. Morusin
induces apoptosis and suppresses NF-kB activity in human colorectal
cancer HT-29 cells. Biochem. Biophys. Res. Comm. 372, 236–242. 3.
Lee, Y. R., Lei, H. Y., Wang, J. R., Chen,
S. H., Jiang-Shieh, Y. F., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*.
Autophagic machinery activated by dengue virus enhances virus replication.
2008. Virology 374, 240-248. 4.
Yeh, H. H., Wu, C. H., Raghavaraju, G.,
Kato, K., Kohno, K., Izum, H., Chou, C. Y., Wu-Chou Su, W. C. and Liu, H.
S*. 2008. Oncogenic Ras induced morphological change is through MEK/ERK
signaling pathway to down-regulate Stat3 at post-translational level in
NIH3T3 cells. Neoplasia 10, 52-60. 5.
Lin, C. F, Lei, H. Y., Liu, C. C., Liu, H. S. Yeh, T. M., 6.
Lee, Y. R., Lei, H. Y., Chen, S. H., Wang,
J. R., Lin, Y. S., Yeh, T. M., Liu, C. C. and Liu, H.S*. 2008.
Signaling pathways involved in dengue-2 virus infection induced RANTES
over-expression. Americ. J. Infect. Dis., 4, 32-40. 7.
Lee, Y. R., Hung, N. T., Liu, C. C., Huang,
K. J., Lei, H. Y., Lin, Y. S., Wang, J. R., Yeh, T. M., Chen, S. H., and Liu,
H. S*. 2008. Correlation of
IFN-inducible protein 10 levels in sera with disease severity and clinical
outcome of the dengue patients. Americ. J. Infect. Dis., 4, 18-21. 8.
Lee, Y. R., Su, C. Y., Chow, N. H., Lai, W.
W., Lei, H. Y., Chang, C. L.,
Chang, T. Y., Chen, S. H., Lin, Y. S., Yeh, T. M., and Liu, H. S*. 2007. Dengue viruses can
infect human primary lung epithelia as well as lung carcinoma cells, and can
also induce the secretion of IL-6 and RANTES. Virus Res. 126, 216-225. 9.
Tsai, P. C., Ko, Y. C., Huang, W., Liu,
H. S., and Guo, Y. L. 2007. Increased liver and lupus mortalities in
24-year follow-up of the Taiwanese people highly exposed to polychlorinated
biphenyls and dibenzofurans. Sci Total Environ. 374, 216-222. 10.
Wu, T. F., Wu, H. , Wang, I. W., Chang, T.
Y., Chan, S. H., Lin, Y. P., Liu,
H. S. * , and Chow, N. H. * 2007. Prohibitin in the
pathogenesis of transitional cell bladder cancer. Anticancer Res. 27,
895-900. 11.
Chang, C. P., Yang, M. C., Liu, H. S.,
Lin, Y. S., and Lei, H. Y. 2007. Concanavalin A induces autophagy in hepatoma
cells and has a therapeutic effect in a murine in situ hepatoma model.
Hepatology 45, 286-296. 12.
Lee, Y. R., Liu, M. T., Lei, H. Y., Liu, C.
C., Wu, J. M., Tung, Y. C. Lin, Y. S., Yeh, T. M., Chen, S. H., and Liu,
H. S.* 2006. MCP-1,
a highly expressed chemokine in dengue haemorrhagic fever/dengue shock
syndrome patients, may cause permeability change, possibly through
reduced tight junctions of vascular endothelium cells. J Gen
Virol. 87, 3623-3630. 13.
Hsu, P. Y., Liu, H. S., Cheng, H.
L., Tzai, T. S., Guo, H. R., Ho, C. L., and Chow, N. H. 2006. Collaboration
of RON and epidermal growth factor receptor in human bladder carcinogenesis.
J. Urol. 176, 2262-2267. 14.
Yeh, H. H., Lai, W. W., Chen, H. H. W., Liu,
H. S.*, and Su, W. C.* 2006. Autocrine IL-6-induced
Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and
malignant pleural effusion. Oncogene 25; 4300-4309. 15.
Tseng, Y. S., Tzeng, C. C., Huang, C. Y.
F., Chen, P. H., Chiu, Allen W. H., Hsu, P. Y., Huang G. C., Wang, Y. C., and
Liu, H. S. * 2006. 16.
Lin, Y. S., Su, L. J., Yu, C. T., Wong, F.
H., Yeh, H. H., Chen, S. L., Wu, J. C., Lin, W. J., Shiue, Y. L., Liu, H.
S., Hsu, S. L., Lai, J. M., and Huang, C. Y. 2006. Gene expression
profiles of the aurora family kinases. Gene Expr. 13, 15-26. 17. Huang, K. J., Yang, Y. C., Lin, Y. S., Huang, J. H., Liu, H. S.,
Yeh, T. M., Chen, S. H., Liu, C. C., and Lei, H. Y. 2006. The dual-specific binding
of dengue virus and target cells for the antibody-dependent enhancement of
dengue virus infection. J Immunol.
176, 2825-32. 18.
Chen, L. C., Lei, H. Y., Liu, C. C., Shiesh, S. C., Chen, S. H., Liu, H. S.,
Lin, Y. S., Wang, S. T., Shyu, H. W., and Yeh, T. M. 2006. Correlation of serum levels
of macrophage migration inhibitory factor with disease severity and clinical
outcome in dengue patients. Am J Trop Med
Hyg. 74,142-147. 19.
Chou, C. K., Liang, K. H., Tzeng, C. C.,
Huang, G. C., Chuang, J. I., Chang, T. Y., and Liu, H. S. * 2006.
Dominant negative Rac1 suppresses Ras-induced apoptosis possibly through
activation of NFκB in Ha-ras oncogene-transformed NIH/3T3 cells. Life
Sci., 78, 1823-9. 20.
Lee, Y. R., Huang, K. J., Lei, H. Y., Chen,
S. H., Lin, Y. S., Yeh, T. M., and Liu, H. S. * 2005.
Establishment of a suckling mice system to screen and produce infectious
dengue-2 viruses from full-length cDNA. Intervirology 48, 161-166. 21.
Cheng, H. L., Liu, H. S., Lin, Y. J.,
Chen, H. H. W., Hsu, P. Y., Chang, T. Y., Ho, C. L., Tzai, T. S., and Chow,
N. H. 2005. Co-expression of RON and MET is a prognostic indicator for
patients with transitional-cell carcinoma of the bladder. Brit. J. Cancer 92,
1906-1914. (First author) 22.
Wu, T. F., Wu, H., Chow, N. F., Liao, C.
F., and Liu, H. S. * 2005. Proteomic analysis of bladder
cancer cells reveals potential candidates of biomarkers in bladder
tumorigenesis. Cancer Genom. Proteom. 2, 151-158. 23.
Chen, S. W., Hwang, W. S., Tsao, C. J., Liu, H. S.,
and Huang, G. C. 2005. Hydroxyurea and
splenic irradiation-induced tumour lysis syndrome: a case report and review
of the literature. J Clin Pharm
Ther.
30, 623-5. 24.
Cheng, J.C., Liu, H.S., Wu, J.K.,
Chung, H.W. and Jan, G.J. 2005.
Inclusion of biological factors in parallel-architecture normal-tissue
complication probability model for radiation-induced liver disease. Int. J. Radiat. Oncol. Biol. Phys. 62,
1150-1156. 25.
Li, Y.T., Liu, H.S., Lin, H.P. and
Chen, S.H. 2005. Gold nanoparticles for microfluidics-based biosensing of PCR
products by hybridization-induced fluorescence quenching. Electrophoresis 26,
4743-50. 26.
Chen, C. Y., Liu, H. S., and Lin, X.
Z. 2005. Hydrodynamics-based gene delivery to the liver by bile duct
injection of plasmid DNA – the impact of lasting biliary obstruction and
injection volume. Hepato-Gastroenterology 52, 25-28. 27.
Yen, K.H., Lee, C., Liu, H.S. and
Ho, C.L. 2005. A precise and scalable method for querying genes in
chromosomal banding regions based on cytogenetic annotations. Bioinformatics
21, 3469-3474. 28.
Liao, C.S., Lee, G.B., Liu, H.S.,
Hsieh, T.M. and Luo, C.H. 2005.
Miniature RT-PCR system for diagnosis of RNA-based viruses. Nucleic Acids Res. 33, e156. 29.
Li, M., Lin, Y.C., Wu, C.C. and Liu.
H.S. 2005. Enhancing the efficiency of a PCR using gold nanoparticles.
Nucleic Acids Res. 33, e184. 30.
Chan, S.H., Chen, L.J., Chow, N.H. and Liu,
H.S. 2005. An ancova approach
to normalize microarray data, and its performance to existing methods. J. Bioinform. Comput. Biol. 3, 257-268. 31.
Huang, H. M., Yu, W. L., Huang, Y. L., Hwang, W. S., Tsao, C. J., Liu, H. S.,
and Huang, G. C. 2005. Aplastic anemia associated
with dyskeratosis congenita treated with antilymphocyte globulin and
cyclosporine: a case report. Chin. Med. J. 118, 790-792. 32.
Lee, J.C., Lee,
C.H., Su CL. Huang, C.W., Liu, H.S.,
Lin, C.N. and Won, S.J.
2005. Justicidin A decreases the level of cytosolic Ku70 leading to
apoptosis in human colorectal cancer cells. Carcinogenesis. 26, 1716-1730. 33.
Dai, Y. C., Ho, C. L., Tsai, Y. C., Hsu, Y.
H., Chang, Y. C., Liu, H. S., Chen, H. W., and Chow, N. H. 2005.
Allelic loss of 14q 34.
Huang, T.J., Lu, C.C., Tsai, J.C. 35.
Su S. J., Yeh, T. M., Chuang, W. J., Ho, C.
L., Chang, K. L., Cheng, H. L., Liu, H. S., Cheng H. L., Hsu P. Y.,
and Chow N. H. 2005. The Novel Targets for Anti-angiogenesis of Genistein on Human
Cancer Cells. Biochem Pharmacol 69, 307-18. 36. Lin, C. F, Chiu, S. C., Hsiao, Y. L., Wan, S. W., Lei, H. Y., Shiau, A. L., Liu, H. S. Yeh, T. M., Chen, S. H., Liu, C. C., and Lin, Y. S. 2005.
Expression of cytokine, chemokine, and adhesion molecules during endothelial
cell activation induced by antibodies against dengue virus nonstructural
protein 1. J. Immunol. 174, 395-403. 37.
Lin, Y. S., Lin, C. F., Lei, H. Y., Liu, H. S. Yeh, T. M., Chen, S. H., and Liu, C. C. 2004. Antibody-mediated
endothelial cell damage via nitric oxide. Curr Pharm Des. 10, 213-221. 38.
Lin, C. F., Lei, H. Y., Liu, C. C., Liu,
H. S., Yeh, T. M., Chen, S. H., and Lin, Y. S. 2004. Autoimmunity in
dengue virus infection. Dengue Bulletin 28, 51-57. 39.
Cuang, K. P., Huang, Y. F., Hsu, Y. L., Liu,
H. S., Chen, H. C., and Shieh, C. C. 2004. Ligation of lymphocyte
function-associated antigen-1 on monocytes decrases very late
antigen-4-mediated adhesion through a reactive oxygen species-dependent
pathway. Blood 104, 4046-4053. 40.
Tsai W. C., Tsai S. T., Ko J. Y., Jin Y.
T., Li C, Huang W, Young K. C., Lai M. D., Liu, H. S., and Wu L. W.
2004. The mRNA profile of genes in betel quid chewing oral cancer patients.
Oral Oncol. 40:418-26. 41.
Chuang, J. I., Chang, T. Y., and Liu, H.
S. * 2003. Glutathione depletion-induced apoptosis of
Ha-ras-transformed NIH3T3 cells can be prevented by melatonin. Oncogene. 22,
1349-1357. 42.
Wen, Y. Y., Chang, T. Y., Chen, S. T., Li,
C., and Liu, H. S. 2003. Comparative study of enterovirus 71 infection
of human cell lines. J. Med. Virol. 70, 109-118. 43.
Tseng, Y. T., Tzeng, C. C., Chiu, W. H.,
Lin, C. H., Won; S. J., Wu, I. C., and Liu, H. S. *
2003. Ha-ras overexpression
mediated cell apoptosis in the presence of 5-fluorouracil. Exp. Cell
Res., 288, 403-414. 44.
Chang, T. Y., Tsai, W. J., Chou, C. K.,
Chow, N. H., Leu, T. H., and Liu, H. S. * 2003. Identifying
the factors and signal pathways necessary for anchorage-independent growth of
Ha-ras oncogene-transformed NIH/3T3 cells. Life Sci., 73, 1265-1274. 45.
Huang Y. H., Lei H. Y., Liu, H. S.,
Lin Y. S., Chen S. H., Liu C. C., and Yeh T.M. 2003. Tissue plasminogen
activator induced by dengue virus infection of human endothelial cells. J Med
Virol. 70, 610-616. 46.
Hsieh, C. C., Lin, W. C., Lee, M. R., Hsu,
S. L., Liu, H. S., Kao, S. T., and Hsieh, M. T. 2003.
Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice.
Immunopharm. Immunotox. 25, 250-271. 47.
Lin C. F., Lei H. Y., Shiau A. L., Liu C.
C., Liu, H. S., Yeh T. M., Chen S. H., and Lin Y. S. 2003. Antibodies
from dengue patient sera cross-react with endothelial cells and induce
damage. J Med Virol. 69, 82-90. 48.
Lin, Y. L., Lei, H. Y., Lin, Y. S., Yeh, T.
M., Chen, S. H., and Liu, H. S. * 2002. Heparin inhibits
dengue-2 virus infection of five human liver cell lines. Antiviral Res. 56,
93-96. 49.
Lin, C. F., Lei, H. Y., Shiau, A. L., Liu,
H. S., Yeh, T. M., Chen, S. H., Liu, C. C., Chiu, S. C., and Lin, Y. S.
2002. Endothelial cell apoptosis induced by antibodies against dengue virus
nonstructural protein 1 via production of nitric oxide. J. Immunol. 169,
657-664. 50.
Cheng, H. L., Trind, B., Tzai, T. S., Liu,
H. S., Chan, S. H., Ho, C. L., Sidransky, D., and Chow, N. H. 2002.
Overexpression of c-met as a prognostic indicator for transitional cell
carcinoma of the urinary bladder. A comparison with p53 nuclear accumulation.
J. Clin. Oncol. 20, 1544-1550. 51.
Liu, C. C.,
Huang, K. J., Lin, Y. S., Yeh, T. M., Liu, H.
S.,
and Lei, H. Y., 2002. Transient CD4/CD8 ratio inversion and aberrant immune
activation during dengue virus infection. J Med Virol. 68, 241-52. 52.
Lin, Y. W., Wang, K. J., Lei, H. Y., Lin,
Y. S., Yeh, T. M., Liu, H. S., Liu, C. C., and Chen, S. H. 2002. Virus
replication and cytokine production in dengue virus-infected human B
lymphocytes. J. Virol. 76, 12242-12249. 53.
Guo, Y. L., Chang, S. C., Tsai, R. H.,
Huang, J. C., Li, C., Young, K. C., Wu, L. W., Lai, M. D., Liu, H. S. and
Huang, W. 2002. Two UVC-induced stress response pathways in HeLa cells
identified by cDNA microarray.
Environ. Mol. Mutag., 40, 122-128. 54.
Wang, C. H., Tsai, L. J., Tsao, Y. P.,
Hsieh, J. T., Chien, W. W., Liao, C. L., Wang, H. W., Liu, H. S., and
Chen, S. L., 2002. Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through
caspase-5 and mitochondria-dependent pathways. Biochem. Biophys. Res. Comm.
298, 805-814. 55.
Liu, H. S., Lee, C. H., Lee, C. F., Su, 56.
Su, W. C., Shiesh, S. C., Liu, H. S.,
Chen, C. Y., Chow, N. H., and Lin, X. Z. 2001. Expression of oncogene
products HER2/Neu and Ras and Fibrosis-Related Growth factors bFGF, TGF-��,
and PDGF in bile from biliary malignancies and inflammatory disorders. Digest. Dis. And Sci., 46, 1387-1392. 57.
Huang, Y. H., Lei, H. Y., Liu, H. S.,
Lin, Y. S., Liu, C. C., and Yeh, T.M. 2001. Dengue virus infects human
endothelial cells and induces IL-6 and IL-8 production. Am. J. Trop. Mol.
Hyg., 63, 71-75. 58.
Shen, M. R., Chou, C. Y., Hsu, K. F., Liu,
H. S., Dunham, P. B., Holtzman, E. J., and Ellory, J. C. 2001. The KCl
cotransporter isoform KCC3 can play an important role in cell growth
regulation. Proc. Natl. Acad. Sci. USA. 98, 14714-14719. 59.
Lin, C. F., Lei, H. Y., Liu, C. C., Liu,
H. S., Yeh, T. M., Wang, S. T., Yang, T. I., Sheu, F. C., Kuo, C. F., and
Lin, Y. S. 2001. Generation of IgM anti-platelet autoantibody in dengue
patients. J. Med. Virol., 63, 143-149. 60.
Chow, N. H., Chan, S. H., Tzai, T. S., Ho,
C. L., and Liu, H. S. 2001. Expression profiles of ErbB family
receptors and prognosis in primary transitional cell carcinoma of the urinary
bladder. Clin. Cancer Res., 7, 1957-1962. 61.
Huang, Y. H., Liu, C. C., Wang, S. T., Lei,
H. Y., Liu, H. S., Lin, Y. S., Wu, H. L., and Yeh, T. M. 2001.
Activation of coagulation and fibrinolysis during dengue virus infection. J.
Med. Virol., 63, 247-251. 62.
Kao, S. T., Yeh, C. C., Hsieh, C. C., Yang,
M. D., Lee, M. R., Liu, H. S., and Lin, J. G. 2001. The Chinese
medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines
by inducing apoptosis via G0/G1 arrest. Life Sci. 69, 1485–1496. 63.
Shiao, S. H., Higgs, S., Adelman, Z.,
Christensen, B. M., Liu, H. S., and Chen, C. C. 2001. Effect of
prophenoloxidase expression knockout on the melanization of microfilariae in
the mosquito Armigeres subalbatus. Insect Mol. Biol., 10,
315-321. 64.
Chen, C. C., Shieh, B., Jin, Y. T., Liau,
Y. E., Huang, C. H., Liou, J. T., Wu, L. W., Huang, W., Young, K. C., Lai, M.
D., Liu, H. S., and Li, C. 2001. Microarray profiling of gene
expression patterns in bladder tumor cells treated with genistein. J. Biomed.
Sci., 8, 214-222. 65.
Lin, Y. L., Liu, C. C., Chuang , J.I., Lei,
H. Y., Yeh, T. M., Lin, Y. S., Huang Y. H., and Liu, H. S. *
2000. Involvement of oxidative stress, NF-IL-6 and RANTES expression in
dengue-2 virus infected human liver cells. Virology 10, 114-126. 66.
Lin, Y. L., Lei, H. Y., Wen, Y. Y., Luh, T.
Y., Chou, C. K , and Liu, H. S. * 2000. Light-independent
Inactivation of Dengue-2 Virus by Carboxyfullerene C3 Isomer. Virology 275,
258-262. 67.
Lin, Y. L., Liu, C. C., Lei, H. Y., Yeh, T.
M., Lin, Y. S., Chen, M. Y., and Liu, H. S. * 2000.
Infection of five human liver cell lines by dengue-2 virus. J. Med. Virol.
60, 425-431. 68.
Chow N. H., Liu, H. S., and Chan, S.
H., 2000. The role of nm23-H 69.
Yang, B. C., Wang, Y. S., Liu, H. S.,
and Lin, S. J. 2000. Ras signaling is involved in the expression of Fas-L in
glioma. Laborat. Invest. 80, 529-537. 70.
Huang, K. J., Lin, S. Y., Chen, S. C., Liu,
H. S., Lin, Y. S., Yeh, T. M., and Lei, H. Y., 2000. Manifestation of
thrombocytopenia in dengue-2-virus-infected mice. J. Gen. Virol., 81,
2177-2182. 71.
Chow N. H., Tzai, T. S., Cheng, H. L., Liu,
H. S., Chan, S. H., and Tong, Y. C. 2000. The clinical value of
p21WAF1/CIP1 expression in superficial bladder cancer. Anticancer Res. 20,
1173-1176. 72.
Jan, M. S., Liu, H. S., and Lin, Y.
S. 1999. Bad overexpression sensitizes NIH/3T3 cells to undergo apoptosis
which involves caspase activation and ERK inactivation. Biochem. Biophys.
Res. Comm. 264, 724-729. 73.
Liu, H. S., Jan, M. S., Chou, C. K., Chen, P. H., and
Ke, N. J. 1999. Is Green Fluorescent Protein toxic to the living cells?
Biochem. Biophys. Res. Comm. 260, 712-717. 74.
Chang, T. Y., Wen, Y. Y., Su, 75.
Chang, M. Y., Won, S. J., Yang, B. C., Jan,
M. S., and Liu, H. S. * 1999. Selective activation of
Ha-rasval12 oncogene increases susceptibility of NIH/3T3 cells to TNF-��.
Experiment. Cell Res., 248, 589-598. 76.
Chow N. H., Liu, H. S., Chan, S. H.,
Cheng, H. L., and Tzai, T. S. 1999. Expression of vascular endothelial growth
factor in primary superficial bladder cancer. Anticancer Res. 19, 4593-4597. 77.
Liu, H. S., Lee, C. H., Lee, C. F., Su, 78.
Liu, M. F., Liu, H. S., Wang, C. R.,
and Lei, H. Y. 1998. Expression of CTLA-4 molecule in peripheral blood T
lymphocytes from patients with systemic lupus erythematosus. J. Clin.
Immunol. 18, 392-398. 79.
Lai, W. W., Chen, F. F., Chen, C. Y., and Liu,
H. S. 1998. Animal model of lung cancer metastasis: comparison of
efficiency of propagating human lung cancer cell lines in SCID mice with
intrabronchial, percutaneous intrathoracic, and subcutaneous routes. J. Surg.
Assoc. ROC. 31, 90-96. 80.
Liu, H. S., Chen, C. Y., Lee, C. H., and Chou, Y. I.
1998. Selective induction of oncogenic Ha-ras
induced apoptosis in NIH/3T3 cells. Brit. J. Cancer. 77, 1777-1786. 81.
Chang, M.Y., Jan, M. S., Won, S.J., and Liu,
H.S. * 1998. Ha-rasval12
oncogene increases susceptibility of NIH/3T3 cells to lovastatin. Biochem.
Biophys. Res. Comm. 248, 62-68. 82.
Chow, N. H., Liu, H. S., Chang, C.
J., Chi, Y. C., Tzai, T. S., Li, I. C., and Lin, S. N. 1998. Urinary
excretion of transforming growth factor-alpha in patients with transitional
cell carcinoma. Anticancer Res. 18, 2053-2058. 83.
Chow, N. H., Cheng, C. J., Chi, Y. C., Liu,
H. S., Tzai, T. S., and Lin, S. N. 1998. Potential value of urinary
intercellular adhesion molecule-1 determination in patients with bladder
cancer. Urology 52, 1015-1019. 84.
Su, W. C., Chow, N. H., Huang, C. H., and Liu,
H. S. * 1998. Using 2-step PCR and restriction endonuclease
digestion to detect K-ras mutation
in paraffin-embedded tissues: Is it reliable J. Clin. Laborat. Anal. 12,
168-171. 85.
Cho, W. L., Liu, H. S., Lee, C. H.,
Kuo, C. C., Chang, C. I., Liu, C. T., and Chen, C. C. 1998. Molecular
cloning, characterization and tissue expression of prophenoloxidase cDNA from
mosquito Armigeres subalbatus inoculated with Dirofilaria
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Counc. Part B: 7, 51-56. 發明專利 1.
林忠男，翁舷誌，劉校生，劉崇喜，1993‑2013，一種新奇妙腫瘤之黃環酮化物 ,日本專利，專利號碼特許久第255444號. 2.
林忠男，翁舷誌，劉校生，劉崇喜，1998-2015，台產新靈芝等相關藥用資源 合成Xanthones抗癌物質之開發研究，美國專利，專利權號數:發明第5741813號 3.
林忠男，翁舷誌，劉校生，劉崇喜，1999‑2017，台產新日本靈芝等相關藥用資源及合成Xanthones之抗癌物質之開發研究，美國專利，專利權號數:發明第 5981774號。 |
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研討會論文 |
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Liu, H. S. 2003. Development of cancer related diagnosis microarray chips in 33.
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Liu, H. S., Chow, N. H., Chiang, J. H.,
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Liu, H. S.2002. Signal transduction of
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rapidly screen and massively produce infectious dengue-2 viruses from
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Liu, H. S., Shen, H. C., and Chow, N. H.,
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Li, Y. R., and Liu, H. S. 2001.
Signal transduction of RANTES in chang liver cells after Dengue-2 virus
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Tseng, Y. S., Huang, C. Y., and Liu,
H. S. 2001. Synergistic activation of transcription factor Elk by Ras and
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Liu, H. S., Shen, H. C., and Chow, N. H.
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Tseng, Y. S., Chang, T. Y., Tzeng, C. C.,
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Lin, Y. L., Lei, H. Y., Wen Yu-Ye, and Liu,
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microbiology. 48.
Lin, Y. L., Liu, C. C., Chuang , J.I.,
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increases susceptibility of NIH/3T3 cells to TNF-��. Fifteenth annual meeting
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Lin, Y. L., Lei, H. Y., Yeh, T. M., Lin,
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A Plasmid harboring Lac repressor and Tet activator regulates two inducible genes in
mammalian cells. The 32nd annual meeting of the Chinese society of
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virus infected hepatocyte cell lines. The 32nd annual meeting of the Chinese
society of microbiology. 56.
Chou, C. K., and Liu, H. S. 1998.
Study on apoptosis and colony formation of a NIH/3T3 derivative 7-4
containing an inducible Ha-ras
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to TNF-��. Sixth symposium on recent advances in cellular and molecular
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Pathogenic study on five hepatoma cell lines after dengue-2 virus
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Construction of infectious full-length dengue-2 virus cDNA.97th General
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Demonstration of Tet and Lac double inducible gene regulation in many cell
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S. 1997. Effect of Ha-ras
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Study on Ha-ras induced apoptosis
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molecular biology, 88, P40. 65.
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Construction infectious full-length dengue virus type 2 cDNA. The 30th annual
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synthesis in mosquito AP-61 and mammalian BHK-21 cells. The 29th Annual
meeting of the Chinese Society of Microbiology, National Taiwan University,
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94rd ASM general meeting,. 73.
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The effect of Ha-ras oncogene on colony formation of transformed
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Liu, H. S. 1993. PCR 在醫學診斷及刑事科學之應“DNA聚合鋛連鎖反應之應” 研習會, National Chung Sun
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NIH/3T3 fibroblast cell line. First Symposium on Recent Advances in Cellular
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Liu, H. S., Chang, T. Y. and Chen, C.C.
1993. Detection of dengue-2 virus by northern blotting and in situ
hybridization using a radioactive and non-radioactive exchangeable labeling
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Lin, Y. L., Chen, C. C., and Liu, H.
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Gung college of Medicine, Tao-Yuan, Taiwan, R. O. C. , 68. 78.
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harboring NLS at different locations. The 27th Annual meeting of the Chinese
Society of Microbiology, Chang Gung college of Medicine, Tao-Yuan, Taiwan, R.
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Liu, H. S. 1992. SV40 early promoter
drives gene expression under the regulation of bacterial regulatory elements.
Workshop on the establishment of mammalian cell lines by transformation with
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Liu, H. S., Chang, T. Y. and Chen, C.C.
1992. Development of non-radioactive probes for the detection of dengue-2
virus. Arboviruses Conference, 81.
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Stambrook, P. J. 1991. Transformation of NIH 3T3 cells can be controlled by
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|
榮譽與獎勵 |
1991 1993 國科會甲種獎助 1994 國科會甲種獎助 1995 國科會甲種獎助 1996 國科會甲種獎助 1999 國科會甲種獎助 2000 國科會甲種獎助 2001 國科會甲種獎助 1994
指導醫技三陳炳宏參加醫學院暑期研究論文比賽榮獲第一名 1995
指導醫技四陳炳宏參加第六屆全校論文比賽榮獲特優獎 1995
獲頒校長熱心教育獎 1995
指導醫學三周言穎參加醫學院暑期研究論文比賽獲第一名 1996
指導醫學四周言穎參加第七屆全校論文比賽獲特優獎 1996
獲頒校長熱心教育獎 1997
指導醫技三柯妮妗參加醫學院暑期研究論文比賽獲第三名 2002 指導微免碩二李英瑞參加第三十六屆中華民國微生物學會海報論文比賽獲病毒組第二名 2003 指導博三葉宣亨參加92年基醫所研究日海報論文比賽優勝 2004 指導博二李英瑞參加第三十八屆中華民國微生物學會海報論文比賽獲病毒組第二名 2004
指導生科三陳偉愷參加國科會暑期研究論文比賽獲優等獎 2005
指導博三李英瑞參加第二十屆中華民國生物醫學聯合學術年會優良看板論文壁報獎 2006 第十四屆細胞及分子生物新知研討會研究生論文競賽優勝 2006
九十四年度基礎醫學博士班學生研究口頭發表競賽優勝 2007 第十五屆細胞及分子生物新知研討會研究生論文競賽優勝 |