99學年度高等分子生物學 （Molecular Biology Fall Semester 2010）
時 間：星期二、AM 9:10-12:00
地 點：第四講堂 生化所PBL教室：601教室
協調人：張文粲教授 Tel: 5533 E-mail: wtchang@mail.ncku.edu.tw
助 教： (5532)
將生物現象的種種機能循分子層次進行研究之分子生物學是生物學結合物理學、化學而發展出的新科學領域，隨著分子生物學之進展所開發出之基因工程技術，是探討生命科學奧妙，造褔人類重要之科學技術之一。本課程以真核細胞分子生物為主，並補充介紹目前基因工程所採用之重要技術的理論、方法實驗與實例等。
此課程為醫學院生化，微免，分醫，醫技碩士班及基醫，臨醫博士班共同課程，前十堂課以講堂授課。將基本的Genome, replication, transcription, translation, 及bioinformatics傳授重要之知識。其後六堂課，以小教室討論進行，其方式有兩種，一為由教師提出一個研究問題，由學生查尋research articles來加以回答，並共同討論；另一種方式則由教師提供研究論文，由學生分組討論。小教室討論時，由張明熙，張敏政，吳昭良，鄭宏祺，張文粲共同負責生化所碩士班學生。
Course Goals:
1) to assist graduate students in understanding the history and future challenge of molecular biology from discovery of DNA to genome sciences, and
2) to better students in gaining insight on how to utilize modern molecular biology tools and computational approaches in experimental design and problem shooting.
Course Format:
1) Lectures for 3 hr by teachers, or 2-hr lectures by teachers followed by student presentation (if assigned) or an impromptu examination for 1 hr or less. Interactive teaching is encouraged.
2) Each lecture note will be posted online (Department of Biochemistry and Molecular Biology website) or distributed after the class as hard copies (if agreed by the teacher).
3) Assigned reading(s) will be posted online (Department of Biochemistry and Molecular Biology website) one or two weeks before each class.
4) Homework will be given after each class.
Course Materials:
GENE IX, 2008 and assigned readings.
Grading Criteria:
Homework and final examination; 前11次上課考試原始成績將分送給各所負責開高等分子生物學之老師，於學期末再加入各所上課教學評分，由各所自行計算調整後送往教務處。
課程時間表
|
Topic |
Lecturer |
|
|
9/14/2010 |
Introduction: History & Molecular Biology of Diseases |
張文粲 |
|
9/21/2010 |
Genome, Chromosomes and Nucleosomes |
陳昌熙 |
|
9/28/2010 |
DNA Replication (Eucaryotic and Procaryotic) |
王憲威 |
|
10/5/2010 |
DNA Recombination & Repair (Eucaryotic & Procaryotic) |
黃溫雅 |
|
10/12/2010 |
Procaryotic Transcription |
鄧景浩 |
|
10/19/2010 |
Procaryotic Translation |
鄧景浩 |
|
10/26/2010 |
Eucaryotic Transcription |
|
|
11/2/2010 |
Eucaryotic Translation and Protein Degradation |
凌 斌 |
|
11/9/2010 |
Protein Structure and Function |
王淑鶯 |
|
11/16/2010 |
Molecular Biology of Carbohydrate |
鄭宏祺 |
|
11/23/2010 |
Molecular Biology of Stem Cells |
謝清河 |
|
11/30/2010 |
Final Examination |
張文粲 |
|
12/7/2010 |
生化所PBL |
張明熙 |
|
12/14/2010 |
生化所PBL |
張敏政 |
|
12/21/2010 |
生化所PBL |
吳昭良 |
|
12/28/2010 |
生化所PBL |
鄭宏祺 |
|
1/4/2011 |
生化所PBL |
張文粲 |
12/7/2010、12/14/2010、12/21/2010、12/28/2010、1/4/2011為PBL課程，請各所自行安排課程及準備教室。
· 生化所碩士班張文粲老師負責。
· 分醫所碩士班由張南山、蔣輯武老師負責。
· 醫技所碩士班學生由楊孔嘉、黃溫雅老師負責。
· 微免所碩士班學生由微免所楊倍昌老師負責。
· 基醫所、臨醫所博士班學生分別由賴明德、呂佩融老師負責。
· 其他外系所學生，視其選修系所科目，由該選修系所負責。各系所老師自行斟酌是否接受選修。
· Coordination 99年由生化所負責。
Course Rule for Students
Skipping classes, or being late for attending classes, is strongly discouraged. If you are caught for 3 times from skipping classes, you will be dismissed or flunked.
99分子生物學 分醫所及醫技所 PBL共同課程
地 點：_303D 教室/分醫所 (3F)會議室
星期二、AM 9:10-12:00
協調人：分醫所: 張南山 (5268) 蔣輯武 (3637) 醫技所: 黃溫雅 (5766) 楊孔嘉 (5787)
|
Date |
Topic |
Instructor |
|
12/7 |
Fluorescence-based methods in the study of protein-protein interactions in living cells group list & assignment |
蔣輯武
|
|
12/14 |
Single molecule–sensitive probes for imaging RNA in live cells supplement & assignment |
楊孔嘉 王憲威 |
|
12/21 |
Gene expression during embryogenesis supplement |
傅子芳 |
|
|
Glycan microarray and cancer analysis |
張權發 |
|
12/28 |
Functional genomics supplement Functional genomics supplement |
張玲 謝逸璇 |
|
1/04/2011 |
Gene Defects and Cancer supplement |
吳梨華 張南山 |
|
1/12/2011 |
Final oral and/or written make-up exams for failing students (if needed) |
張南山 蔣輯武 黃溫雅 楊孔嘉 |
Note:
1) Key agenda of PBL class: to train students in problem solving in the areas of technological innovations and molecular mechanisms underlying diseases.
2) Classes will be run in a combined format of both IMM and MLSB students. The students will be grouped for discussing assigned questions and papers.
3) Pre-class reading, assigned questions and grouping of students will be posted on the MLSB department homepage. Please send the teaching materials and assignment to 楊孔嘉 (ext. 5787, email: t7908077@mail.ncku.edu.tw) or程麗菁 (ext. 5783, email: clcberyl@mail.ncku.edu.tw).
4) Grading PBL performance includes (a) in-class presentation and discussion (b) take-home exam
5) Final scoring policy: 前11次上課考試原始成績佔60%、 PBL: 每次 8% (8% x 5 = 40%)