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謝達斌    Dar-Bin Shieh

          

職稱：

教授兼主治醫師兼成大口腔醫學科科主任暨研究所所長

電話：

(Office) +886-6-235-3535 ext. 5410
(Lab) +886-6-235-3535 ext. 5376, 5377

傳真：

+886-6-276-6626

EMail：

dshieh@mail.ncku.edu.tw

實驗室：

Laboratory of Translational Nanomedicine

學歷：

美國哈佛大學牙醫學院分子生物學醫學科學博士(DMSc., 1997)
美國哈佛大學牙醫學院口腔病理學專業證書(1997)
國立陽明大學牙醫學系學士(1988)

經歷：

國立成功大學口腔醫學科科主任暨研究所所長(2009.08-)
國立成功大學口腔醫學科暨口腔醫學研究所教授(2008.08-)
國立成功大學研究發展處企劃組長(2007.02-2009.08)
成大醫院口腔醫學部主治醫師兼口腔診斷及一般牙科主任(2000.08-)
國立成功大學口腔醫學科暨口腔醫學研究所副教授(2005.08-2008.07)
國立成功大學微奈米科技研究中心研究教育組長(2005.10-2007.01)
國立成功大學牙科學科暨口腔醫學研究所助理教授(1999.02-2005.07)
國立成功大學分子醫學研究所合聘助理教授(1999.08-2004.07)
美國哈佛大學醫學院實驗醫學部研究學者(1997.07-1999.01)
美國哈佛大學牙醫學院研究員(1991.09-1997.06)

　

 　

　

 　

A.專長


口腔病理學 　　
分子生物學 　　
腫瘤學 　　
牙科學 　　
奈米生物醫學
 

B. 教授課程


口腔生物學 　　
奈米生物醫學 　　
儀器分析
 		 　

C. 研究興趣
奈米科技於臨床與基礎醫學之應用 　　
分子腫瘤學 　　
粒線體醫學 　　
細胞生物物理與行為
 　

　

1. Best Basic Science Award in 10th International Congress on Oral Cancer, 2005 Apr. (Sponsored by WHO, ICOOC, HATMC, HCS)
2. 生技製藥國家型科技計畫審查委員(2010~)
3. 2009 Taiwan Nano 國科會展覽館生醫材料領域召集人
4. 奈米國家型科技計畫第二期規劃：前瞻研究－奈米生醫領域規劃委員(2007~2008)
5. 國立成功大學95~98學年度『研究及產學成果優良』最高獎勵（A級）
6.  國科會生物處專題研究計劃複審委員(2006~2009)
7. 國立成功大學95學年度教學優良教師
8. Who’s Who in the World 2007, Marquis Who’s Who, USA
9. Member of Advisory Board, 2007 International Conference on Bionano Sciences, Taiwan (2007 ICONBS, Taiwan)
10.The Co-Chair of Session Topic ST 10: Nano-bio Fusion, Nano Biology, Nano-Bio-Medical Science. The Technical Program 
     Committee of the IEEE Nano 2008 conference, Arlington, TX, August 18-21, 2008.
11. 財團法人成杏文教基金會優秀論文獎2006 ~ 2008
12. Member of IEEE Technical Committee on Nano-Biomedicine (Since 2006)
13. 臺灣粒線體醫學會理事 (Since 2006)
14. Fellow, The International Academy of Oral Oncology (Since 2005)
15. Editorial Board, Journal of Taiwan Nanotechnology Industry Development Association (Since 2005)
16. 2002~2012 國科會計劃研究主持人獎
17. 九十二年度國科會大專學生研究創作之論文指導獎。
18. Schering Scholar 1985 from the American Bureau for Medical Advancement in China (ABMAC)
19. Invited Reviewer for Journals： Biomaterials, Materials Chemistry and Physics, Bioorganic & Medicinal Chemistry Letters, Colloids
      and Surfaces B：Biointerfaces, Journal of Biomedical Science, Optical Materials, Journal of Clinical Pathology, Journal of Dental
      Research, Microscopy and Microanalysis,Optics Letters, Chemosphere, etc.
　

      1.  Tsai TL, Shieh DB*, Su WC, Yeh CS, Tzeng Y, Li KTJ, Chuang KS, Hwu JR. The Down Regulation of Target Genes by Photon             Activated DNA Nanoscissors. Revising by Biomaterials, 2010 Apr. (SCI) (Impact Factor: 6.646; ranking: 2/51, 1/19).

      2.  Lai YH, Yang JT, Shieh DB*. A Microchip Fabricated with a Vapor-diffusion Self-assembled- monolayer Method to Transport               Droplets across Superhydrophobic to Hydrophilic Surfaces. Lab on a Chip, 10:499-504, 2010. (SCI) (Impact Factor: 6.478;

            ranking: 4/65)

      3.  Shieh DB, Li RY, Liao JM, Chen GD, Liou YM. Effects of Genistein on ß-catenin Signaling and Subcellular Distribution of Actin-     

           Binding Proteins in Human Umbilical CD105-Positive Stromal Cells. Journal of Cellular Physiology, 223(2), 423-434, 2010        

           May. (SCI) (Impact Factor: 4.313; ranking: 8/74).

      4.  Chang CM, Chiou LF, Lin CC, Shieh DB*, Lee GB. Three-Dimensional Microfluidic Chip for Extraction of Mitochondrial DNA.  

           Microfluidics and Nanofluidics, DOI: 10.1007/s10404-010- 0565-8. (SCI) (Impact Factor: 3.314; ranking: 2/26, 4/56).

      5.  Sun HY, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC. Comparative proteomic profiling of plasma very-

           low-density and low-density lipoproteins. Clinica Chimica Acta, 441(5-6), 331-344, 2010 Mar. (SCI). (Impact Factor: 2.96;

           ranking: 5/27)

      6.  Chang HJ, Wu CM, Chang YC, Fanchiang JC, Shieh DB*, Wong TY. Collagen enhances biocompatibility and strength of

           glassionomer. Journal of Dental Research, 88(5):449-454, 2009 May. (SCI) (Impact Factor: 3.142; ranking: 3/55)

      7.  Hsieh CC, Huang SB, Wu PC, Shieh DB*, Lee GB. A Microfluidic Cell Culture Platform for Real-time Cellular Imaging.

           Biomedical Microdevices, 11(4):903-913, 2009 Aug. (SCI) (Impact Factor: 2.924; ranking: 7/52)

      8.  Jeng YR, Lin TT, Shieh DB*. Nanotribological Characterization of Tooth Enamel Rod Affected by Surface Treatment. Journal of

           Biomechanics, 42(14):2249-2254, 2009 Oct. (SCI) (Impact Factor: 2.784; ranking: 9/51)

      9.  Wu CM, Wu PC, Wang YH, Li TJ, Yang LX, Wu YN, Yang HY, Shieh DB*. Synthesis of Polynucleotide Modified Gold

           Nanoparticles as a High Potent Anti-cancer Drug Carrier. Journal of the Chinese Chemical Society, 56(4):703-708, 2009 Aug. 

           (SCI) (Impact Factor: 0.770; ranking: 82/127)

      10.  Tsai MC, Tsai TL, Shieh DB, Chiu HT, Lee CY. Detecting HER2 on Cancer Cells by TiO2 Spheres Mie Scattering. Analytical

             Chemistry, 81(18):7590-7596, 2009 Sep. (SCI) (Impact Factor: 5.712; ranking: 1/70)

      11.  Hwu JR, Lin YS, Josephrajan T, Hsu MH, Cheng FY, Yeh CS, Su WC, Shieh DB. Targeted Paclitaxel by Conjugation to Iron

             Oxide and Gold Nanoparticles. Journal of the American Chemical Society, 131(1):66-68, 2009 Jan. (SCI) (Impact Factor:

             8.091; rank: 7/125)

      12.  Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong HC, Chiang WF, Wong TY, Shieh DB, Shiau AL, Jin YT, Chen YL.

             Galectin-1-Mediated Tumor Invasion and Metastasis, Up-Regulated Matrix Metalloproteinase Expression, and Reorganized Actin

             Cytoskeletons. Molecular Cancer Research, 7(3): 311-318, 2009 Mar. (SCI) (Impact Factor: 4.533; rank: 35/143)

      13.  Wu PC, Su CH, Cheng FY, Weng JC, Tsai TL,Yeh CS, Chen JH, Hwu JR, Tzeng Y, Su WC, Shieh DB*. Modularly Assembled

             Magnetite Nanoparticles Enhance in vivo Targeting for Magnetic Resonance Cancer Imaging. Bioconjugate Chemistry, 19 (10):

             1972-1979, 2008 Oct. (SCI) (Impact Factor: 4.584; rank: 5/55)

      14.  Jeng YR, Lin TT, Wong TY, Chang HJ, Shieh DB*. Nano-mechanical properties of fluoride treated enamel surface. Journal of

             Dental Research, 87(4):381-385, 2008 Apr. (SCI) (Impact Factor: 3.142; ranking: 3/55)

      15.  Li PC, Wang CRC, Shieh DB, Wei CW, Liao CK, Poe C, Jhan S, Ding AA, Wu YN. In vivo photoacoustic molecular imaging with  

             simultaneous multiple selective targeting using antibody-conjugated gold nanorods. Optics Express, 16(23): 18605-18615, 2008

             Nov. (SCI) (Impact Factor: 3.88; ranking: 3/64)

      16.  Yang CY, Wei CW, Lin YP, Tseng HC, Wu YN, Chen CC, Shieh DB*, Li PC. Applications of Carbohydrate-Gold Nanoparticles

              for Volumetric Flow Measurements Using an Opto-Acoustic Technique. Journal of the Chinese Chemical Society, 55(1):103-

              108,2008 Feb. (SCI) (Impact Factor: 0.770; ranking: 82/127)

      17.  Chang FY, Wang SPH, Su CH, Tsai TL, Wu PC, Shieh DB, Chen JH, Hsieh PCH, Yeh CS. Stabilizer-free poly(lactide-co-

             glycolide) nanoparticles for multimodel biomedical probes. Biomaterials, 29(13): 2104-2112, 2008 May. (SCI) (Impact Factor:

             6.646; ranking: 2/51, 1/19)

      18.  Ju CP, Chen YH, Ho WF, Ho SC, Chen WC, Shieh DB, Lin JHC. Effect of heat treatment on structure and properties of dispersed-

             type dental amalgam. Journal of Materials Science-Materials in Medicine, 19(1):83-93, 2008 Jan. (SCI) (Impact Factor:

             1.508; ranking: 12/19)

      19.  Hu KW, Huang CC, Hwu JR, Su WC, Shieh DB, Yeh CS. A new photothermal therapeutic agent: core-free nanostructured

             AuxAg1-x Dendrites. Chemistry-A European Journal, 14(10): 2956-2964, 2008. (SCI) (Impact Factor: 5.454; ranking: 12/127)

      20.  Huang CC, Lo YW, Kuo WS, Hwu JR, Su WC, Shieh DB, Yeh CS. Facile Preparation of Self-assembled Hydrogel-like

             GdPO4·H2O Nanorods. Langmuir, 24: 8309-8313, 2008. (SCI) (Impact Factor: 4.097; ranking: 23/113)

      21.  Sheu YL, Wei CW, Wang CRC, Shieh DB, Li PC. Nanoparticle Design for In Vivo Molecular Imaging with Photoacoustics.

             Submitted.

      22.  Chen YL, Hsieh WY, Yeh CS, Wong TY, Zhang JB, Shieh DB*. Single-domain-antibody Self-assembled Nanoparticles for

             Molecular Imaging of Oral Cancers. Submitted.

      23.  Jeng YR, Lin TT, Hsu HM, Chang HJ, Shieh DB*. Human Enamel Rod Presents Anisotropic Nanotribological Properties. Submitted.

24.        Wu YN, Braet F, Shieh DB*, Shi XY, Lian CC, Yeh CS, Ratinac K, Thordarson P, Chen DH. Iron-core-gold-shell nanoparticles  

             have specific anti-proliferation properties in oral squamous cell carcinoma. Submitted.

      25.  Li PC, Wang CRC, Shieh DB, Wei CW, Liao CK, Poe C, Jhan S, Wu PC, Yang ZS.Combining photoacoustic molecular imaging,

             targeted thermal therapy, and noninvasive temperature monitoring with gold nanorods. Submitted.

      26.  Chou SW, Shiau YH, Wu PC, Yang YS, Shieh DB*, Chen CC. Facile Synthesis of FePt Nanoparticles of Different Sizes for

             CT/MRI Dual Modal Molecular Targeting Imaging Contrast Agents. Submitted.

      27.  Tsai MR, Chen SY, Shieh DB, Lou PJ, Sun CK. In vivo optical virtual biopsy of human oral cavity with harmonic generation  

             microscopy. Submitted.

      28.  Hsu MH, Fang WF, Lai YH, Yang JT, Tsai TL, Shieh DB*. Mobile Conjugation of Gold Nanoparticles Decorated with

             Oligonucleotide in Microchannel Devices. (in preparation)

      29.  Hsu MH, Shieh DB*, Yang JT, Lu HJ. DNA hybridization and mutation detection by an on-chip fluorescent resonance energy transfer

             assay. (in preparation)

      30.  Hsu MH, Shieh DB*, Yang JT, Lu HJ. Dense gold nanoparticle coated on Si-based substrate and its application. (in preparation)

      31.  Fang WF, Hsu MH, Lai YH, Yang JT, Tsai TL, and Shieh DB. Mobile Conjugation of Decorated Gold Nanoparticles with

             Oligonucleotide in Microchannel Devices. (in preparation)

      32.  Chiou LF, Huang PY, Lee YC, and Shieh DB*. Investigation of Oral Carcinogenesis Biomarker by FT-IR Microspectroscopy. (in

             preparation)

      33.  Wu PC, Yang ZS, Ding AA, Chen ZM, Wang CRC, Li PC, Shieh DB*. Gold Nano Rods Targeting Her-2 Enabled Cancer

             Theranostics through Combined Photoacoustic Molecular Imaging and Laser Induced hyperthermia. (in preparation)

      34.  Wu PC, Yang ZS, Wang CRC, Li PC, Shieh DB*. Evaluation of Gold nanoparticle biodistribution in vivo with respect to size, shape

              and surface modifications. (in preparation)

      35.  Liu MH, Ding AA, Shieh DB, Wang CRC. Laesr Treatment in Temperature Rises and Malfunction of Membrane Antigen for In-vitro

             Cancer Cells NIR Laser-induced Thermotherapy. (in preparation)

      36.  Li TJ, Yang LS, Shieh DB. Cyclic Progression of Stem Cell Marker in Oral Cancer Cell. (in preparation)

      37.  Wu PC, Wang WS, Huang YT, Shen HS, Lo YW, Tsai TL, Shieh DB*, Yeh CS. Porous Iron Oxide-Based Nanorods Developed as

             Delivery Nanocapsules. Chemistry-A European Journal, 13(14): 3878-3885, 2007 May. (SCI) (Impact Factor: 5.454; ranking:

             12/127)

      38.  Shieh DB, Chen CC, Shih TS, Tai HM, Wei YH, Chang HY. Mitochondrial DNA alterations in blood of the humans exposed to N,

             N-Dimethylformamide. Chemico-Biological Interactions, 165(3): 211-219, 2007 Feb. (SCI) (Impact Factor: 3.077; ranking: 18/75)

      39.  Tai SP, Wu YN, Shieh DB, Chen LJ, Lin KJ, Yu CH, Chu SW, Chang CH, Shi XY, Wen YC, Lin KH, Liu TM, Sun CK. Molecular

             Imaging of Cancer Cells Using Plasmon-Resonant-Enhanced Third-Harmonic-Generation in Silver Nanoparticles. Advanced

             Materials, 19(24): 4520-4523, 2007 Dec. (SCI) (Impact Factor: 8.191; rank: 4/113)

      40.  Lin MC, Chu CJ, Tsai LC, Lin HY, Wu CS, Wu YP, Wu YN, Shieh DB, Su YW, Chen CD. Control and detection of organosilane

             polarization on nanowire field-effect-transistors. Nano Letters, 7(12): 3656- 3661, 2007 Dec. (SCI) (Impact Factor: 10.371; ranking:

             6/191, 2/50)

      41.  Su CH, Sheu HS, Lin CY, Huang CC, Lo YW, Pu YC, Weng JC, Shieh DB, Chen JH, Yeh CS. Nanoshell Magnetic Resonance

             Imaging Contrast Agents. Journal of the American Chemical Society, 129(7): 2139-2146, 2007 Feb. (SCI) (Impact Factor: 8.091;

             rank: 7/125)

      42.  Hsu MH, Josephrajan T, Yeh CS, Shieh DB, Su WC, Hwu JR. Novel arylhydrazone-conjugated gold nanoparticles with DNA-

             Cleaving ability: The first DNA-Nicking nanomaterial. Bioconjugate Chemistry, 18 (6): 1709-1712, 2007 Nov-Dec. (SCI) (Impact

             Factor: 4.584; rank: 5/55)

      43.  Su WP, Tu IH, Hu SW, Yeh HH, Shieh DB, Chen TY, Su WC. HER-2/neu raises SHP-2, stops IFN-gamma anti-proliferation in

             bladder cancer. Biochemical and Biophysical Research Communications, 356 (1): 181-186, 2007 Apr. (SCI) (Impact Factor:2.648;

             ranking: 28/70)

      44.  Li PC, Wei CW, Liao CK, Chen CD, Pao KC, Wang CRC, Wu YN, Shieh DB. Photoacoustic imaging of multiple targets using gold

             nanorods. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, 54 (8): 1642-1647, 2007 Aug. (SCI) (Impact

             Factor:2.16; ranking: 5/26)

      45.  Shieh DB*, Yeh CS, Chang WC, Tzeng Y. The integration of biomedical nanotechnology education program in Taiwan. Journal of

             Materials Education (Proceedings of the Symposium and Forum Education in Materials Science, Technology and Engineering), 29(1-

             2):107-116, 2007 July.

      46.  Tzeng Y, Shieh DB. Nanoscience and nanotechnology human resource development for higher education in Taiwan. Journal of

             Materials Education(Proceedings of the Symposium and Forum Education in Materials Science, Technology and Engineering), 29(1-2)

             :141-148, 2007 July.

      47.  Liu CP, Wu JJ, Chen DH, Huang JCA, Chung CK, Lee YC, Huang JL, Sahu DR, Shieh DB, Tzeng Y. A multidisciplinary

             introductory nanotechnology course with hands-on experiments. Journal of Materials Education, 29(3-4):215-234, 2007 Dec.

      48.  Shieh DB*, Su CH, Chang FY, Wu YN, Su WC, Hwu JR, Chen JH, Yeh CS. Aqueous nickel-

             nitrilotriacetate modified Fe3O4–NH3+ nanoparticles for protein purification and cell targeting. Nanotechnology, 17(16): 4174-4182,

             2006 Aug. (SCI) (Impact Factor: 3.446; ranking: 3/68)

      49.  Shieh DB, Chen IW, Shiao CY, Wei CY, Chung CH, Chang HJ, Jin YT, Wong TY. Tissue expression of gelsolin in oral  

             carcinogenesis progression and its clinicopathological implications. Oral Oncology, 42(6):599-606, 2006 Jul. (SCI) (Impact Factor:

             2.928; ranking: 5/55)

      50.  Hsiao MT, Chen SF, Shieh DB*, Yeh CS. One-Pot Synthesis of Hollow Au3Cu1 Spherical-Like and Biomineral Botallackite Cu2

                (OH)3Cl Flower- Like Architectures Exhibiting Anti-microbial Activity. Journal of Physical Chemistry B, 110(1): 205-210, 2006 Jan.

            (SCI) (IF: 4.086; ranking: 19/110)

      51.  Yang WH, Lee CF, Tang HY, Shieh DB, Yeh CS. Iron Oxide Nanopropellers Prepared by a Low-Temperature Solution Approach.

             Journal of Physical Chemistry B, 110(29): 14087-14091, 2006 Jul.(SCI) (IF: 4.086; ranking: 19/110)

      52.  Tai SP, Lee WJ, Shieh DB, Wu PC, Huang HY, Yu CH, Sun CK. In vivo optical biopsy of hamster oral cavity with epi-third-

             harmonic-generation microscopy, Optics Express, 14(13): 6178-6187, 2006 Jun. (SCI) (Impact Factor: 3.88; ranking: 3/64)

      53.  Huang CC, Hwa JR, Su WC, Shieh DB, Tzeng YH, Yeh CS. Surfactant- Assisted Hollowing of Cu Nanopaticles Incorporating with

             Halide-Induced Corrosion Oxidation. Chemistry-A European Journal, 12(14): 3805-3810, 2006 May. (SCI) (Impact Factor: 5.454;

             ranking: 12/127)

      54.  Lu J, Yang S, Ng KM, Su CH, Yeh CS, Wu YN, Shieh DB. Solid-state synthesis of monocrystalline iron oxide nanoparticles

             (MIONs) ferrofluid for application as MRI contrast agent. Nanotechnology, 17(23):5812-5820, 2006 Dec. 18 (28): Art. No.

             289001, 2007 Jul. (SCI) (Impact Factor: 3.446; ranking: 3/68)

      55.  Pu YC, Hwa JR, Su WC, Shieh DB, Tzeng YH, Yeh CS. Water Dissolvable Sodium Sulfate Nanowires as a Versatile Template for

             the Synthesis of Polyelectrolyte and Metal-based Nanotubes. Journal of the American Chemical Society, 128(35): 11601-11611,

             2006 Sep. (SCI) (Impact Factor: 8.091; rank: 7/125)

      56.  Shieh DB, Yang SR, Shi XY, Wu YN, Wu SN. Properties of BKca Channels in Oral Keratinocytes. Journal of Dental Research, 84

            (5):468-473, 2005 May. (SCI) (Impact Factor: 3.142; ranking: 3/55)

      57.  Shieh DB*, Cheng FY, Su CH, Yeh CS, Wu MT, Tsai CY, Wu CL, Chen DH, Chou CH. Aqueous Dispersions of Magnetite

             Nanoparticles with NH3+-surfaces for magnetic manipulations of biomocules and MRI contrast agents. Biomaterials, 26(34): 7183-

             7191, 2005 Dec. (SCI) (Impact Factor: 6.646; ranking: 2/51, 1/19)

      58.  Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB*. Characterization of a newly synthesized Fe3O4

             nanoparticle aqueous dispersions and its biomedical applications. Biomaterials, 26: 729-738, 2005 Mar. (SCI) (Impact Factor: 6.646;

             ranking: 2/51, 1/19)

      59.  Liu JK, Chung CH, Chang CY, Shieh DB. Bond strength and debonding characteristics of a new ceramic bracket. American Journal

             of Orthodontics & Dentofacial Orthopedics, 128(6): 761-765, 2005 Dec.(SCI) (Impact Factor:1.126; ranking: 35/51)

      60.  Tai SP, Tsai TH, Lee WJ, Shieh DB, Liao YH, Huang HY, Zhang KYJ, Liu HL, Sun CK, Optical biopsy of fixed human skin with

             backward-collected optical harmonics signals, Optics Express, 13: 8231-8242, 2005 Oct. (SCI) (Impact Factor: 3.88; ranking: 3/64)

      61.  Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, Wu CL. Thrombospondin 1 as an effective gene therapeutic strategy in

             collagen-induced arthritis. Arthritis and Rheumatism, 52(1): 339- 344, 2005 Jan. (SCI) (Impact Factor: 7.677; ranking: 1/21)

      62.  Chang YC, Shieh DB*, Chang CH, Chen DH. Conjugation of Monodisperse Chitosan-bound Magnetic Nano-carrier with Epirubicin  

             for Targeted Cancer Therapy. Journal of Biomedical Nanotechnology, 1(2): 196-201, 2005. (SCI) (Impact Factor: 0.989)

      63.  Shieh DB*, Chou WB, Wei YH, Wong TY, Jin YT. Mitochondrial DNA 4977 bp deletion in paired oral cancer and precancerous

             lesions revealed by lasermicrodissection and real-time quantitative PCR. Annals of the New York Academy of Sciences

             (Mitochondrial Pathogenesis: from Genes and Apoptosis to Aging and Disease), 1011: 154-167, 2004. (SCI) (Impact Factor: 1.731;  

             ranking:9/50)

      64.  Tsai CY, Shiau AL, Cheng PC, Shieh DB, Chen DH, Chou CH, Yeh CS, Wu CL. A biological strategy for fabrication of Au:EGFP

             nanoparticle conjugates retaining bioactivity. Nano Letters, 4(7): 1209-1212, 2004. (SCI) (Impact Factor: 10.371; ranking: 6/191,

             2/50)

      65.  Jen CP, Chen YH, Fan CS, Yeh CS, Lin YC, Shieh DB, Wu CL, Chen DH, Chou CH. A Nonviral Transfection Approach in Vitro:

             The Design of a Gold Nanoparticle Vector Joint with Microelectro-

             mechanical Systems. Langmuir, 20(4): 1369-1374, 2004. (SCI)(Impact Factor: 4.097; ranking: 23/113)

      66.  Chuang SF, Jin YT, Liu JK, Chang CH, Shieh DB.Influence of flowable composite lining thickness on class II composite restorations.

             Operative Dentistry, 29(3): 301-308, 2004. (SCI)

      67.  Chung CH, Wong TY, Shieh TY, Shieh DB, Chao SH. Nevoid Basal Cell Carcinoma Syndrome- Clinical Manifestations and

             Mutation Analysis of a Taiwanese Family. Journal of the Formosan Medical Association, 102: 793-797, 2004. (SCI)

      68.  Chung CH, Yang YH, Chang TT, Shieh DB, Liu SY, Shieh TY. Relationship of oral lichen planus to Hepatitis C virus in Southern

             Taiwan. The Kaohsiung Journal of Medical Sciences, 20(4): 151-159, 2003.

      69.  Chang KC, Su IJ, Tsai ST, Shieh DB, Jin YT. Pathological features of betel quid-related oral epithelial lesions in Taiwan with special

             emphasis on the tumor progression and human papillomavirus association. Oncology-Basel, 63: 362-369, 2002. (SCI)

      70.  Chen YJ, Jin YT, Shieh DB, Tsai ST, Wu LW. Molecular characterization of angiogenic properties in oral squamous cell carcinoma

             cells. Oral Oncology, 38(7): 699-705, 2002. (SCI)

      71.  Liu JK, Chang LT, Chuang SF, Shieh DB. Shear bond strengths of plastic brackets with a mechanical base. Angle Orthodontist, 72(2):

             141-45, 2002. (SCI)

      72.  Marks PW, Bandura JL, Shieh DB, Foernzler D, Beier DR, Kwiatkowski DJ. The spontaneous coat color mutant white nose (wn)

             maps to murine chromosome 15. Mammalian Genome, 10(7): 750-2, 1999.(SCI)

      73.  Shieh DB, Godleski J, Herndon JE II, Azuma T, Mercer H, Sugarbaker DJ, Kwiatkowski DJ. Cell motility as a prognostic factor in

             Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. Cancer, 85(1): 47-57, 1999. (SCI)

      74.  Kwiatkowski DJ, Harpole DH Jr., Godleski J, Herndon JE II, Shieh DB, Richards W, Blanco R, Xu HJ, Strauss GM, Sugarbaker DJ.

             Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications. Journal of Clinical Oncology,   

             16(7): 2468-77, 1998. (SCI)

      75.  Young ST, Yip SW, Cheng HC, Shieh DB. 3-Dimensional Surface Digitizer for Facial Contour Capture. IEEE Engineering in

             Medicine and Biology Magazine, 13 (1): 125-128, 1994. (SCI)

     

Proceedings Paper:

      1.   Jeng YR, Mao CP, Lin TT, Shieh DB. Contact mechanics study in biotribology: A tissue engineering example. Proceedings of  

            the ASME/STLE International Joint Tribology Conference, PTS A AND B, 2008, 541-543.

      2.   Shieh DB*, Yeh CS, Chang WC, Tzeng Y. The integration of biomedical nanotechnology education program in Taiwan. Proceedings  

            of the Symposium and Forum Education in Materials Science, Technology and Engineering, 2007, 107-116.

      3.   Tzeng Y, Shieh DB. Nanoscience and nanotechnology human resource development for higher education in Taiwan. Proceedings of the

            Symposium and Forum Education in Materials Science, Technology and Engineering, 2007, 141-148.

      4.   Su CH, Sheu HS, Lin CY, Huang CC, Lo YW, Pu YC, Weng JC, Shieh DB, Chen JH, Yeh CS. Nanoshell magnetic resonance

            imaging contrast agents. Microprocesses and Nanotechnology 2007, Digest of Papers, 2007, 272-273.

      5.   Tai SP, Chu SW, Tsai, TH, Chen, SY, Shi XY, Chang CH, Wu YN, Shieh DB, Chen LJ, Prasad MR, Lin KJ, Sun CK. Molecular    

            imaging of cancer cells using plasmon-resonant- enhanced third-harmonic-generation microscopy with silver nanoparticles. 2005

            Conference on Lasers & Electro-Optics (CLEO), Vols 1-3, 2005, 1521-23.
　 　

(1) 國際會議: Oral presentation

      1.  Shieh DB. Theranostics by combined photoacoustics molecular imaging photothermal therapy and photonic genetic manipulation. SPIE

           Optics+Photonics—for the Latest Research in Solar, Nano, Optical, and Photonics Technologies and Applications. San Diago, CA,  

           USA, 2010 Aug.

      2.  Shieh DB. Gelsolin expression is associated with oral cancer drug resistance. 88th General Session & Exhibition of the IADR

           (International Association for Dental Research), Barcelona, Spain, 2010 Jul.

      3.  Shieh DB, Tsai TL, Su WC, Hwu JR. Photonic manipulation of gene silencing by ATLANS technology. New Zealand- Taiwan

           Symposium on Nanotechnologies for Bio-imaging, Sensing, and Diagnosis. Christchurch University, Christchurch, New Zealand, 2010

           Apr. ( Invited speaker)

      4.  Shieh DB, Tsai TL, Su WC, Hwu JR. Photonic manipulation of gene silencing by ATLANS technology. New Zealand- Taiwan

           Symposium on Nanotechnologies for Bio-imaging, Sensing, and Diagnosis. Wellington, New Zealand, 2010 Apr. ( Invited speaker)

      5.  Shieh DB. Tsai TL, Su WC. Simultaneous Precision Multi-attack of Target Gene Sequences by ATLANS Nanoparticles. 87th

           Taiwan/U.S. Air Force Nanoscience Workshop. Chiao Hsi, Yi Lan, Taiwan, 2010 Apr.

      6.  Shieh DB. Gold Nanoparticles in Cancer Theranostics and Photonic Manipulation of Gene Expression. UW-NCKU Bilateral workshop  

           in Nano/Bio-Photonics, Tainan, Taiwan, 2010 Mar.

      7.  Shieh DB, Wu YN, Li IC, Chen DH, Zheng R, Yang W, Ratinac K, Braet F. Assessment of iron-core-gold-shell nanoparticles as

           potential novel anti-cancer agents: An in vitro and in vivo study. ICONN 2010- 2010 International Conference On Nanoscience and

           Nanotechnology, Sydney, Australia, 2010 Feb.

      8.  Tsai TL, Yang YSS, Chuang KS, Hwu JR, Shieh DB*. The Artificial Targeting Light Activated Nanoscissors for Gene Expression

           Management at Genome Level. 2009 MRS Fall Meeting－

           Nanobiotechnology and Nanobiophotonics：Opportunities and Challenges－Applied Bionanosystems II, Boston, MA, USA, 2009

           Nov-Dec.

      9.  Shieh DB. In Vivo Molecular Photoacoustic Imaging Combined Targeted Therapeutics. BIT’s 2nd Annual Congress and Expo of

           Molecular Diagnostics (CEMD-2009)－ New Leadership of Personalized Medicine, Beijing, China, 2009 Nov. (Invited speaker)

      10.  Shieh DB. Pas de Deux: Integrated Multiplexed Cancer Molecular PA Imaging and LIH. 2009 Taiwan Nano—奈米科技產學研究

            合作推動論壇-奈米技術現況與未來趨勢系列論壇：奈米科技在臨床醫學的應用與展望，Taipei, Taiwan, 2009 Oct. (

             Invited speaker)

      11.  Shieh DB. Pas de Deux and Pas de Trois: Integrated Cancer Molecular Imaging and Therapy at Nano Scale. 2009 International

             Workshop on Nano Biomedicine. National Cheng Kung University, Tainan, Taiwan, 2009 Aug. ( Invited speaker & Oral Session

             Chair)

      12.  Shieh DB. Self-assembled targeting nanoprobes for cancer molecular imaging. The 11th International Congress on Amino Acids,

             Peptides and Proteins, Vienna, Austria, 2009 Aug. (Invited speaker)

      13.  Shieh DB. Pas de Deux: Integrated Multiplexed Cancer Molecular PA Imaging and LIH. The 7th Cross-Strait Workshop on

             Nanoscale Science and Technology, Guiyang, China, 2009 July. (Invited speaker)

      14.  Shieh DB, Wu PC, Cheng FY, Yeh CS. Targeting Oral Cancer lesion in vivo with modularly designed magnetite nanoparticles.

             Second World Congress of the International Academy of Oral Oncology (IAOO), Toronto, Canada, 2009 July.

      15.  Shieh DB. Molecular Photoacoustic Imaging Using Gold Nanoprobes. First World Congress of International Academy of

             Nanomedicine (IANM), Sanya, China, 2009 June. ( Invited speaker)

      16.  Shieh DB, Tsai TL, Su WC, Hwu JR. Targeted light-activated nanoscissor for gene specific silencing in oral cancer. 87th General

             Session & Exhibition of the IADR (International Association for Dental Research), Miami, USA, 2009 Apr.

      17.  Shieh DB. Photoacoustic Molecular Imaging for Cancer Diagnosis. Taiwan (NCKU)-New Zealand Symposium on Nanotechnologies

             for Bio-imaging, Sensing, and Diagnosis. National Cheng Kung University, Tainan, Taiwan, 2008 Nov. ( Invited speaker)

      18.  Shieh DB. Molecular Imaging of Cancers in vivo by Modularly Designed Magnetite Nanoprobes. 7th International Symposium on  

             Nano-Biomedical Engineering. National Cheng Kung University, Tainan, Taiwan, 2008 Oct. ( Invited speaker)

      19.  Shieh DB, Ding AA, Li PC, Wei CW, Wang CRC, Poe C. Photoacoustic Molecular Imaging with Simultaneous Intravascular and

             Extravascular Targeting. 2008 World Molecular Imaging Congress. Nice, France, 2008 Sep. ( Invited speaker)

      20.  Shieh DB, Tsai TL, Su WC. Photoactive Compound-Triplex-Forming Oligonucleotide Linked Gold Nanoparticle as an Artificial Gene

             Specific DNA Cleaver Assembly. IEEE Nano 2008—8th International Conference in Nanotechnology. Arlington, Tx, USA, 2008

             Aug.

      21.  Shieh DB. Translational Nanomedicine. 2008 Emerging Information and Technology Conference (EITC 2008). National Cheng Kung

             University, Tainan, Taiwan, 2008 Jun. ( Invited speaker)

      22.  Shieh DB. Translational Medicine. MR Molecular Imaging Symposium--From Bench to Bed. National Taiwan University Hospital,

             Taipei, Taiwan,2008 Jun. ( Invited speaker)

      23.  Shieh DB. Translational Nanomedicine – potential in-cell surgery and theranostics. Partnership for International Research, Innovation

             and Development, University of Ottawa-Taiwan International Workshop on Nanotechnology. Ottawa, Canada, 2008 Mar. ( Invited

             speaker)

      24.  Shieh DB. Nanomedicine: A Crossdiscipline Pathway Toward Improved Clinical Diagnosis and Therapeutics. 2007 International

             Conference on Bionano Sciences ( 2007-ICONBS) 2007 Dec. (Invited speaker)

      25.  Shieh DB. Translational Research in Nanobioimaging and therapeutics.台日雙邊奈米前瞻研究與教育研討會. Tainan, Taiwan,

             2007 Dec.( Invited speaker)

      26.  Shieh DB, Whitefield D, Wang SJ, Chen CJ, Yu K, Thirumalai D, Yeh CS, Chang JB, Su WC, Abedelnasser A, Li PC, Dong CY.

             Nanoparticles for Combined Targeting Diagnosis and Therapy. Canada-Taiwan Joint Workshop on Emerging Photonic Applications in

             Medicine, Taipei, Taiwan, 2007 Nov. ( Invited speaker)

      27.  Shieh DB. Functional nanomaterials for theranostic applications. The Seventh Annual Emerging Information Technology Conference

             (EITC-2007), Princeton, USA, 2007 Aug. (Invited speaker)

      28.  Shieh DB, Yeh CS, Li PC, Chen DH, Wang CJ, Sun CK, Tzeng Y. Functional nanoparticles for theranostic applications. The 7th

             IEEE International Conference on Nanotechnology (IEEE-NANO 2007 Technical Digest), Hong Kong, China, 2007 Aug. (Invited

             speaker)

      29.  Shieh DB, Yeh CS, Li PC, Chen DH, Wang CJ, Sun CK, Tzeng Y. Functional nanoparticles for theranostic applications. Engineering

             Conference International 2007 (ECI 2007) - Nanoscience and Nanotechnology for Biological/Biomedical/Chemical Sensing, Hong

             Kong, China, 2007 Jun. (Invited speaker)

      30.  Shieh DB, Wu PC, Tsai TL, Wang WS, Wong TY, Yeh CS. Porous Iron Oxide Nanorods for the Theranostics of Oral Cancers. 85th

             General Session & Exhibition of the IADR (International Association for Dental Research), New Orleans, USA, 2007 Mar.

      31.  Shieh DB, Whitefield D, Wang SJ, Chen CC, Yu K, Thirumalai D, Yeh CS, Chang JB, Su WC, Abedelnasser A, Li PC, Dong CY.

             Nanoparticle Enabled Theranostics of Cancer. The 5th Cross-Strait Workshop on Nanoscale Science and Technology, Hong Kong,  

            China, 2006 Dec. (Invited speaker)

      32.  Shieh DB, Yeh CS, Tzeng Y. Modular Designed Functional Nanoparticles for Clinical Theranostics. The MRS 2006 Fall Meeting-

             Session D2: Nanoparticles, Boston, MA, USA, 2006 Nov.( Invited paper)

      33.  Shieh DB. Translational Research in Nanobioimaging and therapeutics.台日雙邊奈米前瞻研究與教育研討會. Tokyo, Japan,

             2006 Nov.( Invited speaker)

      34.  Shieh DB. Education in Nanobiomedicine : Cross the barrier of discipline. Taiwan Nano-X 2006 台灣奈米國際週-亞洲奈米論壇-

             奈米人才培育研討會. Taipei, Taiwan, 2006 Sep.

      35.  Shieh DB. Nanotechnology Enabled Theranostics-A Cross Discipline Approach in Taiwan.以跨領域策略整合奈米技術於臨床診

            療. 第21屆近代工程技術討論會（METS 2006）Taipei, Taiwan, 2006 Sep. (Invited speaker)

      36.  Shieh DB. Bionanomaterials and Nanobiomedicine. The Sixth Annual Emerging Information Technology Conference (EITC-2006),

             Dallas, USA, 2006 Aug. (Invited speaker & Oral Session Chair)

      37.  Shieh DB, Shao CY, Huang PY, Chang HJ, Wong TY, Chang HC. Gelsolin modulates biophysical properties and invasiveness of oral

             cancer cells. 84th General Session & Exhibition of the IADR (International Association for Dental Research), Brisbane, Australia,

             2006 Jun-Jul. (Oral Session Chair)

      38.  Shieh DB, Yeh CS, Chang WC, Tzeng YH. The Integration of Nanotechnology and Biomedicine for an Educational Program on

             Nano-Biomedicine at National Cheng Kung University in Taiwan. Symposium W: Education in Materials Science and Engineering. The

             E-MRS 2006 Spring Meeting (E-MRS - IUMRS - ICEM 06), Nice (France), 2006, May-June. (Invited speaker)

      39.  Shieh DB. Nanotechnology in the diagnostics and therapeutics of oral diseases. 2006台灣國際口腔癌及檳榔研討會, Taipei,

             Taiwan, 2006, Mar. (Invited speaker)

      40.  Shieh DB. Nanomedicine: A Crossdiscipline Pathway Toward Improved Clinical Diagnosis and Therapeutics. 1st IEEE International

             Conterence on Nano/Micro Engineered and Molecular Systems, Zhuhai, China, 2006 Jan. (Invited speaker & Oral Session Chair)

      41.  Shieh DB, Chen CC, Wei YH, Chang HY. Occupational exposure of N, N-dimethylformamide Is associated with mitochondrial DNA

             damage. Mitochondria and Life 2005. The 3rd Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM)  

             and 5th Scientific Conference of the Japanese Society for Mitochondrial Research and Medicine (J-mit), Tokyo, Japan, 2005 Dec.

             (Invited speaker)

      42.  Shieh DB. Nanotechnology in the Diagnostics and Therapeutics. 2005 Nano Bioengineering International Symposium-- Quantum Dots

             for Live Cells, in vivo Imaging, and Diagnostics, Chung Yuan Christian University, Taiwan, 2005 Dec. (Invited speaker)

      43.  Shieh DB, Wu CL, Chen DH, Chou CH, Yeh CS. Nanoparticles in the Diagnostics and Therapeutics. The 4th Cross-Strait

             Workshop on Nanoscale Science and Technology, Lijiang, Yunnan, China, 2005 Aug. (Invited speaker)

      44.  Shieh DB. Targeted simultaneous multi-gene delivery utilizing tumor specific peptide functionalized nanoparticle with structured DNA

             complex. NSC-NRC-ITRI Trilateral Workshop on Nanoscience and Nanotechnology, National Science Council, National Research

             Council Canada, Industrial Technology Research Institute, National Nanoscience and Nanotechnology Program Office, Canadian

             Trade Office in Taipei, Taipei, Taiwan, 2005 Jun.

      45.  Shieh DB, Shau JY, Chen IW, Wong TY, Wei TY, Chung CH, Jin YT. Tissue expression profile of gelsolin during oral carcinogensis

             progression and its functional implications. 10th International Congress on Oral Cancer, Island of Crete, Greece, 2005 Apr. The Best  

             Basic Science Award in 10th ICOOC (supported by WHO, ICOOC, HATMC, HCS).

      46.  Shieh DB , Shi XY, Lian CC, Chang CH, Chen DH. Fe@Au nanoparticle displays selective anti oral cancer effect. International

            Association for Dental Research--83rd IADR/ 34th AADR/ 29th CADR, Baltimore, USA, 2005 Mar.

      47.  Shieh DB. Impact of nanotechnology to clinic medicine. 2003 International workshop on NanoBiotechnology, Industrial Technology

             Research Institute, Hsin-Chu, Taiwan, 2003 Mar. (Invited speaker)

      48.  Shieh DB, Chou WB, Jin YT, Wei YH. Mitochondrial DNA 4977 bp deletion in paired oral cancer and precancer lesions revealed by

             laser microdissection and real time quantitative PCR. The first scientific meeting of Asian Society for Mitochondrial Research and

             Medicine, Seoul, Korea, 2003 Feb. (Invited speaker)

(2) 國際會議論文: International conference & proceeding papers

      1.  Abedini MR, Ding AA, Cao M, Shieh DB, Tsang BK. Gelsolin modulates cisplatin sensitivity: A determinant for chemosensitivity in

           human cancer. The 5th Conference of Canadian Conference on Ovarian Cancer Research 2010, CCOCR, Toronto, ON, Canada,

           2010 May.

      2.  Tsai MR, Chen SY, Shieh DB, Lou PJ, Sun CK. In vivo optical virtual biopsy of human oral cavity with harmonic generation

           microscopy. 2010 SPIE Photonics West, San Francisco, USA, 2010 Jan.

      3.  Chang CM, Chiou LF, Lin CC, Shieh DB*, Lee GB. Three-Dimensional Microfluidic Chip for Extraction of Mitochondrial DNA. The

            6th Conference of Asian Society for Mitochondrial Research and Medicine, Taipei, Taiwan, 2009 Oct-Nov.

      4.  Shieh DB, Tsai TL, Chuang KS, Yeh CS, Tzeng Y, Li KTJ, Su WC, Hwu JR. Targeted photonic manipulation of DNA by

           nanoscissors. 2009 NSTI Nanotechnology Conference and Trade Show, Houston, Texas, USA, 2009 May.

      5.  Shieh DB, Hsieh CC, Huang SB, Wu PC, Lee GB. A Microfluidic-based Cell Culture Platform for Cellular and Sub-Cellular Imaging.

           The 4th Annual IEEE International Conference on Nano/ Micro Engineered and Molecular Systems ( IEEE-NEMS 2009). Shenzhen,

           China, 2009 Jan.

      6.  Huang CH, Lin HY, Lin CH, Shieh DB, Chui HC. Near field distribution of localized SP coupling in isolated and collective metal

           nanoparticle arrays. Frontiers in Optics 2008 – The 92nd Annual Meeting * Laser Science XXIV. Illumination Modeling: Simulation and

           Perceptions of Lit and Unlit Objects. Plasmonics and Metamaterials * Optical Fabrication and Testing. Rochester, NY, USA, 2008

           Oct.

      7.  Lin HY, Chang CH, Huang CH, Lin CH, Shieh DB, Chui HC. The phase sensation of near-field optical enhancement in a metal

           nanoparticle. Frontiers in Optics 2008 – The 92nd Annual Meeting * Laser Science XXIV. Illumination Modeling: Simulation and

           Perceptions of Lit and Unlit Objects. Plasmonics and Metamaterials * Optical Fabrication and Testing. Rochester, NY, USA, 2008

           Oct.

      8.  Shieh DB, Ding AA, Wu YN, Chen YY, Wang CRC. Combined Multi-target Molecular Ultrasonography and Photothermal Therapy

           Using Cancer Targeting Gold Nano Rod Probes. IEEE Nano 2008—8th International Conference in Nanotechnology. Arlington, Tx,

           USA, 2008 Aug.

      9.  Shieh DB, Wu PC, Tsai TL, Cheng FY, Yeh CS. An Iron Oxide Nanoparticle Drug Carrier for Improved Cancer Chemotherapy in

           Drug Resistance Line. IEEE Nano 2008—8th International Conference in Nanotechnology. Arlington, Tx, USA, 2008 Aug.

      10.  Ding AA, Shieh DB. HER-2 Antibody Conjugated Gold Nano Rod for in Vivo Photothermal Therapy. IEEE Nano 2008—8th

             International Conference in Nanotechnology. Arlington, Tx, USA, 2008 Aug.

      11.  Wang PW, Chen CH, Shieh DB. Oxidized LDL as an Effective Anti-Cancer Bio Nanoparticle. IEEE Nano 2008—8th International

             Conference in Nanotechnology. Arlington, Tx, USA, 2008 Aug.

      12.  Chen YL, Zhang JB, Yeh CS, Hsieh WY, Shieh DB*. Construction of Single-domain Antibody- nanoparticle Complex Library

             System for MRImaging of Cancers. 86th General Session & Exhibition of the IADR (International Association for Dental Research),

             Toronto, Canada, 2008 Jul.(2008 IADR Diagnostic Sciences Group Student Award)

      13.  Shieh DB, Jeng YR, Lin TT, Chang HJ, Wong TY. Nanomechanical properties of tooth surface upon anti-caries treatment. 86th

             General Session & Exhibition of the IADR (International Association for Dental Research), Toronto, Canada, 2008 Jul.

      14.  Tsai TL, Chuang KS , Hwu JR, Yeh CS, Su WC, Shieh DB*. Modification of warhead with triplex-forming oligonucleotide (TFO)

             functionalized gold nanoparticles for STAT3 gene clervage.IIAS 2008 / NSC-NSF SBE&S Workshop, NCKU, Tainan, Taiwan,

             2008 Feb. (the Best Poster  Presentation Award)

      15. Wu YN, Shi XY, Chiang IC, Chen DH, Shieh DB*. The implication of the superparamagnetic core-shell nanoparticle, Fe@Au, to be a

            novel anticancer agent. IIAS 2008 / NSC-NSF SBE&S Workshop, NCKU, Tainan, Taiwan, 2008 Feb. (Poster Competition – the

            Second Prize Award)

      16.  Wu PC, Tsai TL, Cheng FY , Yeh CS, Shieh DB*. An alternative drug carrier of based Iron Oxide nanoparticles for cancer therapy.

             IIAS 2008 / NSC-NSF SBE&S Workshop, NCKU, Tainan, Taiwan, 2008 Feb.

      17.  Chen YL, Zhang JB, Yeh CS, Hsieh WY, Shieh DB*. Construction of Single-domain Antibody- nanoparticle Complex Library

             System for MRImaging of Cancers. IIAS 2008 / NSC-NSF SBE&S Workshop, NCKU, Tainan, Taiwan, 2008 Feb.

      18.  Wei CW, Liao CK, Chen YY, Wang CRC, Ding AA, Shieh DB, Li PC. In vivo Photoacoustic Imaging with Multiple Selective

             Targeting Using Bioconjugated Gold Nanorods. SPIE International Symposium on Biomedical Optics, San Jose, California, 2008 Jan.

      19.  Tsai TL, Chuang KS , Hwu JR, Yeh CS, Su WC, Shieh DB. Conjugation of Warhead Modified Triplex-Forming Oligonucleotide

             (TFO) with Gold Nanoparticles for Specific DNA Cleavage. 2007 International Conference on Bionano Sciences ( 2007-ICONBS),  

            Taipei, Taiwan, 2007 Dec. (Poster Presentation Award)

      20.  Su CH, Sheu HS, Lin CY, Huang CC, Lo YW, Pu YC, Weng JC, Shieh DB, Chen JH, Yeh CS. Nanoshell magnetic resonance

             imaging contrast agents. 20th International Microprocesses and Nanotechnology Conference, Kyoto, Japan, 2007 Nov.

      21.  Chen YL, Hsieh WY, Yeh CS, Zhang JB, Shieh DB. Construction of single-domain antibody- nanoparticle complex library system for

             theranostic of cancers. The Third Meeting of Asian Society of Oral and Maxillofacial Pathology, Taipei, Taiwan, 2007 Nov.

      22.  Wu PC, Cheng FY, Yeh CS, Shieh DB. An alternative Iron Oxide nanoparticles drug carrier of based for oral cancer therapy. The

             Third Meeting of Asian Society of Oral and Maxillofacial Pathology, Taipei, Taiwan, 2007 Nov.

      23.  Jeng YR, Mao CP, Lin TT, Shieh DB. Contact mechanics study in biotribology: A tissue engineering example. The ASME/STLE

             International Joint Tribology Conference, PTS A AND B, San Diego, CA, USA, 2007 Oct.

      24.  Shieh DB, Wu PC, Tai SP, Chiu FC, Wong TY, Sun CK. Higher harmonic generation imaging for oral diagnosis. The First World

             Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, Netherlands, 2007 May.

      25.  Wu PC, Su CH, Cheng FY, Weng JC, Chen JH, Yeh CS, Shieh DB. Modular designed nanoparticles for MRI diagnosis in oral

             cancer. The First World Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, Netherlands, 2007 May.

      26.  Tsai TL, Wu PC, Wang WS, Yeh CS, Shieh DB. Synthesis of porous iron oxide nanorods for drug delivery in oral cancer cells. The

             First World Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, Netherlands, 2007 May.

      27.  Chang  HJ, Shieh DB, Chang YC, Fanchiang JC, Wong TY. Biocompatibility and physical properties of collagen containing

             glassionomer. 84th General Session & Exhibition of the IADR (International Association for Dental Research), Brisbane, Australia,  

             2006 Jun-Jul. (Frechette Competition finalist)

      28.  Chen CC, Shieh DB, Shih TS, Tai HM, Chang HY. Mitochondrial DNA 4,977-bp deletion and mitochondrial DNA copy number in

             humans occupationally exposed to N,N-dimethylformamide. The First East Asia Conference of the ISEE, Taipei, Taiwan, 2006 Apr.

      29.  Li PC, Wei CW, Liao CK, Chen CD, Pao KC, Wang CR C, Wu YN, Shieh DB. Multiple targeting in photoacoustic imaging using

             bioconjugated gold nanorods. Proceedings of SPIE -- Volume 6086. Photons Plus Ultrasound: Imaging and Sensing 2006: The  

             Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860M (Mar. 6, 2006)

      30.  Su CH, Wu PC, Weng JC, Shieh DB, Yeh CS, Chen JH. The Modified Fe3O4-NH3+ with RGD-4C Ligand for Cancer Cell

             Targeting MR Contrast Agent, Proc 14th ISMRM Ann Meeting, Seattle, USA, 2006; No: 1829.

      31.  Tzeng Y., Chang SJ, Shieh DB, Yeh CS, Liao JD, and Liu CP. Center for Micro/Nano Science and Technology. 2006 Nano Tech,

             Tokyo, Japan, 2006 Feb.

      32.  ShiehDB, Wu YN, Yeh CL, Chang FY, Tzeng Y., Yeh CS. Synthesis of monoclonal antibody tagged iron-oxide nanoparticles and

             their biomedical applications. 2006 Nano Tech, Tokyo, Japan, 2006 Feb.

      33.  Shieh DB, Tai SP, Wu YN, Chang CH , Chen LJ, Lin KJ, Sun CK. Silver nanoparticle enhanced third-harmonic-generation system as

             a new diagnostic imaging tool for oral cancer. 10th International Congress on Oral Cancer, Island of Crete, Greece, 2005 Apr.

      34.  Shieh DB, Yeh CL, Weng JC, Wu YN, Chang CW, Yeh CS, Chen JH. Anti-Her-2 Monoclonal Antibody Conjugated Non-polymer

             Coated Iron Oxide Nanoparticle as Dual Purpose Contrast Agent for Targeted Anti-cancer Therapy and MR Imaging. The Third Asia

             Pacific Bioinformatics Conference, Singapore, 2005.

      35.  Su CH, Wu YN, Weng JC, Cheng FC, Yeh CS, Shieh DB, Chen JH. The New Strategy for USPIO Steals in Hepatic MR Imaging,

             The Fourth Annual Meeting of The Society for Molecular Imaging, Cologne, Germany, 2005; No. 90.

      36.  Shieh DB, Shi XY, Lian CC, Chen DH. The Fe@Au core-shell nanoparticle with distinct selective cancer cell cytotoxic effect, Nano

             Tech 2005, Tokyo, Japan, 2005 Feb.

      37.  Sun CK, Tai SP, Chen SY, Tsai TH, Chu SW, Lee WJ, Hsieh CS, Ko CY,. Hu CH, Lin CY, Tsai HJ, and Shieh DB. Optical Higher

             Harmonic Generation in Biotissues and Its Application for Bioimaging. The Annual Meeting of the Spectroscopic Society of Japan, pp.

             61-62, Tokyo, Japan, 2005.

      38.  Sun CK, Tai SP, Tsai TH, Chen SY, Lee WJ, Liao YH, and Shieh DB. Higher Harmonic Generation Biopsy. Focus on Microscopy,

             pp. 65, Jena, Germany, 2005.

      39.  Cheng FY, Shieh DB and C.S. Yeh. Non- polymer Coated Fe 3 O 4 Aqueous Dispersion with NH 3 +-surface Modification as New

             Magnetite Nanoparticles and Their Biomedical Applications. 5th IEEE Conference on Nanotechnology, Japan, 2005 July.

      40.  Tai SP, Chu SW, Tsai, TH, Chen, SY, Shi XY, Chang CH, Wu YN, Shieh DB, Chen LJ, Prasad MR, Lin KJ, Sun CK. Molecular

             imaging of cancer cells using plasmon-resonant- enhanced third-harmonic-generation microscopy with silver nanoparticles. Conference

             on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference/Photonic Application, Systems and Techn, paper

             CWP6, Baltimore, MD, USA, 2005.

      41.  Shieh DB, Su CH, Chang FY, Wu CM, Wu MT, Yeh CS. Design of a novel non-polymer coated iron oxide nanoparticle and its

             application in hepatic MR imaging. MRI conference USA, 2004 Sep.

      42.  Su CH, Cheng FY, Yeh CS, Shieh DB. The Application of USPIO Nanoparticles in MR Image. 8th Asia-Pacific Conference on

             Electron Microscopy , Japan , 2004 June.

      43.  Cheng FY, Su CH, Yang YS, and Yeh CS, Tsau CY, Wu CL, Wu MT, Shieh DB. Preparation, Characterization and Cytotoxicity of

             Well-Dispersed Fe3O 4 nanoparticles in aqueous solution and their potential as contrast agents. Nanoparticles in Solution and Their    

             Potential as Contrast Agents. 8th Asia-Pacific Conference on Electron Microscopy, Japan, 2004 June.

      44.  Shieh DB, Lai HL, Wei YH, Jin YT. Analysis of Mitochondrial D-loop sequence and Mitochondrial DNA copy number in oral cancer

             and precancer tissues and cell lines, The 2nd Conference of Asian Society for Mitochondrial Research and Medicine, Taipei, Taiwan,

             2004 Apr.

      45.  Shieh DB, Su CH, Wu MT, Chang FY, Yeh CS. Superparamagentic nanorods without polymer coatingn as a new class of magnetic

             resonance imaging contrast agent. The 3rd Cross-Strait Workshop on Nano Science and Technology, Hwa-Lian, 2004 Apr.

      46.  Shieh DB, Su CH, Yeh CS, Wu MT, Wu CM, Wu CL. Nanotechnology applied to cancer diagnosis and therapy – the integration and

             the road map of NCKU biomedical nanotechnology group. US Air Force & Taiwan Nanoscience Initiative Workshop, 2004 Feb.

      47.  Chou WB, Shieh DB, Jin YT. Studies of mitochondrial DNA alterations in microdissected betel quid-related oral cancer and

             precancerous lesions, The 57th Annual meeting of American Academy of Oral and Maxillofacial Pathology, 2003 May.

      48.  Shieh DB, Chung CH, Wang TY, Tsai ST, and Jin YT. The integration and establishment of tissue bank and clinical in formatics of

             betel quid related oral lesions, The 23rd Asia Pacific Dental Congress & Annual Scientific Meeting and General Assembly of ADS-

             ROC, 2001 Apr.

      49.  Shieh DB, Jin YT, Wang TY,and Wang TH. Electrochemotherapy enhance the susceptibility of oral cancer cell to anti-cancer agents.

             The 23rd Asia Pacific Dental Congress & Annual Scientific Meeting and General Assembly of ADS-ROC, 2001 Apr.

 

(3) 國內會議: Oral presentation

      1.  Shieh DB. Cancer nanotechnology: translational approaches. 2010 Symposium on Translational Cancer Medicine at NCKU Medical

           Center. Tainan, Taiwan, 2010 May. ( Invited speaker)

      2.  Shieh DB. Translational Nanomedicine-theranostics from the bottom. KMU Cardiovascular Science Symposium 2009.(高醫心臟 血

           管醫學研討會), Kaohsiung, Taiwan,2009 Dec. ( Plenary Lecture)

      3.  Shieh DB. 轉譯奈米生醫導論.98年奈米化藥物、中藥、化妝品及食品之科技管理及法規人才養成計畫(四)- 轉譯奈米生

           物醫學應用研習會，Taipei, Taiwan, 2009 Jun. ( Invited speaker)

      4.  Shieh DB. 微奈米科技在生醫產業的應用與前瞻. 2009 Taiwan Nano—奈米科技產學研究合作推動論壇-奈米技術現況

           與未來趨勢系列論壇：生醫產業，Taichung, Taiwan, 2009 Jan. ( Invited speaker)

      5.  Shieh DB, Yeh CS, Li PC, Wang CRC. Translational Nanomedicine. 2008台灣醫學週(Taiwan Medical Week 2007) -台灣聯合醫

           學會第101屆總會學術演講會. 台灣醫學會，Taipei, Taiwan, 2008 Nov. ( Invited speaker)

      6.  Shieh DB. Translational Nanobiophotonics. 中華民國醫用雷射光電學會春季研討會, 2008 May. ( Invited speaker)

      7.  Shieh DB. 奈微尺度下的未來醫學. 2007台灣醫學週(Taiwan Medical Week 2007)-台灣聯合醫學會第100屆總會學術演講會

            -生物科技研習營-奈米生醫科技之新進展. 台灣醫學會&財團法人張昭鼎基金會，Taipei, Taiwan, 2007 Nov. ( Invited

            speaker)

      8.  Shieh DB. 奈米科技在診斷與治療上的應用，96年生醫奈米科技學術研討會，高雄醫學大學，Kaohsiung, Taiwan, 2007

           Sep. ( Invited speaker)

      9.  Shieh DB. 綜觀奈米再生醫學. 2006 奈米與再生醫學科技研討會 (2006 Symposium on Nanotechnology & Regenerative

           Medicine) 國立成功大學, Tainan, Taiwan, 2006 Mar. ( Invited speaker)

      10.  Shieh DB. 奈米科技在診斷與治療上的應用，生物奈米檢測研討會，國立高雄第一科技大學，Kaohsiung, Taiwan, 2005

             Nov. ( Invited speaker)

      11.  Shieh DB. 奈米材料在生物醫學上的應用. 第三屆南臺灣奈米材料研討會，成大與中山校際整合奈米科技研究中心、南

             區奈米科技前瞻人才培育中心, Tainan, Taiwan, 2005 Sep. ( Invited speaker)

      12.  Shieh DB. Nanotechnology in the Diagnostic Imaging and Therapeutics. 環境、健康與安全議題研討會，國科會奈米國家型科

             技計劃辦公室，行政院環境保護署，行政院衛生署，行政院勞工委員會主辦，台北，2005 July. ( Invited speaker)

      13.  Shieh DB. 奈米粒子在臨床醫學影像的發展. 2005奈米生醫光電研討會，國科會工程科技推展中心, Tainan, 2005 Mar. (

             Invited speaker)

      14.  Wu CL, Yeh CS, Shieh DB, Chen DH, Chou CH. A novel strategy in target specific gene transfer and gene therapy utilizing

             superparamagnetic nanoparticles. 2004奈米國家型科技計畫成果發表會, Taipei, 2004 Sep.

      15.  Shieh DB. The Application of Nanotechnology in MR Imaging. 奈米生醫研討會系列三-奈米生醫科技在醫學影像之應用, 奈

             米國家型科技計劃辦公室, Taichung, 2004 July. ( Invited speaker)

      16.  Shieh DB. 奈米技術、生物技術與臨床醫學之發展，奈米技術之分子診斷研討會，93年度教育部生物科技教育改進計

             畫分子檢驗資源中心，2004 May. ( Invited speaker)

      15. Shieh DB. 奈米粒子於臨床疾病之診斷與治療應用.奈米生醫研討會系列一-奈米粒子生物醫學應用及毒性探討, 奈米國

            家型科技計劃辦公室, Taipei, 2004 Feb. ( Invited speaker)

      16. Shieh DB. 奈米生物技術.產業高值化系列研討會-奈米科技商機與契機, 2003, Sep. 臺南縣政府主辦. ( Invited speaker)

      17. Shieh DB. Future perspectives of nanobiotechnology in clinical diagnosis and treatment. Annual Scientific Meeting and General

            Assembly of ADS-ROC, 2003 Sep.

      18. Chang YC, Shieh DB. A study in the biocompatibility and ultrastructure of a novel glass-ionomer-collagen composite. Annual Scientific

            Meeting and General Assembly of ADS-ROC, 2003 Sep.

      19. Shieh DB. Nanotechnology based clinical diagnosis and therapeutics applications – current development and future trend. Annual

            Scientific Meeting and General Assembly of AOP-ROC, 2002 Dec.

      20. Shieh DB, Jin YT. The integration and establishment of betel quid associated oral lesion bank and clinical informatics. National Science

            and Technology Program in Pharmaceutical and Biotechnology, Taipei, Taiwan, 2002 Dec.

      21. Shieh DB. Nanotechnology in biomedicine. 國科會南區微系統中心九十一年度成果發表會, Tainan, Taiwan, 2002 Nov.

      22. Shieh DB. Modulated multifunctional bioreactor and dynamic digital imaging system with versatile optical modules. 2002 年生技醫藥

            技術交易促進會研發成果發表會, Taipei, Taiwan, 2002 Nov.

      23. Yeh CS, Chen YH, Lee CW, Shieh DB. 水溶性磁性奈米粒子. 2002 年生技醫藥技術交易促進會研發成果發表會, Taipei,

            Taiwan, 2002 Nov.

      24. Shieh DB, Jin YT. The integration and establishment of betel quid associated oral lesion bank and clinical informatics. National Science

            and Technology Program in Pharmaceutical and Biotechnology, Tao-Yuan, Taiwan, 2002 Nov.

      25. Shieh DB. Tissue banking system in the post genomic age. 2nd NHRI Conference in Cancer Genomics. National Health Research

            Institutes, Tao-Yuan, Taiwan, 2002 Aug.

      26. Shieh DB. Nanotechnologies in biomedical applications. 第二屆生物微奈米技術研討會，國科會南區微系統中心, Tainan,

            Taiwan., 2002 May. ( Invited speaker)

 

(4) 國內會議: Poster

      1.  Tsai TL, Chuang KS, Hwu JR, Yeh CS, Li TJ, Shieh DB. Specific Gene Cleavage and Regulation by Photoactivated Gold

           Nanoscissors. Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2010 Jan.

      2.  Li TJ, Yang LS, Shieh DB. Cyclic Progression of Stem Cell Marker in Oral Cancer Cell. Eighteenth Symposium on Recent Advances in

           Cellular and Molecular Biology, Kenting, Taiwan, 2010 Jan.

      3.  Wu PC, Yang ZS, Ding AA, Wang CRC, Li PC, Shieh DB. In Vivo Photothermal Therapy of Oral Cancer Using Gold Nanorods  

           Targeting at Her-2. Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2010 Jan.

      4.  Shieh DB, Wu PC, Yang Z. Evaluation of Gold nanoparticle biodistribution in vivo with respect to size, shape and surface modifications.

           Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2010 Jan.

      5.  Chiou CY(邱朝陽), Lai YH(賴祐炫), Yang JT(楊鏡堂), Shieh DB(謝達斌). 疏水性長碳鏈分子自組裝單層膜表面之液珠操

           控. 中國機械工程學會第二十五屆全國學術研討會, 大葉大學, 彰化, 台灣, 2008.

      6.  Wu PC, Su CH, Cheng FY, Weng JC, Chen JH, Yeh CS, Shieh DB. The Magical Missile in Modular Design: Molecular Orientation

           Control over Nanoparticle Surface for Efficient Oral Cancer Targeted Molecular Imaging system and Therapy. Taiwan - U.S. Joint

           Workshop on Frontiers in Nanoscience, Taipei, Taiwan, 2006 Dec.

      7.  Tsai TL, Wu P C, Wang WS, Yeh CS, Shieh DB. Synthesis of Porous Iron Oxide Nanorods for Drug Delivery in Oral Cancer Cell.

           Taiwan - U.S. Joint Workshop on Frontiers in Nanoscience, Taipei, Taiwan, 2006 Dec.

      8.  Wu YN, Shau YH, Shi XY, Chiang IC, Chen DH, Shieh DB. The Implication of the Superparamagnetic Core-shell Nanoparticle,

           Fe@Au, to be a novel Anticancer Agent. Taiwan - U.S. Joint Workshop on Frontiers in Nanoscience, Taipei, Taiwan, 2006 Dec.

      9.  Wu P C, Tsai T L, Tai S P, Sun C K, Shieh DB. Development of harmonic generation imaging system for oral carcinogenesis.非侵入

           式口腔癌協振造影系統在口腔癌之應用, Annual Scientific Meeting and General Assembly of ADS-ROC, Taichung, Taiwan, 2006

           Aug.

      10.  Tsai T L, Wu P C, Wang W S, Yeh C S, Shieh DB. Synthesis of porous iron oxide nanorods for drug delivery to oral cancer cells.多

             孔性氧化鐵奈米管於攜帶藥物治療口腔癌上之應用, Annual Scientific Meeting and General Assembly of ADS-ROC, Taichung,

             Taiwan, 2006 Aug.

      11.  Ciou FJ, Wong TY, Huang JS, Chung CH, Shieh DB. Outcome of surgical treatment of oral squamous cell carcinoma in National

             Cheng Kung University Hospital.  國立成功大學附設醫院口腔鱗狀細胞癌手術治療之結果分析, Annual Scientific Meeting and

             General Assembly of ADS-ROC, Taichung, Taiwan, 2006 Aug.

      12.  Wu YN, Shi XY, Chiang IC, Chen DH, Shieh DB. The implication of the superparamagnetic core-shell nanoparticle, Fe@Au, to be

             an novel anticancer agent. 14th Chinese Society of Cell and Molecular Biology, Kenting, Taiwan, 2006 Jan.

      13.  Wu PC, Su CH, Cheng FY, Weng JC, Chen JH, Yeh CS, Shieh DB. The magical missile in modular design: Molecular orientation  

             control over nanoparticle surface for efficient oral cancer targeted molecular imaging and therapy. 14th Chinese Society of Cell and

             Molecular Biology, Kenting, Taiwan, 2006 Jan.

      14.  Shieh DB, Wu YN, Yeh CL, Chang FY, Yeh CS. Synthesis of monoclonal antibody tagged iron-oxide nanoparticles and their

             biomedical applications. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2005 Jan.

      15.  Su CH, Wu YN, Weng JC, Cheng FY, Yeh CS, Shieh DB, Chen JH. The New Strategy for USPIO Steals in Hepatic MR Imaging”,

             Conference on Biomedical Engineering Technology. Taoyuan, Taiwan, 2005; P3-015.

      16.  Shiao CY, Chen YW, Hwang WY, Shieh DB. A study in the function of gelsolin in oral cancer invasion adhesion and local motion.

             Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2005 Jan.

      17.  Chang CH, Chang YC, Chen DH, Shieh DB. Synthesis of a novel supermagnetic nanoparticles drug carrier and evaluation of their

             cancer therapeutic efficacy and MRI contrast effect. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology,

             Kenting, Taiwan, 2005 Jan.

      18.  Shieh DB , Shi XY, Lian CC, Chang CH, Chen DH. A novel oral cancer therapeutics strategy based on a bi-metalic magnetic

             nanoparticle. Annual Scientific Meeting and General Assembly of AOP-ROC, 2004 Nov.

      19.  Shi XY, Chen DH, Lian CC, Wu CL, Yeh CS, Chou CH, Shieh DB. Particle size and the surface structure of a core-shell

             paramagnetic nanoparticle influence their anti-cancer effect. Taiwan Nano Tech 2004, Annual technique report conference and

             international workshop (2004奈米國家型科技計畫成果發表會), Taipei, 2004 Sep.  

      20.  Chang YC, Shieh DB, Wu YN, Weng JC, Chen JH, Chen DH. Monodisperse Chitosan-bound Fe3O4 Nanoparticles with and

             without adsorbing Gd ions as MRI contrast agents. Taiwan Nano Tech 2004, Annual technique report conference and international

             workshop (2004奈米國家型科技計畫成果發表會), Taipei, 2004 Sep.

      21.  Shi XY, Lian CC, Chen DH, Shieh DB. A novel oral cancer therapeutics strategy based on a superparamagnetic core-shell

             nanoparticle anticancer agent complex. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan,

             2004 Feb.

      22.  Shiao CY, Shieh DB. A study in the effect of betel quid extract exposure to morphological alterations and dynamic cellular motility of

             normal, precancer, and oral cancer cells and the differential expression of cell motility and differential associated genes. Twelfth

             Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2004 Feb

      23.  Shieh DB, Chen IW, Wei TY, Jin YT. A study of gelsolin expression in oral carcinogenesis and the effects on cellular motility and

             differentiation. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan, 2003 Jan.

      24.  Shieh DB, Chen IW, Wei TY, Wong TY, Chung JH, Jin YT. Gelsolin expression profile is associated with oral carcinogenesis and  

             differentiation. 2nd NHRI Conference in Cancer Genomics. National Health Research Institutes, Tao-Yuan,Taiwan., 2002 Aug.

      25.  Huang TS, Shieh DB, Jin YT. The expression of vascular endothelial growth factor in oral squamous cell carcinomas in Taiwan. 2nd

             NHRI Conference in Cancer Genomics. National Health Research Institutes, Tao-Yuan, Taiwan, 2002 Aug.

      26.  Huang TW, Harn WM, Liu CW, Shieh DB. A design of digital imaging system and models for dental clinical training. Annual Scientific

             Meeting and General Assembly of ADS-ROC, 2002 May.

      27. Harn WM, Liu CW, Shieh DB. Apical calculus in persistent apical periodontitis: comparative ultrastructural and elemental analysis and

            case study. Annual Scientific Meeting and General Assembly of ADS-ROC, 2002 May.

      28. Hung MS, Shieh DB. Nanotechnology in biomedicine Research. National Chang-Kung University, Bioscience and Technology Center,

            Tainan, Taiwan., 2002 Apr.

      29. Chen YJ, Jin YT, Shieh DB, and Wu LW. The role of angiogenesis in oral cancer cells. Ninth Symposium on Recent Advances in

            Cellular and Molecular Biology, Kenting, Taiwan., 2001 Feb.

 

   1.  Li PC, Shieh DB, Wang CRC, “Nanoparticle design for in vivo molecular imaging with

           photoacoustics”, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (Invited, in preparation).

      2.  吳炳慶、謝達斌(民96)，奈微米生醫晶片(專論)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計畫」，

           生醫奈米科技教學資源中心主編，11月初版，p183-194.

      3.  吳炳慶、謝達斌(民96)，生醫奈米的科技產業觀(專論)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計

            畫」，生醫奈米科技教學資源中心主編，11月初版，p224-234.

      4.   張佑民、謝達斌(民96)，奈米粒子的體外毒性測試(實驗)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導

            型計畫」，生醫奈米科技教學資源中心主編，11月初版，p295-297.

      5.  謝達斌、楊鏡堂、楊宗翰、方偉峰(民96)，微流體生物晶片實作與應用(實驗)，“生醫奈米科技”，教育部「生物及醫學

           科技人才培育先導型計畫」，生醫奈米科技教學資源中心主編，11月初版，p304-322.

      6.  謝達斌(民94, 2008)，奈米生醫(應用篇)，“奈米科技－基礎、運用與實作”，南區奈米科技K-12教育發展中心，丁志明

           等編著，高立出版，p321-340, ISBN: 9789864122257.

      7.  傅昭銘、謝達斌(民94, 2008)，奈米顆粒生醫應用(實作篇)，“奈米科技－基礎、運用與實作”，南區奈米科技K-12教育

           發展中心，丁志明等編著，高立出版，p373-380, ISBN: 9789864122257.

      8.  Shieh DB(1997), Molecular Genetic Features Affecting The Prognosis in Stage I Non-Small-Cell Lung Cancer: activating mutations of

           K-Ras; loss of heterozygosity at sites on 3p, 5q, 8p, 9p, 11p, and 17p; and expression of cell-motility-related proteins. D.M.Sc. thesis.

受邀論文(Invited Article)：

      1.  Shieh DB*, Li PC, Wang CRC. Nanoprobe Opens New Era in Photoacoustic Medicine (奈米探針開創光聲醫療). Scientific

           America Chinese Edition (科學人, ISSN:1682-2811), Vol. 86, pp. 102-105, 2009 Apr.

      2.  Wu PC, Wang CRC, Li PC, Shieh DB*. Biological Stealth Gold nanorod platform based molecular photoacoustic imaging (金奈米生

           物隱形探針於光聲造影上的應用). Taiwan Nano Newsletter (台灣奈米會刊) , Vol. 19, pp.    , 2010 Jan.

      3.  Shieh DB*, Peng SR, Jeng YR. 細胞的物理與機械特性對生理的效應, 科儀新知, Vol. 31(4), pp. 57-63, 2010 Feb.

      4.  Shieh DB*, Lee YY, Tsai TL, Yeh CS. The application of Gold nanoparticles in Biomedicine. (金奈米粒子於生物醫學上的應用).

           化學 Chemistry-奈米生醫材料專輯報導(中國化學會化學季刊), Vol. 68(1), pp. 11-20, 2010 Mar.
　 　

      1.  “具水溶性及分散性之氧化鐵奈米粒子及其製造方法”,葉晨聖,陳毓宏,李家瑋,謝達斌 ,R.O.C. patent, #188278,

           2003/10/01~2022/12/08 .

      2.  “水溶性及分散性之氧化鐵奈米粒子的製備與作為磁共振造影顯影劑的應用”,葉晨聖,鄭豐裕,謝達斌,吳昭良, R.O.C.

             patent, #202070, 2004/05/21~2023/07/30.

      3.  “Method for preparation of water-soluble and dispersed Iron Oxide nanoparticles and application there of ”, Yeh CS, Cheng FY, Shieh

             DB, Wu CL, German patent, #102004035803, 2007/01/18~2022/01/18.

      4.  “鐵/金核殼型複合奈米粒子於治療腫瘤之用途”, 陳東煌, 謝達斌, 施宣宇, 連昭晴, 吳昭良, 葉晨聖, 周辰熹, R.O.C. patent,

           發明第 I  295177號, 2008/04/01~2025/01/12.

      5.  “奈米粒子及長鏈分子自組裝製作可控親疏水性介面之方法(A Novel Method of Self-Assembling Nanoparticles or Long Chain

           Molecules for the Formation of Surfaces with Controllable Wettability)”, 謝達斌, 楊鏡堂, 蕭宇宏, 楊宗翰, 申請中華民國發明專

           利(& UA Patent). (申請案號: 096114774, 2007/04/26).

      6.  “生物自組裝操控液珠及檢測之方法及裝置 (A Novel Method and Control Devices for Droplet Manipulation and Detection by

           Biomolecule Self Assembly)”, 楊鏡堂, 謝達斌, 邱朝陽, 楊宗翰, 張佑民, 陳逸臨, 申請中華民國發明專利(& UA Patent) (申請

           案號: 096114775, 2007/04/26).

      7.  “一種新穎電磁場調控表面親疏水性之方法及裝置(A Novel Method and Control Devices for Changing Wettability on Solid

           Surface by Electric or Magnetic field)", 楊鏡堂, 謝達斌, 楊宗翰, 方偉峰, 陳逸臨, 張佑民, 申請中華民國發明專利(& UA

           Patent) (申請案號: 096114772, 2007/04/26).

      8.  “以奈米自組裝製造非均勻表面性質奈微米粒子之方法(A Novel Method for Producing Nano and Micro particles with

           Nonhomogeneous Surfaces by Nano Self Assembly)”, 謝達斌, 楊鏡堂, 吳炳慶, 張佑民, 方偉峰, 邱朝陽, 申請中華民國發明專

          利(& UA Patent) (申請案號: 097102122, 2008/01/21).

      9.  “一種具超高解析度奈微米顯示元件之裝置(A Novel Fluorescent Device with Ultra-Resolution and Its Application)”, 楊鏡堂, 謝

           達斌, 方偉峰, 邱朝陽, 蔡宗霖, 吳亞娜, 申請中華民國發明專利(& UA Patent) (申請案號: 097102124, 2008/01/21).

      10.  “利用模組式奈米粒子進行生物檢測之方法及其套組(Bio-Detecting Method by Utilizing Modular-Designed Nanoparticles and

             Kit thereof)”, 吳炳慶, 謝達斌, 鄭豐裕, 葉晨聖, Jianbing Zhang, 申請中華民國發明專利 (申請案號: 097116609, 2008/05/06).

      11.  “類核苷酸化合物之載體及包含該載體之寡核酸-奈米粒子複合體”, 謝達斌,葉晨聖,陳東煌,吳亞娜, 吳炳慶, 申請中華民

            國發明專利 (申請案號: 095101409, 2007/01/21).

      12.  “建立快速配對合成之模組式設計功能性奈米粒子庫之方法暨生物醫學應用(Establishment of efficient fabrication system for

             modular Designed targeting Nanoparticle Library and its biomedical applications)”, 謝達斌, 葉晨聖, 鄭豐裕, 吳炳慶, Jianbing

             Zhang, 申請中華民國發明專利.

      13.  “以模組化設計標的之奈米粒子之設計製作以及其在分子影像暨治療之應用(Modular Designed Nanoparticles for molecular

             imaging and therapeutic applications)”, 吳炳慶, 謝達斌, 鄭豐裕, 葉晨聖, Jianbing Zhang, 申請中華民國發明專利.

      14.  “核酸切割組合物及其用於基因治療之方法(Nucleic Acid Cleavage Composition and Gene Therapy by Using the same)” , 謝達

             斌, 蔡宗霖, 胡紀如, 莊高樹, 蘇五洲, 申請中華民國發明專利.

      15.  “核酸切割套組及核酸切割檢驗裝置 核酸切割組合物及其用於基因治療之方法(NUCLEIC ACID CLEAVING KIT AND

             NUCLEIC ACID CLEAVE-DETECT APPARATUS)”, 謝達斌, 蔡宗霖, 胡紀如, 莊高樹, 蘇五洲, 申請中華民國發明專利.

      16.  “建立光學儀器(GeneEraser)來激發具有核甘酸切割功能性之奈米粒子暨生物醫學應用”, 謝達斌, 李宗儒, 蔡宗霖, 申請

            中華民國發明專利.

      17.  “電磁波照射裝置/ ELECTROMAGNETIC WAVE IRRITATING DEVICE”, 謝達斌, 申請中華民國發明專利.

      18.  “利用’生化自組裝’技術製作生化薄膜之感測裝置” , 謝達斌, 楊鏡堂,許妙行,呂虹靜, 申請中華民國發明專利.

      19.  “以雙邊表面不對稱修飾的奈米粒子製備發光元件之技術” , 謝達斌, 楊鏡堂, 呂虹靜,許妙行, 申請中華民國發明專利.

      20.  “含膠原蛋白之玻璃離子體之製備”, 謝達斌, 張欣如, R.O.C. patent, 申請中華民國發明專利.

      21.   “奈米粒子傳輸載體”, 胡紀如, 林育生, 喬瑟夫, 許銘華, 鄭豐裕, 葉晨聖, 蘇五洲, 謝達斌, 申請中華民國發明專利.

      22.   “以微處理器為基礎的非侵入式腫瘤偵測器/ The Microprocessor Based Non-invasive Tumor Detector”, 詹寶珠, Britton

              Chance, 謝達斌, Shoko Chance, 申請中華民國發明專利.

      23.   “微環境操控之智慧型自我吸附微奈米球體之製備”, 謝達斌, 張欣如. (In preparation)

      24.  “混合銀奈米之長效抗菌性牙科填補材料之製備與其它”, 謝達斌, 李士元. (In preparation)

      25.  “Preparation of a novel targeting Au nanorod with tunable SPR frequency and high cancer cell targeting”, Wang CRC, Li PC, Shieh

             DB. (In preparation)

      26.  “An advanced photoacoustic molecular imaging method”, Wang CRC, Li PC, Shieh DB. (In preparation)

      27.  “Integrated photothermal therapy using a novel targeting Au nanorod and an illumination device”, Wang CRC, Li PC, Shieh DB. (In

              preparation)

      28.  “Preparation of a novel Au@SiO2@Au rod with tunable SPR frequency and high stability”, Wang CRC, Li PC, Shieh DB. (In

             preparation)
　 　

      1.  臨床導向癌症奈米科技:同步多層次基因藥物調控及顯影之智慧型靶向奈米膠囊 Cancer nanotechnology toward

           clinical applications: smart targeting nanocapsule for simultaneous multi-level genetic/drug manipulation and diagnostic imaging of

           malignant diseases. (奈米國家型計劃-學研合作計劃)(總主持人) (2009.08-2012.07) (NSC 98-3114-M-006-002-, 99-

           2120-M-006-005-, 100-2120-M-006-002-)

      2.  以奈米探針整合倍頻光聲並微光學斷層掃描之多重尺度多式癌症分子造影 Nanoprobes enabled multi-scale multi-

           modal molecular imaging of cancers by combined higher harmonics photoacoustics and optical-MicroCT imaging. (NSC –NRC

           雙邊合作計畫) (2009.04-2012.03) (NSC 98-2218-E-006-008-MY3)

      3.  以中空及多孔洞奈米粒子開發口腔癌診斷及治療之新平台Development of novel oral cancer diagnosis and therapeutic

           platform based on hollow porous. (2007.08-2008.07) (2008.08-2011.07) (NSC96-2314-B-006-009) (97-2314-B-006-040-

           MY3)

      4.  癌細胞之分子造影：奈米子與奈米粒子之整合研究Molecular Imaging for Cancer Diagnostics: Nanobodies meet

           Nanoparticles. (NSC95-2120-M-006-) (NSC-ITRI-NRC三邊合作計畫) (2006.01-2009.03)

      5.  生物分子馬達之生物物理及生物化學特性Biophysics and Biochemistry of Biomolecular Motors. (NCKU’s Landmark

           Project Grant) (2007.07-2008.06) (2008.11-2009.10)

      6.  利用智慧型標定式奈米球體攜帶人造核酸暨藥物並發展微機電光學檢測系統以開創癌症治療之新平台Novel anti-

           cancer platform with integrated smart targeting nanospheres carrying artificial nuclease and drugs and advanced optical detection

           system. (NSC95-2120-M-006-) (2006.08-2009.07) (NSTPNN-AEP)(共同主持人)

      7.  奈米粒子及生化分子自組裝製作可控親疏水性介面晶片(NSC 96-2218-E-002-) (2007.11-2010.10)(共同主持人)

      8.  使用奈米金粒子之多目標光熱治療與光聲影像技術(2007.01-2009.12)(NHRI-PPG )(共同主持人)

      9.  醫用最低侵入式非線性光學顯微術 (2007.01-2009.12) (NHRI-IRG ) (2010.01-2010.12) (NHRI-OIRG ) (共同主持人)

      10.  南台灣奈米科技核心設施服務計畫 (NSC 97-2120-M-006) (2006.08-2009.07) (NSTPNN-CFP) )(共同主持人)

      11.  生物組織之機械物理性質探討：奈米力學性質檢測及理論模式建立Investigation on Mechanical Properties of Tissue

             Biomaterials: Nanomechanical Property. (NSC 96-2221-E-194) (2007.08-2011.07) (共同主持人)

      12.  二甲基甲醯胺暴露引起之粒線體膜電位變化與去氧核糖核酸損害(2007.08-2008.07) (共同主持人)

      13.  肌動素調節蛋白質(Gelsolin)在胃癌侵襲過程的表現和上皮生長因子受器信息傳導途徑之相關性 Expression of

             Gelsolin during invasiveness of gastric adenocarcinoma and its correlation with EGFR signal pathway (NSC 96-2314-B-006)

             (2007.08-2010.07) (共同主持人)

      14.  新型牙科汞齊合金之開發 (NSC97-2622-E-006) (2006.06-2008.05) (共同主持人)

      15.  磁性奈米粒子在癌症治療之策略研發及其對癌細胞粒線體之作用機制 (NSC94-2314-B-006) (2005.08-2007.07)

      16.  台灣2025年工程與應用科學研究之預期與探討 (NSC95-2217-E-002-004) (2006.06-2007.07) (共同主持人)

      17.  南台灣奈米科技研究中心核心設施建置計畫(3/3) (NSC94-2120-M-006) (2005.08-2008.01) (NSTPNN-CFP) (共同

             主持人)

      18.  利用創新磁性奈米粒子作為基因轉殖及基因治療策略體內、外效應研究 (NSC92-2120-M-006) (2003.08-2006.07)

             (NSTPNN-AEP) (共同主持人)

      19.  奈米生物電子元件-生物分子的檢測 (NSC94-2120-M-001-005) (2005.08-2006.07) (NSTPNN-AEP) (共同主持人)

       20.  新型Α"型鈦合金性質及做為生醫植入物之整體評估－α"型鈦合金植入物生物相容性評估及對骨組織的影

              響 (NSC94-2321-B-002) (2003.08-2006.07) (共同主持人)

      21.  gelsolin於正常人類口腔上皮及口腔癌細胞之運動、凋亡及分化所扮演的角色及分子機轉之探討 (NSC92-2314-B-

             006) (2003.08-2005.07)

      22.  檳榔相關口腔病變之組織分子銀行、臨床資料庫之整合建構Identification of molecular markers involved in the

             pathogenesis of betel quid-chewing related oral. (NSC89-2323-B-006 ) (2000.08-2003.07) (共同主持人)

      23.  以誘導表現系統、核酸脢及基因踢除鼠模型研究gelsolin在人類口腔癌變所扮演的角色及其機轉 (NSC91-2314-B-

             006-054) (2002.08-2003.07)

      24.  細胞骨架調控蛋白(GELSOLIN, ABP-280, RAC,及 RHO)在人類口腔上皮癌化過程所扮演的角色及其表現與臨床

             預後 (NSC89-2314-B-006-)(2000.08-2002.07)

  

A.曾指導學生畢業後就業與升學情形

          分醫所碩士生

                   魏采音－馬偕醫院淡水分院藥理暨免疫研究組助研究員

                   陳藝文－中國後中醫學系

                  周文彬－台大分醫所博士班

                  卲鈞義－中研院專任助理

                  吳亞娜－中研院物理所、成功大學國科會專任助理、

                                  2008 The University of Sydney International Scholarship (USydIS)

                                 澳洲雪梨大學Key Center全額獎學金博士生

            口醫所碩士生

                      施宣宇－國衛院專任助理

                      賴泓霖－成功大學基醫所博士班

                      張千蕙－中研院專任助理

                      陳逸臨－加拿大國家研究院IBS LAB研究助理

                      張佑民－台大醫院專任助理

                      蕭宇宏－台中榮民總醫院專任助理

                      丁安安－成功大學專任助理

                      邱莉芳－成功大學專任助理

               基醫所博士生

                      吳炳慶－成功大學博士後研究員

B. 寒暑期研究生

                 林冠宇－(高雄醫學大學生物系)

                 洪曼珊－(成功大學醫學系)

                 賴妍君－(成功大學生物系) 分醫所碩士班畢

                 劉韋新－(成功大學醫技系)

                 林俊維－(成功大學醫技系)

                 劉友臻－(成功大學醫學系)

                 陳逸臨－(中興大學生命科學系)口醫所碩士班基礎組

                 劉仁傑－(成功大學醫技系) 成功大學醫技所碩士班

                 楊雨桑－清華大學材料科學工程學系

                 夏聖博－清華大學材料科學工程學系

                 楊捷羽－高雄醫學大學香妝品學系

                 Nirma Bustamante－Texas A&M University, Biology, USA (2005/06~08)

                 Priscilla Tsai (蔡恩慈)－Oberlin University, Ohio, USA(2006/01~02, 2006/06~08, 2007/07~08, 2008/01~02)

                 Omair Khan - Southern Methodist University, USA (2006/06~08)

                 Ida Hsin (辛尚穗)- Columbia University of New York, USA (2006/06~08)

                Thomas Vladimir Yves – City University of New York, USA (2007/06~08)

                Joe Liu (劉育成) –University of Sydney, Australia (2007/06~08)

                Johnny Chia-Hao Chiang (姜俊豪）- Texas A&M University, USA (2008/06~08)

                Andy Yen-An Chen (陳彥安) – University of Simon Fraser, Canada (2009/06~08)

                加拿大英屬哥倫比亞大學互動藝術與科技學院

C.目前實驗室成員

          博士後研究員

                吳炳慶

        基醫所博士生

                蔡宗霖

               王佩文

        口醫所碩士生

               碩二：黃琡勻

               碩一：李宗儒、王偉皇

        專任助理

               謝孟倫(行政助理)

               李映瑩

               呂秋君

               丁安安

               邱莉芳

              楊理行

              楊子嫻

D.學生之特殊榮譽

      1.  民國九十二年度國科會大專學生研究創作獎(賴妍君)

      2.  2005年第十一屆化學感測科技研討會口頭壁報論文競賽第三名,中華台灣化學感測器科技學會(黃佩瑜、邵鈞義)

      3.  2005年成大－中山微奈米科技聯合成果發表會暨南台灣微奈米研究成果海報展 (94/06/24)傑出獎(黃佩瑜、邵鈞義)

      4.  2005年成大－中山微奈米科技聯合成果發表會暨南台灣微奈米研究成果海報展 (94/06/24)特優獎(吳亞娜，分醫所)

      5.  2005年成大－中山微奈米科技聯合成果發表會暨南台灣微奈米研究成果海報展 (94/06/24)佳作獎(張千蕙，口醫所)

      6.  2006年成大醫學院研究生研究論文競賽第三組優勝(陳佳君，環醫所)

      7.  2006年IIAS暨南台灣微奈米研究成果海報展 (95/12/)生醫組佳作獎(吳炳慶，基醫所)

      8.  2006年84th General Session & Exhibition of the IADR (International Association for Dental Research), Brisbane, Australia, 2006 Jun-

           Jul. Frechette Competition finalist(張欣如)

      9.  2007年2007 International Conference on Bionano Sciences ( 2007-ICONBS), Taipei, Taiwan, 2007 Dec. Poster Presentation Award

           (蔡宗霖，基醫所)

      10.  2008 年成功大學醫學院Meritorious Research Award (吳炳慶，基醫所)

      11.  2008年IIAS暨NSC-NSF SBE&S Workshop論文海報競賽第一名(蔡宗霖，基醫所)

      12.  2008年IIAS暨NSC-NSF SBE&S Workshop論文海報競賽第二名(吳亞娜)

      13.  2008年86th General Session & Exhibition of the IADR (International Association for Dental Research), Toronto, Canada, 2008 Jul.  

             2008 IADR Diagnostic Sciences Group Student Award (陳逸臨，口醫所)

      14.  2008 The University of Sydney International Scholarship (USydIS) (吳亞娜)

      15.  2009年98學年度清華大學材料科學工程學系大學部研究論文競賽優等獎(楊雨桑，暑期生)

      16.  2009年98學年度清華大學材料科學工程學系大學部研究論文競賽佳作獎(夏聖博，暑期生)
　
　

A.主辦及參與國際會議

      1.  2009 MRS Fall Meeting, Boston, MA, USA, 2009 Nov-Dec.

      2.  BIT’s 2nd Annual Congress and Expo of Molecular Diagnostics                

           (CEMD-2009)－ New Leadership of Personalized Medicine, Beijing, China, 2009 Nov. (Invited speaker)

      3.  2009 Taiwan Nano, Taipei, Taiwan, 2009 Oct. ( Invited speaker)

      4.  2009 International Workshop on Nano Biomedicine, National Cheng Kung University, Tainan, Taiwan, 2009 Aug. (In charge)

      5.  The 11th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, 2009 Aug. ( Invited speaker)

      6.  The 7th Cross-Strait Workshop on Nanoscale Science and Technology, Guiyang, China, 2009 July. ( Invited speaker)

      7.  Second World Congress of the International Academy of Oral Oncology (IAOO), Toronto, Canada, 2009 July.

      8.  First World Congress of International Academy of Nanomedicine (IANM), Sanya, China, 2009 June. ( Invited speaker)

      9.  2009 NSTI Nanotechnology Conference and Trade Show, Houston, Texas, USA, 2009 May.

      10.  87th General Session & Exhibition of the IADR (International Association for Dental Research), Miami, USA, 2009 Apr.

      11. Taiwan (NCKU)-New Zealand Symposium on Nanotechnologies for Bio-imaging, Sensing, and Diagnosis. National Cheng Kung  

            University, Tainan, Taiwan, 2008 Nov. ( Invited speaker)

      12.  7th International Symposium on Nano-Biomedical Engineering. National Cheng Kung University, Tainan, Taiwan, 2008 Oct. ( Invited

             speaker)

      13.  Simultaneous Intravascular and Extravascular Targeting. 2008 World Molecular Imaging Congress. Nice, France, 2008 Sep. ( Invited

             speaker)

      14.  IEEE Nano 2008—8th International Conference in Nanotechnology. Arlington, Tx, USA, 2008 Aug.

      15.  86th General Session & Exhibition of the IADR (International Association for Dental Research), Toronto, Canada, 2008 Jul.

      16.  2008 Emerging Information and Technology Conference (EITC 2008). National Cheng Kung University, Tainan, Taiwan, 2008 Jun.(  

             Session Chair)

      17.  MR Molecular Imaging Symposium--From Bench to Bed. National Taiwan University Hospital, Taipei, Taiwan,2008 Jun. ( Invited

             speaker)

      18.  Partnership for International Research, Innovation and Development, University of Ottawa-Taiwan International Workshop on

             Nanotechnology. Ottawa, Canada, 2008 Mar. ( Invited speaker)

      19.  The Institute of Innovations and Advanced Studies (IIAS) / NSC-NSF SBE&S Workshop, NSKU, Tainan, Taiwan, 2008 Feb.

            (Secretary General)

      20.  2007 International Conference on Bionano Sciences ( 2007-ICONBS) 2007 Dec. ( Invited speaker)

      21.  台日雙邊奈米前瞻研究與教育研討會. Tainan, Taiwan, 2007 Dec. ( Invited speaker)

      22.  Canada-Taiwan Joint Workshop on Emerging Photonic Applications in Medicine, Taipei, Taiwan, 2007 Nov. ( Invited speaker)

      23.  The Seventh Annual Emerging Information Technology Conference (EITC-2007), Princeton, USA, 2007 Aug. ( Invited speaker)

      24.  The 7th IEEE International Conference on Nanotechnology (IEEE-NANO 2007 Technical Digest), Hong Kong, China, 2007 Aug. (  

             Invited speaker)

      25.  Engineering Conference International 2007 (ECI 2007) - Nanoscience and Nanotechnology for Biological/Biomedical/Chemical

             Sensing, Hong Kong, China, 2007 Jun. ( Invited speaker)

      26.  The First World Congress of the International Academy of Oral Oncology (IAOO), Amsterdam, Netherlands, 2007 May.

      27.  85th General Session & Exhibition of the IADR (International Association for Dental Research), New Orleans, USA, 2007 Mar.

      28.  The 5th Cross-Strait Workshop on Nanoscale Science and Technology, Hong Kong, China, 2006 Dec. ( Invited speaker)

      29.  The Institute of Innovations and Advanced Studies (IIAS), Taiwan, 2006 Dec. (Secretary General)

      30.  The MRS 2006 Fall Meeting-Session D2: Nanoparticles, Boston, MA, USA, 2006 Nov. ( Invited speaker)

      31.  台日雙邊奈米前瞻研究與教育研討會. Tokyo, Japan, 2006 Nov. ( Invited speaker)

      32.  Taiwan Nano-X 2006 台灣奈米國際週-亞洲奈米論壇-奈米人才培育研討會. Taipei, Taiwan, 2006 Sep. ( Invited speaker)

      33.  Invited Speaker－第21屆近代工程技術討論會（METS 2006）Taipei, Taiwan, 2006 Sep. ( Invited speaker)

      34.  The Sixth Annual Emerging Information Technology Conference (EITC-2006), Dallas, USA, 2006 Aug.( Invited Speaker & Session

             Chair)

      35.  84th General Session & Exhibition of the IADR (International Association for Dental Research), Brisbane, Australia, 2006 Jun-Jul.

             (Session Chair & Speaker)

      36.  Symposium W: Education in Materials Science and Engineering. The E-MRS 2006 Spring Meeting (E-MRS - IUMRS - ICEM 06),

             Nice (France), 2006, May-Jun. ( Invited speaker)

      37.  1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Zhuhai, China, 2006 Jan. ( Invited Speaker &

             Session Chair)

      38.  International Conference on Mitochondria and Life 2005--The 3rd Conference of the Asian Society for Mitochondrial Research and

             Medicine (ASMRM) and The 5th Conference of the Society of Mitochondrial Research and Medicine in Japan (J-mit), Tokyo, Japan,

             2005 Dec. ( Invited speaker)

      39.  2005 Nano Bioengineering International Symposium-- Quantum Dots for Live Cells, in vivo Imaging, and Diagnostics, Chung Yuan

             Christian University, Taiwan, 2005 Dec. ( Invited speaker)

      40.  The 4th Cross-Strait Workshop on Nanoscale Science and Technology, Lijiang, Yunnan, China, 2005 Aug. ( Invited speaker)

      41.  NSC-NRC-ITRI Trilateral Workshop on Nanoscience and Nanotechnology, National Science Council, National Research Council  

             Canada, Industrial Technology Research Institute, National Nanoscience and Nanotechnology Program Office, Canadian Trade Office

             in Taipei, Taipei, Taiwan, 2005 Jun. ( Invited speaker)

      42.  2003 International workshop on NanoBiotechnology, Industrial Technology Research Institute, Hsin-Chu, Taiwan, 2003 Mar. (

             Invited speaker)

      43.  The first scientific meeting of Asian Society for Mitochondrial Research and Medicine, Seoul, Korea, 2003 Feb. ( Invited speaker)

B.  教學與研究國際交流

      1.  受邀至國外大學及學術機構演講次數：10

      2.  至國外學術機構訪問次數：27

      3.  指導之學生至國外學術機構訪問人次：7

      4.  指導之學生至國外大學選讀人次：3

      5.  邀請國外教師至本單位訪問人次：26  

      6.  邀請國外學生至本單位訪問人次：12

      7.  與國外教師共同主持研究計畫人次：16