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廖寶琦 教授

職稱

教授

電話

+886-6-235-3535 ext. 5566

傳真

+886-6-2743748

電子信箱

liaopc@mail.ncku.edu.tw

實驗室

蛋白質體研究核心實驗室、環境微量毒物研究分析實驗室

開授課程

上學期

下學期

學歷

·         密西根州立大學  化學系博士    1990 / 08 至 1995 / 03

·         國立清華大學    化工所碩士    1986 / 09 至 1988 / 06

·         國立清華大學    化學系學士    1982 / 09 至 1986 / 06

經歷

·         國立成功大學      醫學院環境醫學研究所    教授      2007 / 01 迄今

·         國立成功大學      醫學院環境醫學研究所   副教授     2002 / 08 至 2007 / 01

·         國立成功大學      醫學院環境醫學研究所  助理教授    1997 / 08 至 2002 / 08

·         密西根州立大學          生化系           研究員     1995 / 04 至 1997 / 07

專長及研究領域

·         儀器分析

·         質譜分析技術

·         蛋白質體學

·         環境醫學

榮譽及獎勵 (至少五年內)
  • 　

專利 (至少五年內)

1. 廖寶琦、陳邦維、李國賓、林中源、陳淑慧、宋旺洲，專利名稱：使用微流體模組之樣品分析系統，中華民國專利證書發明第 I 247891號，專利權期間：2006年1月21日至2021年9月27日止，已核准。

2. 李國賓、廖寶琦、林中源、陳淑慧，專利名稱：晶片式微型噴嘴及其製造方法，中華民國發明專利證書發明第163294號，專利期間：2002年8月21日至2021年11月4日，已核准。

3. 廖寶琦、林隆晟、李建明、石東生，專利名稱：用於檢測人體有機毒物暴露量之自動化質譜分析系統，中華民國發明專利證書發明第180227號，專利期間：2003年6月1日至2022年8月26日，已核准。

4. 陳淑慧、宋旺洲、廖寶琦、李國賓，專利名稱：整合型微流體電噴灑晶片系統及其分析方法，中華民國發明專利證書發明第195810號，專利期間：2004年2月1日至2023年4月13日，已核准。

著作 (至少五年內)

A.      學術期刊發表論文 Journal Publication(s)：

1.   Tyan, Y.-C., Guo, H.-R., Liu, C.-Y., Liao, P.-C.* (2006) Proteomic profiling of human urinary proteome using nano-high performance liquid chromatography / electrospray ionization tandem mass spectrometry. Analytica Chimica Acta (in press). [SCI2004, Impact Factor = 2.588, Ranking: Chemistry Analytical, 12/70, 17.14%] [SCI2005, Impact Factor = 2.760, Ranking: Chemistry Analytical, 11/70, 15.71%]

2.   Hsu, J.-F., Guo, Y.-L., Liu, C.-H., Hu, S.-C., Wang, J.-N., Liao, P.-C.* (2006) A comparison of PCDD/PCDFs exposure in infants via formula milk or breast milk feeding. Chemosphere (in press). [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%][SCI2005, Impact Factor = 2.297, Ranking: Environmental Sciences, 21/140, 15.00%]

3.   Lee, C.-C., Guo, Y.-L., Kuei, C.-H., Chang H.-Y., Hsu, J.-F., Wang S.T., Liao, P.-C.* (2006) Human PCDD/PCDF levels near a pentachlorophenol contamination site in Tainan, Taiwan. Chemosphere 65, 436-448. [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%][SCI2005, Impact Factor = 2.297, Ranking: Environmental Sciences, 21/140, 15.00%]

4.   Chen, J.-W., Wang, S.-L., Yu, H.-Y., Liao, P.-C., Lee, C.-C.* (2006) Body burden of dioxins and dioxin-like polychlorinated biphenyls in pregnant women residing in a contaminated area. Chemosphere 65, 1667-1677. [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%]

5.   Lee, C.-C., Lin, W.-T., Liao, P.-C., Su, H.-J., Chen, H.-L.* (2006) High average daily intake of PCDD/Fs and serum levels in residents living near a deserted factory producing pentachlorophenol (PCP) in Taiwan: Influence of contaminated fish consumption. Environmental Pollution 141, 381-386. [SCI2004, Impact Factor = 2.205, Ranking: Environmental Sciences, 15/134, 11.19%]

6.   Lee, Y.-S., Chen, P.-W., Tsai, P.-J., Su, S.-H., Liao, P.-C.* (2006) Proteomics analysis revealed changes in rat bronchoalveolar lavage fluid proteins associated with oil mist exposure. Proteomics 6, 2236-2260. [SCI2004, Impact Factor = 5.483, Ranking: Biochemical Research Methods, 5/51, 9.80%]

7.   Lin, L.-C., Chiung, Y.-M., Shih, C.-F., Shih, T.-S., Liao, P.-C.* (2006) Validation of an online dual-loop cleanup device with an electrospray ionization tandem mass spectrometry-based system for simultaneous quantitative analysis of urinary benzene exposure biomarkers trans, trans-muconic acid and S-phenylmercapturic acid. Analytica Chimica Acta 555, 34-40. [SCI2004, Impact Factor = 2.588, Ranking: Chemistry Analytical, 12/70, 17.14%]

8.   Chen, H.-L., Su, H.-J., Guo, Y.-L., Liao, P.-C., Hung, C.-F., Lee, C.-C.* (2006) Biochemistry examinations and health disorder evaluation of Taiwanese living near incinerators and with low serum PCDD/Fs levels. Science of the total environment 366, 538-548. [SCI2004, Impact Factor = 1.925, Ranking: Environmental Sciences, 24/134, 17.91%]

9.   Chen, H.-L., Su, H.-J., Wang, Y.-J., Guo, Y.-L., Liao, P.-C., Lee, C.-C.* (2006) Interactive effects between CYP1A1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile. Journal of toxicology and environmental health 69(4), 269-281. [SCI2004, Impact Factor = 1.548, Ranking: Environmental Sciences, 37/134, 27.61%]

10. Tyan, Y.-C., Wu, H.-Y., Lai, W. -W., Su, W. -C., Liao, P.-C.* (2005) Proteomic profiling of human pleural effusion using two-dimensional nano liquid chromatography tandem mass spectrometry. Journal of Proteome Research 4, 1274-1286. [SCI2004, Impact Factor = 6.917, Ranking: Biochemical Research Methods, 3/51, 5.88%]

11. Tyan, Y.-C., Jong, S.-B., Liao, J.-D., Liao, P.-C., Yang, M.-H., Liu, C.-Y., Klauser, R., Himmelhaus, M., Grunze, M.* (2005) Proteomic profiling of erythrocyte proteins by proteolytic digestion chip and identification using two-dimensional electrospray ionization tandem mass spectrometry. Journal of Proteome Research 4, 748-757. [SCI2004, Impact Factor = 6.917, Ranking: Biochemical Research Methods, 3/51, 5.88%]

12. Hung, J.-J., Wu, C.-Y., Liao, P.-C., Chang, W.-C.* (2005) Hsp90 alpha recruited by Sp1 is important for transcription of 12(S)-Lipoxygenase in A431 cells. Journal of Biological Chemistry 280, 36283-36292. [SCI2004, Impact Factor = 6.355, Ranking: Biochemistry & Molecular Biology, 31/261, 11.88% ]

13. Tyan, Y.-C., Wu., H.-Y., Su, W.-C., Chen, P.-W., Liao, P.-C.* (2005) Proteomics analysis of human pleural effusion. Proteomics 5, 1062-1074. [SCI2004, Impact Factor = 5.483, Ranking: Biochemical Research Methods, 5/51, 9.80%]

14. Liao, P.-C., Kuo, Y.-M., Hsu, H.-C., Cherng, C.-G., Yu, L.* (2005) Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicity. Journal of Neurochemistry 95, 160-168. [SCI2004, Impact Factor = 4.824, Ranking: Neurosciences, 24/198, 12.12%]

15. Hsu, J.-F., Guo, Y.-L., Yang, S.-Y., Liao, P.-C.* (2005) Congener profiles of PCBs and PCDD/Fs in Yucheng victims fifteen years after exposure to toxic rice-bran oils and their implications for epidemiologic studies. Chemosphere 61, 1231-1243. [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%]

16. Lin, L.-J., Liao, P.-C., Yang, H.-H., and Tzen, J. T.-C.* (2005) Determination and analyses of the N-termini of oil-body proteins, steroleosin, caleosin and oleosin. Plant Physiology and Biochemistry 43, 770-776. [SCI2004, Impact Factor = 1.414, Ranking: Plant Sciences, 49/138, 35.51%]

17. Lee, C.-C., Chen, H.-L., Su, H.-J., Guo, Y.-L., Liao, P.-C.* (2005) Evaluation of PCDD/Fs patterns emitted from incinerator via direct ambient sampling and indirect serum levels assessment of Taiwanese. Chemosphere 59, 1465-1474. [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%]

18. Lin, Y.-S., Lin, C.-F., Fang, Y.-T., Kuo, Y.-M., Liao, P.-C., Yeh, T.-M., Hwa, K.-Y., Shieh, C.-C.-K., Yen, J.-H., Wang, H.-J., Su, I.-J., Lei, H.-Y.* (2005) Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cell and causes cytotoxicity. Clinical and Experimental Immunology. 141, 500-508. [SCI2004, Impact Factor = 2.518, Ranking: Immunology, 46/111, 41.44%]

19. Chen, H.-L., Liao, P.-C., Su, H.-J., Guo, Y.-L., Chen, C.-H., Lee, C.-C.* (2005) Profile of PCDD/F levels in serum of general Taiwanese between different gender, age and smoking status. Science of the Total Environment 337, 31-43. [SCI2004, Impact Factor = 1.925, Ranking: Environment Sciences, 24/134, 17.91%]

20. Liu, Y.-H., Huang, P.-C., Liao, P.-C., Shih, T.-S., Yang, H.-Y., Lee, C.-C.* (2005) Exposure assessment of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) for workers of secondary aluminum smelting plants. Journal of Occupational Safety and Health 13, 12-22.

21. Tyan, Y.-C., Liao, J.-D., Jong, S.-B., Liao, P.-C., Yang, M.-H., Chang, Y.-W., Klauser R, Himmelhaus M, Grunze M.* (2005) Characterization of trypsin immobilized on the functionable alkylthiolate self-assembled monolayers: a preliminary application for trypsin digestion chip on protein identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of materials science. Materials in medicine 16(2),  135-142. [SCI2004, Impact Factor = 0.864, Ranking: Materials science, multidisciplinary, 82/177, 46.33%]

22. Hsu, J.-F., Lee, C.-C., Guo, Y.-L., Kuei, C.-H., Chang, H.-Y., Liao, P.-C. (2005) Human dioxin levels near a pentachlorophenol contamination site in Tainan, Taiwan. Organohalogen Compounds. 75.

23. Huang, P.-C., Shih, T.-S., Hsueh, C.-Y., Lin, Y.-C., Liao, P.-C., Lee, C.-C.* (2004) Exposure assessment of polychlorinated dibezo-p-dioxins and dibenzofurans (PCDD/Fs) for workers of secondary ferrous metal smelting refining plant –electric arc furnace. Journal of Occupational Safety and Health 12, 301-314.

24. Lin, L.-C., Shih, J.-F., Shih, T.-S., Li, Y.-J., Liao, P.-C.* (2004) An ESI-MS/MS-based system with an online dual-loop cleanup device for simultaneous quantitation of urinary benzene exposure biomarkers trans,trans-muconic acid and S-phenylmercapturic acid. Rapid Communications in Mass Spectrometry 18, 2743-2752. [SCI2004, Impact Factor = 2.750, Ranking: Chemistry, Analytical, 10/70, 14.29%]

25. Wu, C.-W., Liao, P.-C., Yu, Y., Wang, S.-T., Chen, S.-T., Wu, C.-M., Kuo, Y.-M.* (2004) Hemoglobin promotes Aβ oligomer formation and localizes in neurons and amyloid deposits. Neurobiology of Disease 17, 367-377. [SCI2004, Impact Factor = 4.389, Ranking: Neurosciences, 32/198, 16.16%]

26. Tyan, Y.-C., Liao, J.-D., Jong, S.-B., Liao, P.-C., Yang, M.-H., Chang, Y.-W., Klauser, R., Himmelhaus, M., Grunze, M.* (2004) Proteomic profiling of platelet proteins by trypsin immobilized self-assembled monolayers digestion chip and protein identification using electrospray ionization tandem mass spectrometry. Journal of Biomedical Materials Research 71A, 90-97. [SCI2004, Impact Factor = 3.652, Ranking: Engineering, Biomedical, 4/42, 9.52%]

27. Lin, L.-C., Tyan, Y.-C., Shih, T.-S., Chang, Y.-C., Liao, P.-C.* (2004) Development and validation of an isotope-dilution electrospray ionization tandem mass spectrometry method with an on-line sample clean-up device for the quantitative analysis of benzene exposure biomarker SPMA in human urine. Rapid Communications in Mass Spectrometry 18, 1310-1316. [SCI2004, Impact Factor = 2.750, Ranking: Chemistry, Analytical, 10/70, 14.29%]

28. Chen, H.-L., Su, H.-J., Liao, P.-C., Chen, C.-H., Lee, C.-C.* (2004) Serum PCDD/F concentration distribution in residents living in the vicinity of an incinerator and its association with predicted ambient dioxin exposure. Chemosphere 54, 1421-1429. [SCI2004, Impact Factor = 2.359, Ranking: Environmental Sciences, 12/134, 8.96%]

29. Chen, H.-L., Su, H.-J., Liao, P.-C., Guo, Y.-L., Lee, C.-C., (2004) Patterns of Serum PCDD/Fs Affected by Vegetarian Habit and Consumption of Local Food of Residents Living Near Incinerator. Organohalogen Compounds. 70.

30.Sung, W.-C., Huang, S.-Y., Liao, P.-C., Lee, G.-B., Li, C.-W., Chen, S.-H.* (2003) Poly(dimethylsiloxane)-based microfluidic device with electrospray ionization-mass spectrometry interface for protein identification Electrophoresis 24, 3648-3654. [SCI2004, Impact Factor = 3.743, Ranking: Chemistry, Analytical, 6/70, 8.57%]

31. 廖寶琦，(2003) 質譜分析技術與蛋白質體學研究的興起。CHEMISTRY 第六十一卷 第二期，285-290。

32.Wu, C.-W., Liao, P.-C., Lin, C., Kuo, C.-J., Chen, S.-T., Chen, H.-I., Kuo, Y.-M.* (2003) Brain region-dependent increase in b-amyloid and apolipoprotein E levels in hyperchlolesterolemic rabbits. Journal of Neural Transmission 110, 641-649. [SCI2004, Impact Factor = 2.628, Ranking: Clinical Neurology, 33/140, 23.57%]

33.Chang, Y.-C., Li, C.-M., Li, L.-A., Jong, S.-B., Liao, P.-C., Chang, L.-W.* (2003) Quantitative measurement of male steroid hormones using automated on-line solid phase extraction-liquid chromatography/tandem mass spectrometry and comparison with radioimmunoassay. The Analyst 128, 363-368. [SCI2004, Impact Factor = 2.783, Ranking: Chemistry, Analytical, 9/70, 12.86%]

34. Kuo, Y.-M., Liao, P.-C., Lin, C., Wu, C.-W., Huang, H.-M., Lin, C.-C., Chuo, L.-J.* (2003) Lack of association between interleukin-1alpha polymorphism and Alzheimer disease or vascular dementia. Alzheimer Disease & Associated Disorders 17, 94-97. [SCI2004, Impact Factor = 1.748, Ranking: Pathology, 23/65, 35.38%]

35. Liao, P.-C., Kuo, Y.-M., Chang, Y.-C., Lin, C., Cherng, C.-F. G., Yu, L.* (2003) Striatal formation of 6-hydroxydopamine in mice treated with pargyline, pyrogallol and methamphetamine. Journal of Neural Transmission 110, 487-494. [SCI2004, Impact Factor = 2.628, Ranking: Clinical Neurology, 33/140, 23.57%]

36. Chen, H.-L., Lee, C.-C., Liao, P.-C., Guo, Y.-L., Chen, C.-H., Su, H.-J.* (2003) Associations between dietary intake and serum polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) levels in Taiwanese. Environmental Research 91,172-178. [SCI2004, Impact Factor = 1.793, Ranking: Environmental Sciences, 28/134, 20.90%]

37. Chen, H.-L., Lee, C.-C., Su, H.-J., Liao, P.-C., Guo, Y.-L., Hung, C.-F., (2003) E2, Testosterone, and Thyroid Related Function and serum PCDD/Fs levels in general populations. Organohalogen Compounds, 65: 230-233.

38. Chiou, C.-H., Lee, G.-B., Hsu, H.-T., Chen, P.-W., Liao, P.-C.* (2002) Micro devices integrated with microchannels and electrospray nozzles using PDMS casting techniques. Sensors and Actuators B: Chemical 86, 280-286. [SCI2004, Impact Factor = 2.083, Ranking: Instruments & Instrumentation, 2/48, 4.17%]

39. Chen, H.-L., Lee, C.-C., Liao, P.-C., Guo, Y.-L., Chen, C.-H., Su, H.-J.* (2002) Associations between dietary intake and PCDD/Fs levels in serum of Taiwanese. Organohalogen Compounds 55, 303-306.

40. Liao, P.-C.*, Liu, C.-H., Lee, C.-C., Guo, Y.-L. (2002) The PCDD/Fs levels in breast milk samples collected in Tainan city of southern Taiwan. Organohalogen Compounds 58, 305-308.

41. Chen, H.-L., Su, H.-J., Lee, C.-C., Liao, P.-C., Guo, Y.-L., (2002) Associations between dietary intake and PCDD/Fs levels in serum of Taiwanese. Organohalogen Compounds, 55:313-316.

42.Lee, C.-C., Chen, H.-L., Su, H.-J., Liao, P.-C., Guo, Y.-L., (2002) The distribution association between predicted ambient PCDD/Fs and Serum PCDD/Fs of residents from the vicinity of incinerator. Organohalogen Compounds, 58: 305-308

（以上為2002年8月1日之後所發表之學術論文著作）

43. Liao, P.-C.*, Li, C.-M., Lin, L.-C., Hung, C.-W., Shih, T.-S. (2002) An on-line automatic sample clean-up system for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid in human urine by electrospray ionization tandem mass spectrometry. Journal of Analytical Toxicology 26, 205-210. [SCI2004, Impact Factor = 1.722, Ranking: Chemistry, Analytical, 26/70, 37.14%]

44. Sung, W.-C., Lee, G.-B., Liao, P.-C., Chen, S.-H.* (2001) Electrophoresis microchips chemistry. The CHINESE CHEM. SOC.59, 423-428. (in Chinese)

45.Chen, S.-H., Sung, W.-C., Lee, G.-B., Lin, Z.-Y., Chen, P.-W., Liao, P.-C.* (2001) A disposable poly(methylmethacrylate)-based microfluidic module for protein identification by nano-electrospray ionization tandem mass spectrometry. Electrophoresis 22, 3972-3977. [SCI2004, Impact Factor = 3.743, Ranking: Chemistry, Analytical, 6/70, 8.57%]

46. Liao, P.-C.*, Li, C.-M., Hung, C.-W., Chen, S.-H. (2001) Quantitative detection of N7-(2-hydroxyethyl)guanine adducts in DNA using high performance liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry 36, 336-343. [SCI2004, Impact Factor = 3.056, Ranking: Spectroscopy, 7/42, 16.67%]

47.陳淑慧，林群哲，宋旺洲，林佾鴻，戴德禮，王蘭玉，陳邦維，張定宗，楊孔嘉，李國賓，黃冠瑞，廖寶琦，曾慶誠， (2001) 電泳晶片於DNA分析上的應用。微系統科技協會季刊 第五期，23-29。

48.鄒國鳳，李國賓，許惠婷，林中源，陳淑慧，廖寶琦，陳邦維，(2001) 微型蛋白質分析系統。微系統科技協會季刊 第五期，35-43。

49. 陳邦維，李國賓，林中源，陳淑慧，宋旺洲，廖寶琦，(2001) 微流體晶片連結質譜儀偵測在蛋白質分析上的應用。微系統科技協會季刊 第五期，44-51。

50. Yu, L.* and Liao, P.-C. (2000) Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice. Journal of Neural Transmission 107, 1139-1147. [SCI2004, Impact Factor = 2.628, Ranking: Clinical neurology, 33/140, 23.57%]

51.Yu, L.* and Liao, P.-C. (2000) Sexual differences and estrous cycle in methamphetamine-induced dopamine and serotonin depletions in the striatum of mice. Journal of Neural Transmission 107, 419-427. [SCI2004, Impact Factor = 2.628, Ranking: Clinical neurology, 33/140, 23.57%]

52. Harayama, H., Liao, P.-C., Gage, D., Miyake, M., Kato, S., Hammerstedt, R.* (2000) Biochemical characterization of sialoprotein anti-agglutinin purified from boar epididymal and seminal plasma. Molecular Reproduction and Development 55, 96-103. [SCI2004, Impact Factor = 2.331, Ranking: Reproductive Biology, 8/24, 33.33%]

53. Liao, P.-C.*, Kuei, C.-H., Chang, H.-Y., Guo, Y.-L. (2000) Background dioxin levels in the blood of residents in the vicinity of a municipal waste incinerator in southern Taiwan. Organohalogen Compounds 48, 79-82.

54. Voitenleitner, C., Rehfuess, C., Hilmes, M., Orear, L., Liao, P.-C., Gage, D.-A., Ott, R., Nasheuer, H.-P., Fanning, E.* (1999). Cell cycle-dependent regulation of human DNA polymerase alpha-primase activity by phosphorylation. Molecular and Cellular Biology 19, 646-56. [SCI2004, Impact Factor = 7.822, Ranking: Biochmistry and  Molecular Biology, 22/261, 8.43%]

55. Ransom, W.-D., Liao, P.-C., Gage, D.-A., Boss, W.-F.* (1998). Phosphoglycerylethanolamine posttranslational modification of plant eukaryotic elogation factor 1 alpha. Plant Physiology 117, 949-60. [SCI2004, Impact Factor = 5.881, Ranking: Plant Sciences, 7/138, 5.07%]

56. Liao, P.-C., Huang, Z.-H., Allison, J.* (1997). Charge remote fragmentation of peptides following attachment of a fixed positive charge: a matrix-assisted laser-desorption/ionization post-source decay study. Journal of the American Society for Mass Spectrometry 8, 501-9. [SCI2004, Impact Factor = 3.760, Ranking: Chemistry, Analytical, 5/70, 7.14%]

57.Kang, S., Liao, P.-C., Gage, D.-A., Esselman, W.-J.* (1997). Identification of in vivo phosphorylation sites of CD45 PTPase: CD45 PTPase activity correlates with phosphorylation of CD45 and cell growth density in 70Z/3.12 cells. Journal of Biological Chemistry 272, 11588-96. [SCI2004, Impact Factor = 6.355, Ranking: Biochmistry and Molecular Biology, 31/261, 11.88%]

58. Rathinasabapathi, B., Burnet, M., Russel, B.-L., Gage, D.-A., Liao, P.-C., Nye, G.-J., Scott, P., Golbeck, J.-H., Hanson, A.-D.* (1997). Choline monooxygenase, an usual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning. Proceedings of the National Academy of Sciences of the USA 94, 3454-8. [SCI]

59. Bachmann, M., Huber, J.-L., Liao, P.-C., Gage, D.-A., Huber, S.-C.* (1996). The inhibitor protein of phosphorylated nitrate reductase from spinach (spinacia oleracea) leaves Is a 14-3-3 protein. FEBS Letters 387, 127-31. [SCI2004, Impact Factor = 3.843, Ranking: Biophysiscs, 10/64, 15.63%]

60.Huber, S.-C.*, Huber, J.-L., Liao, P.-C., Gage, D.-A., McMichael, R- W., Jr., Chourey, P.-S., Hannah, L.-C., Koch, K. (1996). Phosphorylation of serine-15 of maize leaf sucrose synthase: occurrence in vivo and possible regulatory significance. Plant Physiology 112, 793-802. [SCI2004, Impact Factor = 5.881, Ranking: Plant Sciences, 7/138, 5.07%]

61. Liao, P.-C., and Allison, J.* (1995). Ionization processes in matrix-assisted laser desorption/ionization mass spectrometry: matrix-dependent formation of [M+H]+ vs. [M+Na]+ ions of small peptides and some mechanistic comments. Journal of Mass Spectrometry 30, 408-23. [SCI2004, Impact Factor = 3.056, Ranking: Spectroscopy, 7/42, 16.67%]

62. Liao, P.-C., and Allison, J.* (1995). Enhanced detection of peptides in matrix-assisted laser desorption/ionization mass spectrometry through the use of charge-localized derivatives. Journal of Mass Spectrometry 30, 511-12. [SCI2004, Impact Factor = 3.056, Ranking: Spectroscopy, 7/42, 16.67%]

63. Liao, P.-C., and Allison, J. *(1995). Dissecting matrix-assisted laser desorption/ionization mass spectra. Journal of Mass Spectrometry 30, 763-6. [SCI2004, Impact Factor = 3.056, Ranking: Spectroscopy, 7/42, 16.67%]

64. Liao, P.-C., Leykam, J., Andrews, P.-C., Gage, D.-A., Allison, J.* (1994). An approach to locate phosphorylation sites in a phosphoprotein: mass-mapping by combining specific enzymatic degradation with matrix-assisted laser desorption/ionization mass spectrometry. Analytical Biochemistry 219, 9-20. [SCI2004, Impact Factor = 2.370, Ranking: Chemistry, Analytical, 5/70, 7.14%]

65. Wang, Y.-K., Liao, P.-C., Allison, J., Gage, D.-A., Andrews, P.-C., Lubman, D.-M., Hanash, S.-M., Strahler, J.-R.* (1993). Phorbol 12-myristate 13-acetate-induced phosphorylation of Op 18 in Jurkat t cells: identification of phosphorylation sites by matrix-assisted laser desorption/ionization mass spectrometry. Journal of Biological Chemistry 268, 14269-77. [SCI2004, Impact Factor = 6.355, Ranking: Biochmistry and Molecular Biology, 31/261, 11.88%]

 

B. 其他學術著作 Other Publication(s)：

1. 廖寶琦、林隆晟（2002）致癌性化學物質苯的健康危害與暴露評估，國立成功大學校刊，第200期，9-10。

2.  Liao, P.-C. (1995, March). Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry: fundamental studies and its application in the analysis of phosphoproteins. Ph.D. dissertation, Michigan State University, East Lansing, Michigan, USA.

研究計畫 (至少五年內)

·         快速蛋白質分析之微流體晶片系統之研發-整合微流體晶片與微電灑離子化法質譜儀之微裝置供作蛋白質的快速鑑別   89.08.01~92.07.31

·         微電灑離子源之製作及微電灑離子化質譜法在蛋白質分析之應用   90.08.01~91.07.31

·         人體血液中戴奧辛背景值調查   90.01.01~92.12.31

·         1 , 3丁二烯血液血紅素結合物樣品分析   91.05.01~91.12.16

·         臺灣肺癌基因體研究及臨床應用：著重於女性肺腺癌－分項計畫五：肺腺癌之環境因子及基因體毒理研究－蛋白質與肺癌及環境因子互動關係   91.05.01~93.12.31

·         利用串式質譜儀發展一套自動化樣品淨化暨定量裝置來偵測尿液中的致癌毒性化學物質暴露指標   91.08.01~94.07.31

指導學生情況 (至少五年內)

A. 指導學生

·         90年論文

·         劉純湖  台南地區婦女乳汁中戴奧辛與多氯聯苯濃度之調查研究     

·         胡淑娟  台灣地區嬰兒配方奶粉中多氯戴奧辛、多氯夫喃及疑似戴奧辛之多氯聯苯濃度調查研究     

·         洪千雯  Hepa-1小鼠細胞蛋白質體如何受2,3,7,8－四氯戴奧辛影響    

·         89年論文

·         許菁芳  油症患者血液中多氯聯苯多氯戴奧辛多氯夫喃同源物濃度與肝功能異常之相關性研究    

·         李健明  發展一種液相層析儀方法用來偵測去氧核醣核酸中之氮7-12-脛基乙基鳥糞鹼加合物    

主辦及參與國際會議 (至少五年內)

 

教學與研究國際交流
  • 受聘至國外大學及學術機構講學次數：
  • 至國外學術機構訪問次數：
  • 指導之學生至國外學術機構訪問人次：
  • 指導之學生至國外大學選讀人次：
  • 邀請國外教師至本單位訪問人次：
  • 邀請國外學生至本單位訪問人次：
  • 與國外教師共同主持研究計畫人次：