Graduate Institute of Environmental and Occupational Health
Medical College, National Cheng Kung University

Huey-Jen Su   Professor

Course Name

 Research Methodology

Credits

 2

Period

Fall

Objects

 

Schedule

Date

Topic

 　

2002/9/17

Introduction

 　

The Anatomy and Physiology of Research

 　

2002/9/24

Conceiving the Research Question

 　

Literature Search

 　

2002/10/1

Choosing the Study Subjects: Specification

 　

Sampling

 　

2002/10/8

Planning the Measurements: Precision and Accuracy

　

Planning the Measurements: Questionnaires

 　

2002/10/15

Discussion I

 　
　

2002/10/22

Discussion I

 　
　

2002/10/29

Designing a New Study: Diagnostic Tests

　

Designing a New Study: Experiments

 　

2002/11/5

Designing a New Study: Cross-sectional

　

Designing a New Study: Case-control Studies

 　

2002/11/12

Designing a New Study: Cohort Studies

　

Enhancing Causal Inference in Observational Studies

 　

2002/11/19

Discussion II

 　
　

2002/11/26

Discussion II

 　
　

2002/12/3

Hypotheses and Underlying Principles

 　

Estimating Sample Size and Power

 　

2002/12/10

Biases of the Studies

 　

Using Secondary Data

 　

2002/12/17

Data Management and Analysis

 　

Implementing the Study: Pretesting, Quality Control, and Protocol Revisions

 　

Write up the research proposal

 　

2002/12/24

Final discussion and Review of Research proposal

　
　

2002/12/31

Final discussion and Review of Research proposal

　
　

　

References

 DESIGNING CLINICAL RESEARCH.  Eds.: Stephen B. Hulley et al, Lippincott, Williams & Wilkins, Philadelphia, 2001

Lecture type

 講義

Grade

1.       Presentation: Discussion I(5%); Discussion II(10%), Final Discussion(30%)

2.      Homework I(10%), Homework II(10%), Final report(30%)

3.      Participation(5%)

Others

 

 

科目名稱

 Environmental Health

學分數

 2

開課學期

 Fall

教學目標

 

教學大綱

9/20

Introduction to Environmental Health

9/27

Water Supply

10/04

Municipal Waste:treatment and disposal(I)

10/11

Municipal Waste:treatment and disposal(II)

10/18

Hazardous Waste

10/25

Ionizing Radiation

11/01

Global Environmental Issues(I)

11/08

Global Environmental Issues(II)

11/15

Mid-term Examination

11/22

Air Pollution: Sources

11/29

Air Pollution: Meteorology and Dispersion

12/06

Air Pollution: Effects

12/13

Indoor Air Pollution (I)

12/20

Indoor Air Pollution (II)

12/27

Environmental hormone and POPs

1/03

Risk Assessment and Management of Toxic Chemicals

1/10

Environmental Impact Assessment

1/17

Final Examination

　

參考教材

 

講授方式

 講義

成績考評

1.       期中考、期末考各佔40%。

2.       期末報告佔20%，報告題目於期中考前選定並交出，每篇報告至少須參考三篇2000年以後出版SCI文章，完整報告於1/10交出，逾期一天扣期末總分一分。

3.       報告格式：

—　標題

—　中英文摘要（五百字內）

—　前言（六百字內）

—　本文

—　結論

—　參考文獻（依文中出現先後順序編號並標註於文中）

備註

 

 

科目名稱

 Risk Assessment

學分數

 2

開課學期

 Fall

教學目標

 

教學大綱

9/20

Introduction to risk assessment

9/27

Hazards identification

10/04

Dose response assessment (I)

10/11

Dose response assessment (II)

10/18

Dose response assessment (III)

10/25

Exposure assessment (I)

11/01

Exposure assessment (II)

11/08

Exposure assessment (III)

11/15

Mid-term Examination

11/22

Risk characterization(I)

11/29

Risk characterization(II)

12/06

Risk characterization(III)

12/13

Assessment of ecological risk

12/20

Case study 1

12/27

Case study 2

1/03

Case study 3

1/10

Final presentation(I)

1/17

Final presentation(II)

　

參考教材

1. Risk Assessment in the Federal Goverment : Managing the process, NRC, USA, 1983.

2. The Risk Assessment Guidelines of1986, USEPA.

3. Guideline for Exposure Assessment Notice, USEPA, 1992

4. Toxicology and risk assessment - principles, methods, and applications, edited by Anna M. Fan and Louis W. Chang.

講授方式

Platform

成績考評

1.期中考佔50%。

2.口頭及書面報告佔25%，報告題目於期中考前選定並交出，完整報告於1/17交出，逾期一天扣期末總分三分。

備註

 

 

科目名稱

Introduction to Occupational and Environmental Medicine

學分數

2

開課學期

Fall

教學目標

 

教學大綱

9/16

Introduction to Occupational and Environmental

9/23

Occupational and Environmental Physical Hazards

9/30

Occupational Musculoskeletal Disorders

10/7

Pneumoconiosis and Other Occupational Lung Diseases

10/14

Biological Agents in Occupation & Environment

10/21

Environmental Health: International Perspectives

10/28

Occupational Skin Diseases

Ototoxicity, Noise, and Hearing Loss

11/04

Neuropsychological battery

11/18

Midterm Examination

11/25

Occupational & Environmental Health Surveillance

12/2

Chemical Hepatotoxicity and Occupational Liver Disease

12/9

Occupational and Environmental Cardiovascular Hazards and Diseases

Acute and Chronic Nephrotoxicity of Occupational and Environmental Hazards

12/16

Occupational and Environmental and Occupational Diseases

12/23

Susceptibility to Environmental Reproductive Hazards and Diseases

12/30

Mechanism and Identification of Environmental and Occupational Carcinogens

1/6

Occupational Trauma and Occupational Safety

1/13

Final Examination

　

參考教材

 郭育良等：職業病概論，第二版，華杏出版股份有限公司，2002

講授方式

 Platform

成績考評

 

備註

 

 

Course Name

 The critical events in the environmental and occupational health

Credits

 1

Period

  09/15/2002~01/16/2002

Objects

Many critical episodes and events with respect to environmental and occupational health affect the contemporary and the following eras substantially.  This course gives an insight of the happenings and the impacts of these events.

Schedule

Item

Date

Topic

Lecturer

1

9/16

Class Orientation

Chang HY

2

9/23

Close view on significant episodes regarding environmental and occupational health and their impact analysis

Chang HY

3

9/30

What is the Gulf War Syndrome and why it happened

Liu MY

4

10/7

The inimical heritages of industrial manufacturing process

Lee CC

5

10/21

What did we learn from the dioxin-polluted event in Belgium

Liao PC

6

11/11

Dolly :  Cloning experience and impact

Wang YR

7

11/18

Micro-organism’s fantastic world

Su HJ

8

12/2

Polybiphenyls, polyfurans, and polydioxin

Guo YL

9

12/16

Black foot disease and arsenic

Guo HR

10

12/23

Lead pollution and control

Cheng YW

　

References

 Assigned paper or textbook by class instructors

Lecture type

Lecture, two-way discussion, and paper critiques

Grade

 Grades will be based on course participation (30%), and the final report (70%)

Others

 

 

科目名稱

 Exposure Assessment & Epi Study

學分數

 2

開課學期

Fall

教學目標

 

教學大綱

日期

Topic

9/18

Introduction to Exposure Assessment & Epi Study

9/25

Exposure Characterization for Epi : Concepts & Methods

10/2

Measurement of Exposure

10/9

Issues of bio-aerosol measurement

10/16

Common bias in Epi study

10/23

Data management of exposure data in Epidemiology

10/30

Exposure Matrix: The applications and its perspective in Epi

11/6

Total Exposure Dose v.s. Health Outcomes

11/13

Reliability and validity assessment

11/20

Linking exposure with outcome

11/27

Dose-response assessment

12/4

Paper Critique -Practice

12/11

Paper Critique I

12/18

Paper Critique II

12/25

Paper Critique III

1/8

Final Presentation - I

1/15

Final Presentation - II

　

參考教材

 There is no assigned textbook for this course. However, the submitted journal articles will be requested to review before attending the course.

講授方式

 Platform

成績考評

1.      Course participation : 20 %

2.      The performance of critique writing 30 %

3.      Final Presentation : 50 %

備註

 

 

科目名稱

 Industrial Hygiene

學分數

 2

開課學期

Fall

教學目標

 

教學大綱

1.          Introduction to Industrial Hygiene

2.           Hazard Recognition: Particulates

3.           Hazard Recognition: Solvents

4.          Hazard Recognition: Radiation

5.          Hazard Recognition: Extreme Temperature

6.          Hazard Recognition: Biological Factors

7.          Hazard Recognition: Ergonomics

8.          Hazard Recognition: Noise

9.          Mid-term Examination

10.      Method of Evaluation: Gas and Vapor

11.      Method of Evaluation: Particulate

12.      Method of Evaluation: Biomarker and BEI

13.      Hazard Control: General Principles

14.      Hazard Control: Administrative and Engineering Control

15.      Journal Article Presentation

16.      Journal Article Presentation

17.      Final Examination

參考教材

 Fundamentals of Industrial Hygiene, 3rd Ed. National Safety Council, USA, 1988

講授方式

 Platform

成績考評

 A/O grades

備註

 

 

科目名稱

 Study Design and Research Methodology

學分數

 2

開課學期

 Spring

教學目標

 

教學大綱

DATE

COURSE TILE

2月17日

Anatomy and Physiology of a Study

Conceiving the Research Question

2月24日

Study Subjects (Inclusion, Sampling, Exclusion, selection bias)

Measurement (including measurement error and bias)

3月3日

Exposure Assessment

3月10日

Discussion (I): The Research Question, Significance, and Study Subjects(交第一次作業)

3月17日

Discussion (I): The Research Question, Significance, and Study Subjects

3月24日

Laboratory Experiment Design (I)

3月31日

Laboratory Experiment Design (II)

4月7日

Planning the Measurements: Questionnaires

4月14日

Designing a New Study: Diagnostic Tests

Designing a New Study: Clinical Trials

4月21日

Using Secondary Data

4月28日

Discussion (II): The Variables and Hypothesis Testing (交第二次作業)

5月5日

Discussion (II): The Variables and Hypothesis Testing     

5月12日

Enhancing Causal Inference in Observational Studies

Biases of the Studies

5月19日

Hypotheses and Underlying Principles

Estimating Sample Size and Power

5月26日

Confounding and Effect Modification

6月2日

Implementing the Study: Pretesting, Quality Control, and Protocol Revisions

Write up the research proposal

6月9日

Final discussion and Review of Research proposal

6月16日

Final discussion and Review of Research proposal

6月23日

繳交期末作業

　

參考教材

 DESIGNING CLINICAL RESEARCH.  Eds.: Stephen B. Hulley et al, Lippincott, Williams & Wilkins, Philadelphia, 2001

講授方式

 Platform

成績考評

1.      Presentation: Discussion I(5%); Discussion II(10%), Final Discussion(30%)

2.      Homework I(10%), Homework II(10%), Final report(30%)

3.      Participation(5%)

備註

 

 

科目名稱

 Environmental and Occupational Health

學分數

 2

開課學期

 Spring

教學目標

 

教學大綱

日期

課　　　目

2/18

Introduction to Environmental and Occupational Health

2/25

Chemical Hazards

3/04

Physical Hazards

3/11

Biological and other Hazards

3/18

Occupational medicine and Occupational Diseases

3/25

Environmental medicine and Human Health

4/01

Water Sanitation

4/08

Municipal Waste Management

4/15

Mid-term Examination

4/22

Air Pollution: Sources

4/29

Air Pollution: Impact

5/06

Global Environmental Issues

5/13

Indoor Environmental Quality

5/20

Vector Control

5/27

Food Sanitation

6/03

Environmental hormone and POPs

6/10

Environmental Impact Assessment

6/17

Final Examination

　

參考教材

 1.J. Glynn Henry and Gary W. Heinke, Environmental Science and Engineering, 1989, Prentice-Hall International Editions.

2.Barbara A. Plog, Fundamentals of Industrial Hygiene, 3rd. Edition, National Safety Council, Chicago, IL, 1988.

3.Jonathan M. Samet and John D. Spengler, Indoor Air Pollution, 1991, The Johns Hopkins University Press.

講授方式

Platform

成績考評

 

備註

 

 

科目名稱

Bological Mnitoring

學分數

 2

開課學期

 Spring

教學目標

 

教學大綱

2/19

Lecture: Introduction to biological monitoring

2/26

Lecture: An overview and guideline of biological monitoring

3/5

Lecture: Guiding principles for the use of biological markers in the assessment of human exposure to environmental factors

3/12

Lecture: Molecular biomarkers

3/19

Lecture: Toxicity tests relating biological monitoring

3/26

Mid-term Exam

4/9

Lecture: Biological monitoring in occupational and environmental medicine

4/16

Lecture: Validity criteria for the use of biological markers of exposure

4/23

Lecture: Biokinetics and stability aspects of biomarkers

4/30

Lecture: The biomarkers of exposure to biological materials

5/7

Lecture: Biological Exposure Indices in the world

5/14

Lecture: An example for the research in Biological monitoring

5/21

Final Exam

5/28

Critique - Internal dose/ Biological effective dose

6/11

Critique - Susceptibility markers/ Health effects

6/18

Final presentation

　

參考教材

1.       Mendelsohn ML, Peeters J, Normandy MJ, eds. Biomarkers and occupational health : Progress and perspectives. Joseph Henry Press., Washington, D.C., USA. 1995.

2.       Sheldon L, Umana M, Bursey J., et al., Biological monitoring techniques for human exposure to industrial chemicals. Noyes Publications. Park Ridge, NJ, USA. 1986.

3.       Huggett RJ, Kimerle RA, Mehrle PM, Bergman HL, eds. Biomarkers: Biochemical, physiological, and histological markers of anthropogenic stress. Lewis Publishers. Ann Arbor, MI, USA. 1989.

4.       American conference of governmental industrial hygienists (ACGIH). Documentation of the threshold limit values and biological exposure indices. ACGIH, Cincinnati, OH, USA. 1986.

講授方式

 Platform

成績考評

 Grades will be based on exam (40%), critique writing (20%), and final presentation and term report (40%) of the assigned topic. However, class participation will be reviewed as a basis to modify the final score.

備註

 

 

科目名稱

 腫瘤生物學

學分數

 2

開課學期

Spring

教學目標

 

教學大綱

 2/18

Introduction

2/25

Trumor suppressor gene

3/4

Oncogene

3/11

Cancer pathology

3/18

Angiogenesis

3/25

Metastasis

4/8

Metastasis

4/15

Virus and human cancer

4/22

HBV and hepatoma

4/29

Cancer immunology

5/6

Lung cancer

5/13

Bladder cancer

5/20

Hepatoma

5/27

Chemotherapy

6/3

Gene therapy

6/10

Discussions on Term report

　

參考教材

 

講授方式

 Platform

成績考評

　

備註

 

 

科目名稱

Special Topics in Environmental and Occupational Health

學分數

2

開課學期

 Spring

教學目標

 

教學大綱

This course is designed to enhance the capability of conducting scientific discussion in English for graduate students.  Two of the registered students in this course will be assigned to give a 15-minute summary presentation, and lead a 25-minute discussion afterwards.  The number of students is to be limited between 10-15.  There will probably be 2 presentations to give for every registered student in this course time.  Assigned student should identify the article to be discussed at least 1 week before the class, and e-mail to the surprising instructor and all participants.

參考教材

All SCI articles of 2000-2002.

講授方式

 Platform

成績考評

        Presence (10%)

        Class participation (15%)

        Writing of summary reports (40%)

        Final presentation (35%)

備註