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Huey-Lang Yang

Title
Director and Professor

Telephone

+886-6-275-7575 ext. 65601

Faxsmile

+886-6-2766505

email

hlyang@mail.ncku.edu.tw

 Address

1 University Road, Institute of Biotechnology,

National Cheng Kung University,

Tainan, Taiwan 70101

Teaching

First semester

Second semester

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Training
  • Ph.D(1972) , University of California at Davis, Major  Bacteriology
  • B.S & A (1966), national Taiwan University, Department of Agricultural Chemistry

Experiences
  • University professor, NCKU (2002- )
  • Director, Institute of biotechnology, NCKU (2000- )
  • Professor, Institute of Biotechnology 92000- )
  • Associate Director, Center of Biotechnology(2000- )
  • Research Fellow, Institute of BioAgricultural Sciences, Academia Sinica (1998- )
  • Adjunct professor, National Taiwan University (1994- )
  • Director, Division of Molecular Biology, Development Center for Biotechnology (1991-1997)
  • Visiting professor, National Yang-Ming University(1990-1991)
  • Managing Director of Research and Development, ENZO Diagnostics Inc., (1988-1990)
  • Director, Recombinant DNA / Microbiology, ENZO Biochem, Inc.(1984-1988)
  • Associate Director, Recombinant DNA, ENZO Biochem, Inc.(1982-1984)
  • Associate, Department of Genetics, The Public Health Research Institute in the City of New York (1980-1982)
  • Adjunct Assistant professor, New York University, School of Medicine (1980-1982)
  • Senior Research Associate, Department of Biological Sciences, Columbia University (1977-1980)
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專長及研究領域
  • Biotechnology
  • Vaccine
  • Diagnostics

 

 

Honor

  • Distinguish in Science and technology, Executive Yuan, 1992 
  • Member of editorial board of Asia-Pacific Journal of Molecular Biology and Biotechnology
  • Food Science and Agricultural Chemistry Journal: Editorial board 1999
  • Invited speaker: 3rd International Symposium of Fish Vaccinology, 2003

 

專利 (至少五年內)
  • 0124124: Methods and materials useful for the analysis and detection of genetic material ( Inventor : Yang, Kirtikar and Pergolizzi ).Publication date: 1984. 07.11 Country designated:11: AT, BE, CH, DE, Fr, GB, IT, LI, LU, NL, SE
  • 0133473: In Vivo labeling of polynucleotide sequuences ( Inventor: Stravrianopoulus, Yang and Kelker ). Publication date: 1985. 02.27 Country designated: 11: AT, BE, CH, DE, FR, GB, IT, LU, LI, NL, SE
  • 0294595: Polynucleotide composition and method for its production ( Inventor : Yang and Donegan ). Publication date: 1988. 12.14 Country designated: 13: AT, BE, CH, DE, ES, FR, GB, IT, LI, LU, NL, SE
  • 0237737: Nucleic acid probes specific for Neisseria gonorrhea and method for screening for a nucleic acid sequence specific for a genetically distinct group (Inventor: Lo and Yang ). 1987. 09. 23 Country designated: 9: BE, CH, DE, FR, GB, IT. LI, NL, SE
  • 0343424: Method for sample adherence to test substrate (Inventor: Yang, Todd and Jou ) . Publication date: 1989.11.29 Country designated: 4: DE, FR, GB, IT
  • 4900659: Nucleotide sequence composition and detection of Neisseria  gonorrheae and method for screening for a nucleotide sequence that is specific for a genetically distinct group (Inventor : Lo and Yang ) . 1990. 2. 13
  • 4987065: In vivo labeling of polynucleotide sequences (Inventor : Stravrianopoulus, Yang and Kelker ). 1991. 6. 22
  • 5024933: Method and kit for sample adherence to test substrate ( Inventor :     Yang, Todd nd Jou ). 1991. 6. 18
  • 1299073 : April 21, 1992 Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for genetically distinct group Inventor: Andrew Lo and Huey-Lang Yang
  • 1338856: Jan 21, 1997 In vivo labeling of polynucleotide seqeunce Inventor: N. Kelker, J. Stavrianopoulos, Huey-Lang Yang
  • 1,339,249: Aug. 12,1997 Method for sample adherence to test substrate Inventor : H-L. Jou, J. Todd and Huey-Lang Yang Yang
  • 1,340,100:Oct 27, 1998 Polynucleotide composition and method Inventor : J. Donegan and Huey-Lang Yang
  • 2607058   Feb 13, 1997 A method for in vitro labeling polynucleotide Stravrianopoulus, Yang and Kelker
  • 2540482  July 8, 1996 In vitro labeling of polynucleotide sequence Stravrianopoulus, Yang and Kelker
  • 081902 1996.10.17, The preparation of (ZEBRA) antigen
  • 080691 1996.10.01, The preparation of recombinant EB-DNA polymerase  and its application
  • 83108294,371671, The isolation and preparation of gE antigen of pseudo-rabbi virus and its application  (1999 )
  • The nucleotide sequence of the  gX-gP63-gp50-gI and Tkgene of PRV and their application (Pending)
  • Nucleotide sequences of Nervous Necrosis Virus and its application (US patent pending)
  • A fish oral vaccine method with bioencapsulation of recombinant bacterium (US patent pending)

 

Publication
A. Refereed Papers
  1. Han-Tso Lin, Han-You Lin, Huey-Lang Yang,( 2005) Studies of the Histology and Histochemical Enzyme-Staining Patterns of Major Immune Organs in Malabar Grouper (Epinephelus malabaricus, Bloch et Schneider), Journal of Fish Biology 66, 729-740. (PDF download)
  2. H.S. Kuo, Y-L Su, H-L. Yang, and T.Y. Chen, (2005) Identification of Chinese medicinal fungus Cordyceps sinensis by PCR-single stranded conformation polymorphism and phylogenetic relationshipJ. Agri. Food Chem. (PDF download)
  3. P.R. Rajan, John H-Y Lin, M-S. Ho and H-L. Yang, (2003) Simple and rapid detection of Photobacterium damselae subsp. piscida by a PCR technique and plating method Jour of Applied Microbiology ,(J. of Applied Microbiology 2003, 95, 1375-1380. (PDF download)
  4. Lopez C, J.P.R. Rajan, John Han-You Lin, Tsun-Yung Kuo & Huey-Lang Yang. (2002)Disease outbreak in seafarmed Cobia (Rachycentron canadum) associate with Vibrio spp., Photbacterium damselae ssp piscida, monogenean and mycosporean parasites Bulletin of the European Association of Fish pathologist 22 (3), 206-211.
  5. M.Y.Liu, Y.L.Chang, J.Ma, H.L.Yang, M.W.Hsu, C.J.Chen, J.Y.Chen, C.S.Yang。1997。 Evaluation of multiple antibodies to EB us as markers for detecting patients with nasopharyngeal carcinoma J. of Medical Virology 52:262-269 .
  6. Review：Huey-Lang Yang。1999。The application of new biotechnology for disease prevention in animal pp. 73-82 in “ Biotechnology in agriculture in Asia, Asian productivity Organization.
  7. J.W.Shiau, T.K. Tang, Y.L. Shih, C.Tai, Y.Y.Sung, J.L.Huang, H.L.Yang.。2000。 Mice immunized with DNA encodes a modified Pseudomonas aeruginosa exotoxin A develops protective immunity against exotoxin intoxication . Vaccine Vol. 19, issue 9-10, 1106-1112(SCI) .
  8. J.P.R. Rajan, Carmen Lopez, John Han-You Lin, Huey-Lang Yang. 2001。Infection of Vibrio alginolyticus on cultured cobia, Rachycentron canadum in Taiwan. Bulletin of the European Association of Fish pathologist 21(6), 228-235(SCI)
  9. Carmen Lopez, J.P.R. Rajan, John Han-You Lin, Tsun-Yung Kuo & Huey-Lang Yang. 2002 Disease outbreak in seafarmed Cobia (Rachycentron canadum) associate with Vibrio spp., Photbacterium damselae ssp piscida, monogenean and mycosporean parasites Bulletin of the European Association of Fish pathologist 22(3), 206-211.
  10. Lin H-T, Lin J H-Y, Lopez C, Chen Tzong-Yueh, Chen M-S, and Yang H-L. 2008. A Comparison of the Expression of immunity-related rag-1 and ikaros Genes with Histogenesis of the Thymus in Epinephelus malabaricus (Bloch & Schneider). Aquac. Res. 39:252-262. (PDF download)
  11. Chen SP, Yang HL, Her GM, Lin HY, Jeng MF, Wu JL, Hong JR. (2006) Betanodavirus induces phosphatidylserine exposure and loss of mitochondrial membrane potential in secondary necrotic cells, both of which are blocked by bongkrekic acid. Virology 347(2):379-91. (PDF download)
  12. Chen YM, Su YL, Lin JH, Yang HL, Chen TY. (2006)Cloning of an orange-spotted grouper (Epinephelus coioides) Mx cDNA and characterisation of its expression in response to nodavirus. Fish Shellfish Immunol 20(1):58-71. (PDF download)
  13. Chen SP, Yang HL, Lin HY, Chen MC, Wu JL, Hong JR. (2006)Enhanced viability of a nervous necrosis virus-infected stable cell line over-expressing a fusion product of the zfBcl-xL and green fluorescent protein genes. J Fish Dis 29(6):347-54. (PDF download)
  14. Chen Y-M, Su Y-L, Shie P-S, Lin J H-Y, Yang H-L, and Chen Tzong-Yueh. 2008. Grouper Mx Confers Resistance to Nodavirus and Interacts with Coat Protein. Dev. Comp. Immunol. 32:825-836. (PDF download)

 

B. Conference papers

a. International meeting

1.      Han-Tso Lin, C. Lopez, H. Y. Lin and H-L. Yang. How soon the grouper can arm itself?  International symposium on agricultural biotechnology, Dec. 13-14, 2002 Poster award

2.      H.C. Kuo, H.L. Yang and T. Y. Chen, Phylogenetic analysis of the Chinese herb medicine Cordycepes sinensis based on 18 S rRNA gene.  International symposium on agricultural biotechnology, Dec. 13-14, 2002

3.      H.L.Yang. (2001) The application of biotechnology for the development of fish viral vaccine. Taiwan-Japan conference in Biotechnology for Aquatic animals April 2001, Tokyo Japan

4.      Invited speaker (2001) Fish oral vaccine method combining Bio-encapsulation and recombinant DNA technology. Taiwan-Norway-USA International Symposium on fish virus pathogenesis and disease control 2001. Sept. 27-31

5.      Invited speaker (2001) Immuno-response to killed and recombinant subunit vaccines of Nervous necrosis Virus in groper. Taiwan-Norway-USA International Symposium on fish virus pathogenesis and disease control   2001. Sept. 27-31

6.      H.L.Yang. (2001) The development of recombinant subunit vaccine for Nervous Necrosis Virus  International Conference on fish disease: European Fish Pathologist Dublin, Sept. 7-12, 2001

7.      Vibrosis in cultured cobia, Rachycentron canadum, L in Taiwan, Asian aquaculture forum  Nov. 25-29, 2001

8.      Invited speaker (2001) Fish oral vaccine method combining bio-encapsulation and recombinant DNA technology, Asian aquaculture forum Nov. 25-29, 2001

9.      Immuno-response to killed vaccine and recombinant subunit vaccine of nervous necrosis Virus in grouper, Asian aquaculture forum Nov. 25-29, 2001

10.  Invited speaker: The development of vaccination program for NNV infection in grouper, International symposium on agricultural biotechnology, Dec. 13-14, 2002

b. Domestic meeting

1.      Invited speaker 。2001。 Biotechnology for the disease control on aquatic animals, Taiwan Aquaculture Society annual meeting Nov. 24, 2001

2.       The expression of rag-1 and immunoglubin gene and the development of immune system in Cobia, Taiwan Aquaculture Society Annual Meeting Nov. 24, 2001

3.      Isolation, characterization of rag-1 and Ig gene of cobia,  Taiwan Aquaculture Society Annual Meeting Nov. 24, 2001

 

 

E. Other publications

  1. Chien  Tai, Huey-Lang Yang。(2001)。The policy and strategy for the development of biotech industry in Taiwan,  Sci-Tech policy Review SR90010，P761-765。

研究計畫 (至少五年內)

A. National Science Council
  • The development of immune system in grouper (2nd year)  (2002-2003)
  • The development of immune system in grouper (2001-2002)
  • Policy and Strategy for the development of biotech cluster in Southern Taiwan  (2001-2002)
  • The application of immune approach for the production of NNV free larva of grouper (2002-20003)

B. Industry-University collaboration project

  • Biotech education and promotion program-Trangenica animals and vaccine (Ministry of education, 2002)
  • The promotion of key basic advanced research in Institute of biotechnology (Ministry of education, 2001)
  • Establishment of quality control and certification of fish fry (Aquaculture Association, 2001)
  • The development of diagnostic kit for the control of bacterial diseases in cobia (Council of agriculture, 2001)
  • Field efficacy trial of cobia bacterial vaccines (Council of agriculture, 2002)

 

  • 魚DNA疫苗關鍵技術之開發與應用(生物技術國家型計畫,1999-2002)
  • The development of NNV subunit vaccine (National Program for Bio-Agricultural biotechnology, 1998-2001)
  • The development of DNA vaccine for fish (National Program for Bio-Agricultural biotechnology,1999-2002)
  • The development strategy for fish vaccine industry (Bureau of industrial development,1999-2000)

Students (至少五年內)
A. Graduate students
  • Han-Tso Lin (4th year PhD student)
  • Yon-Mau Chen (2nd  year PhD student)
  • Chen-Chu Lin (Master degree student, 2004)
  • Yu-Tin Kung (Master degree student, 2004)
  • Wei-Yi Hsu (Master degree student, 2003)
  • Su-Chin Lin (Master degree student, 2003)
  • Jen-Jei Wang (Master degree student, 2002)
  • Hui-Yun Chen (Master degree student, 2002) 
  • Student received  Hewlett Parker & Far Eastern Economic Review “ Young Inventor Award: Bronze Award” 

Symposium

  • Organizer: Frontier in biotechnology, Tainan, Taiwan, Apr. 1-2, 2002
  • Organizer: Symposium in Chinese herb, Tainan, Taiwan, Dec. 9, 2000
  • Organizer: Symposium in Chinese herb, Taipei, Taiwan Apr. 2, 1999
  • Invited speaker: Japan-Taiwan symposium in aquaculture, Japan
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