吳昭良教授(特聘)

Prof. C.L. Wu 分機 5536 (研究室) 5526 (實驗室)
wumolbio＜at＞mail＜dot＞ncku＜dot＞edu＜dot＞tw
英國愛丁堡大學分子生物學博士 (1993)

研究方向：

研究興趣：

  • 本實驗室的研究主要利用基因治療（包括幹細胞）及奈米技術，從事癌症及其他疾病之標的性治療策略研究。我們以重組病毒及奈米粒子為特異性表現載體，攜帶基因及藥物治療疾病，並研究其作用機轉。我們同時也有部分努力在前胸腺素基因表現調控與訊息傳遞機轉的研究上，並探討前胸腺素生物活性及其在疾病治療之應用。

    • 開授課程：

    分子生 物學    分子技術學    分子遺傳學    轉殖生物學    基因治療概論    基因治療特論    臨床基因治療特論

    Selected publications:

  • Chen, C.Y.+, Shiau, A.L.+, Li, Y.T., Lin, Y.S., Lee, C.H., Wu, C.L.* and Wang, C.R. (2011) Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene. Gene Ther. (Accepted)

  • Lee, C.H., Hsieh, J.L., Wu, C.L., Hsu, H.C., and Shiau, A.L.* (2011). B cells are required for tumor-targeting Salmonella in host. Appl. Microbiol. Biotechnol. 2011 Jun 12. [Epub ahead of print] [Abstract]

  • Yang, M.L., Chen, Y.H., Wang, S.W., Huang, Y.J., Leu, C.H., Yeh, N.C., Chu, C.Y., Lin, C.C., Shieh, G.S., Chen, Y.L., Wang, J.R., Wang, C.H., Wu, C.L.*, and Shiau, A.L. (2011) Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesis. J. Virol. 2011 Oct;85(19):10010-20. Epub 2011 Jul 27. [Abstract]

  • Chen, S.Y., Wu, C.L., Lai, M.D., Lin, C.C., Yo, Y.T., Lee, C.H., Weng, C.T., Shiau, A.L.*, and Wang, C.R. (2011) Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum. Gene Ther. 2011 Feb;22(2):145-54. Epub 2011 Jan 11. [Abstract]

  • Chang, Y.S., Lin, C.F., Wu, C.L., Kuo, P.Y., Wu, F.S., Shieh, C.C., Gean, P.W., Chen, S.T., Chen, M.S., Wu, W.C., Tai, T.H., Tseng, S.H. (2011) Mechanisms underlying benzyl alcohol cytotoxicity (Triamcinolone acetonide preservative) in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4214-22. Print 2011 Jun. [Abstract]

  • Shen, P.C., Shiau, A.L., Jou, I.M., Che-Hsin Lee, C.H., Tai, M.H., Juan, H.Y., Lin, P.R., Liu, G.S., Wu, C.L.*, Hsieh, J.L. (2011) Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis. Exp Biol Med (Maywood). 2011 Mar 1;236(3):334-40. Epub 2011 Mar 4. [Abstract]

  • Lee, C.H., Hsieh, J.L., Wu, C.L., Hsu, P.Y., Shiau, A.L. (2011) T cell augments the antitumor activity of tumor-targeting Salmonella. Appl Microbiol Biotechnol. 2011 May;90(4):1381-8. Epub 2011 Mar 1. [Abstract]

  • Feng, Y.H., Wu, C.L., Tsao, C.J., Chang, J.G., Lu, P.J., Yeh, K.T., Uen, Y.H., Lee, J.C., Shiau, A.L. (2011) Deregulated expression of Sprouty2 and MicroRNA-21 in human colon cancer: Correlation with the clinical stage of the disease. Cancer Biology and Therapy 11: 98-108. [Abstract]

  • Lin, H.Y., Wu, C.L., Huang, C.C. (2010 ) The Akt-endothelial nitric oxide synthase pathway in lipopolysaccharide preconditioning-induced hypoxic-ischemic tolerance in the neonatal rat brain. Stroke. 2010 Jul;41(7):1543-51. Epub 2010 May 27. [Abstract]

  • Yang, H.J., Yen, M.C., Lin, C.C., Lin, C.M., Chen, Y.L., Weng, T.Y., Huang, T.T., Wu, C.L., Lai, M.D. (2010) A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. Exp Biol Med (Maywood). 2010 Jul;235(7):869-76. [Abstract]

  • Feng YH, Tsao CJ, Wu CL, Chang JG, Lu PJ, Yeh KT, Shieh GS, Shiau AL, Lee JC. (2010) Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells. Cancer Sci. 2010 Sep;101(9):2033-8. doi: 10.1111/j.1349-7006.2010.01637.x. [Abstract]

  • Shiau AL, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao J, Chao L, Wu CL, Lee CH. (2010) Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin. BMC Cancer. 2010 May 31;10:245. [Abstract]

  • Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH, Yo YT, Lo CW, Lin YS, Juan HY, Chen YL, Wu CL. (2010) Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis. Gene Ther. 2010 Oct;17(10):1225-33. Epub 2010 Jun 3. [Abstract]

  • Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Wang CR, Teo ML, Wu CL. (2010) Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J Orthop Res. 2010 Oct;28(10):1300-6. [Abstract]

  • Tsai YS, Shiau AL, Chen YF, Tsai HT, Tzai TS, Wu CL. (2010) Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy. Cancer Gene Ther. 2010 Jan;17(1):37-48. Epub. [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2010) Toll-like receptor 4 signaling promotes tumor growth. J Immunother. 2010 Jan;33(1):73-82. [Abstract]

  • Chen SY, Shiau AL, Shieh GS, Su CH, Lee CH, Lee HL, Wang CR, Wu CL. (2009) Amelioration of experimental arthritis by a telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts. Arthritis Rheum. 2009 Oct 29;60(11):3290-3302. [Abstract]

  • Yo YT, Shieh GS, Hsu KF, Wu CL, Shiau AL. (2009) Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem. 2009 Sep 23;57(18):8266-73. [Abstract]

  • Jou YC, Tung CL, Tsai YS, Shen CH, Syue-Yi C, Shiau AL, Tsai HT, Wu CL, Tzai TS. (2009) Prognostic relevance of prothymosin-alpha expression in human upper urinary tract transitional cell carcinoma. Urology. 2009 Oct;74(4):951-7. [Abstract]

  • Su WC, Liu WL, Cheng CW, Chou YB, Hung KH, Huang WH, Wu CL, Li YT, Shiau AL, Lai MY. (2009) Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. FEBS Lett. 2009 Sep 3;583(17):2793-8. [Abstract]

  • Tsai YS, Shiau AL, Chen YF, Tsai HT, Lee HL, Tzai TS, Wu CL. (2009) Enhancement of antitumor immune response by targeted interleukin-12 electrogene transfer through antiHER2 single-chain antibody in a murine bladder tumor model. Vaccine. 2009 Aug 27;27(39):5383-92. [Abstract]

  • Tsai YS, Shiau AL, Chen YF, Tsai HT, Tzai TS, Wu CL. (2009) Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy. Cancer Gene Ther. 2009 Jun 19. [Abstract]

  • Lee CH, Wu CL, Chen SH, Shiau AL. (2009) Humoral immune responses inhibit the antitumor activities mediated by Salmonella enterica serovar choleraesuis. J Immunother. 2009 May;32(4):376-88. [Abstract]

  • Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, Wu FS, Chuang JI, Jen CJ. (2009) Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. J Physiol. 2009 Jul 1;587(Pt 13):3221-31. [Abstract]

  • Hsu KF, Wu CL, Huang SC, Wu CM, Hsiao JR, Yo YT, Chen YH, Shiau AL, Chou CY. (2009) Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy. 2009 May;5(4):451-60. [Abstract]

  • Hsieh JL, Lee CH, Teo ML, Lin YJ, Huang YS, Wu CL, Shiau AL. (2009) Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma. Cancer Sci. 2009 Mar;100(3):537-45. [Abstract]

  • Hsieh J, Shen PC, Shiau AL, Jou IM, Lee CH, Teo ML, Wang CR, Chao J, Chao L, Wu CL. (2009) Adenovirus-Mediated Kallistatin Gene Transfer Ameliorates Disease Progression in a Rat Model of Osteoarthritis Induced by Anterior Cruciate Ligament Transection. Hum Gene Ther. 2009 20: 147-158. [Abstract]

  • Tsai YS, Jou YC, Lee GF, Chen YC, Shiau AL, Tsai HT, Wu CL, Tzai TS. (2009) Aberrant prothymosin-alpha expression in human bladder cancer. Urology. 2009 Jan;73(1):188-92. [Abstract]

  • Hsieh J, Shen PC, Shiau AL, Jou IM, Lee CH, Teo ML, Wang CR, Chao J, Chao L, Wu CL. (2008) Adenovirus-Mediated Kallistatin Gene Transfer Ameliorates Disease Progression in a Rat Model of Osteoarthritis Induced by Anterior Cruciate Ligament Transection.Hum Gene Ther. 2008 Nov 11. [Epub ahead of print] [Abstract]

  • Chang CC, Shieh GS, Wu P, Lin CC, Shiau AL, Wu CL. (2008) Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res. 2008 Aug 1;68(15):6281-91. [Abstract]

  • Wang CR, Shiau AL, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT, Lee CH, Kuo SM, Liu MF, Jou IM, Yang CY, Shen PC, Lee HL, Wu CL. (2008) Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer. Arthritis Rheum. 2008 Jun;58(6):1650-6. [Abstract]

  • Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL. (2008) Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice. Cancer Sci. 2008 Jul;99(7):1479-84. Epub 2008 Apr 11. [Abstract]

  • Chang YS, Chen WC, Tseng SH, Sze CI, Wu CL. (2008) Subconjunctival mitomycin C before pterygium excision: an ultrastructural study. Cornea. 2008 May;27(4):471-5. [Abstract]

  • Wu CL, Shieh GS, Chang CC, Yo YT, Su CH, Chang MY, Huang YH, Wu P, Shiau AL. (2008) Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res. 2008 Feb 15;14(4):1228-38. [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2008) Toll-like receptor 4 mediates an antitumor host response induced by Salmonella choleraesuis. Clin Cancer Res. 2008 Mar 15;14(6):1905-12. [Abstract]

  • Wu CL, Shieh GS, Chang CC, Yo YT, Su CH, Chang MY, Huang YH, Wu P, Shiau AL. (2008) Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res. 2008 Feb 15;14(4):1228-38. [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2008) Salmonella choleraesuis as an anticancer agent in a syngeneic model of orthotopic hepatocellular carcinoma. Int J Cancer. 2008 Feb 15;122(4):930-5. [Abstract]

  • Wang CR, Chen SY, Shiau AL, Wu CL, Jou IM, Chao L, Chao J. (2007) Upregulation of kallistatin expression in rheumatoid joints. J Rheumatol. 2007 Nov;34(11):2171-6. [Abstract]

  • Chu CY, Wang SY, Chen ZW, Chien MS, Huang JP, Chen JJ, Hong LS, Shiau AL, Tsai JL, Wu CL. (2007) Heterologous protection in pigs induced by a plasmid-cured and crp gene-deleted Salmonella choleraesuis live vaccine. Vaccine. 2007 Oct 10;25(41):7031-40. [Abstract]

  • Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, Chen DH, Wang CR, Shiau AL, Wu CL. (2007) Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm. 2007 Sep-Oct;4(5):713-22. [Abstract]

  • Yo YT, Hsu KF, Shieh GS, Lo CW, Chang CC, Wu CL, Shiau AL. (2007) Coexpression of Flt3 ligand and GM-CSF genes modulates immune responses induced by HER2/neu DNA vaccine. Cancer Gene Ther. 2007 Nov;14(11):904-17. [Abstract]

  • Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT, Wang CR, Wu CL. (2007) Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol. 2007 Apr 1;178(7):4688-94. [Abstract]

  • Tsai CY, Shiau AL, Chen SY, Chen YH, Cheng PC, Chang MY, Chen DH, Chou CH, Wang CR, Wu CL. (2007) Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum. 2007 Feb;56(2):544-54. [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2007) Hypoxia-induced cytosine deaminase gene expression for cancer therapy. Hum Gene Ther. 2007 Jan;18(1):27-38. [Abstract]

  • Shiau AL, Lin YP, Shieh GS, Su CH, Wu WL, Tsai YS, Cheng CW, Lai MD, Wu CL. (2007) Development of a Conditionally Replicating Pseudorabies Virus for HER-2/neu-overexpressing Bladder Cancer Therapy. Mol Ther. 2007 Jan;15(1):131-8. [Abstract]

  • Chen YC, Chang MY, Shiau AL, Yo YT, Wu CL. (2007) Mitochondrial ribosomal protein S36 delays cell cycle progression in association with p53 modification and p21(WAF1/CIP1) expression. J Cell Biochem. 2007 Mar 1;100(4):981-90. [Abstract]

  • Chang YS, Wu CL, Tseng SH, Kuo PY, Tseng SY. (2007) Cytotoxicity of triamcinolone acetonide on human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2792-8. [Abstract]

  • Tsai CY, Shiau AL, Chen SY, Chen YH, Cheng PC, Chang MY, Chen DH, Chou CH, Wang CR, Wu CL.(2007) Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum. 2007 Jan 30;56(2):544-554 [Epub ahead of print] [Abstract]

  • Shieh GS, Shiau AL, Yo YT, Lin PR, Chang CC, Tzai TS, Wu CL. (2006) Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model. Cancer Res. 2006 Oct 15;66(20):9957-66. [Abstract]

  • Chang YS, Tseng SY, Tseng SH, Wu CL, Chen MF. (2006) Triamcinolone acetonide suspension toxicity to corneal endothelial cells. J Cataract Refract Surg. 2006 Sep;32(9):1549-55. [Abstract]

  • Chang YS, Tseng SY, Tseng SH, Wu CL. (2006) Cytotoxicity of lidocaine or bupivacaine on corneal endothelial cells in a rabbit model. Cornea. 2006 Jun;25(5):590-6. [Abstract]

  • Tzai TS, Tsai YS, Shiau AL, Wu CL, Shieh GS, Tsai HT. (2006) Urine prothymosin-alpha as novel tumor marker for detection and follow-up of bladder cancer. Urology. 2006 Feb;67(2):294-9. [Abstract]

  • Tsai YS, Tzai TS, Chow NH, Wu CL. (2005) Frequency and clinicopathologic correlates of ErbB1, ErbB2, and ErbB3 immunoreactivity in urothelial tumors of upper urinary tract. Urology. 2005 Dec;66(6):1197-202. [Abstract]

  • Shiau AL, Chen CC, Yo YT, Chu CY, Wang SY, Wu CL. (2005) Enhancement of humoral and cellular immune responses by an oral Salmonella choleraesuis vaccine expressing porcine prothymosin alpha. Vaccine. 2005 Dec 1;23(48-49):5563-71. Epub 2005 Jul 19. [Abstract]

  • Shieh DB, Cheng FY, Su CH, Yeh CS, Wu MT, Wu YN, Tsai CY, Wu CL, Chen DH, Chou CH. (2005) Aqueous dispersions of magnetite nanoparticles with NH3+ surfaces for magnetic manipulations of biomolecules and MRI contrast agents. Biomaterials. 2005 Dec;26(34):7183-91. [Abstract]

  • Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J. (2005) Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum. 2005 Apr;52(4):1319-24. [Abstract]

  • Lee CH, Wu CL, Tai YS, Shiau AL. (2005) Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy. Mol Ther. 2005 May;11(5):707-16. [Abstract]

  • Li KJ, Shiau AL, Chiou YY, Yo YT, Wu CL. (2005) Transgenic overexpression of prothymosin alpha induces development of polycystic kidney disease. Kidney Int. 2005 May;67(5):1710-22. [Abstract]

  • Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, Wu CL. (2005) Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis. Arthritis Rheum. 2005 Jan;52(1):339-44. [Abstract]

  • Shiau AL, Liu PS, Wu CL. (2005) Novel strategy for generation and titration of recombinant adeno-associated virus vectors. J Virol. 2005 Jan;79(1):193-201. [Abstract]

  • Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB. (2005) Characterization of aqueous dispersions of Fe(3)O(4) nanoparticles and their biomedical applications. Biomaterials. 2005 Mar;26(7):729-38. [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2005) Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model. Cancer Gene Ther. 2005 Feb;12(2):175-84. [Abstract]

  • Tsai, C.Y., Shiau,A.L., Cheng, P.C., Shieh, D.B., Chen, D.H., Chou, C.H., Yeh, C.S., and Wu,C.L. (2004). A biological strategy for fabrication of Au:EGFP nanoparticleconjugates retaining bioactivity. Nano Letters 4: 1209-1212. (SCI) [Abstract]

  • Lee CH, Wu CL, Shiau AL. (2004) Endostatin gene therapy delivered by Salmonella choleraesuis in murine tumor models. J Gene Med. 2004 Dec;6(12):1382-93. [Abstract]

  • Jen CP, Chen YH, Fan CS, Yeh CS, Lin YC, Shieh DB, Wu CL, Chen DH, Chou CH. (2004) A nonviral transfection approach in vitro: the design of a gold nanoparticle vector joint with microelectromechanical systems. Langmuir. 2004 Feb 17;20(4):1369-74. [Abstract]

  • Hsiao, J.R., Jin, Y.T., Tsai, S.T., Shiau, A.L., Wu, C.L., and Su, W.C. (2003) Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Brit. J. Cancer. 2003 Jul 21;89(2):344-9. [Abstract]

  • Hsieh, J.L., Wu, C.L., Lai, M.D., Lee, C.H., and Shiau, A.L. (2003) Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1-5. Br J Cancer. 2003 May 6;88(9):1492-9. [Abstract]

  • Hsieh, J.L., Wu, C.L., Lee, C.H., and Shiau, A.L. (2003) Hepatitis B Virus X Protein Sensitizes Hepatocellular Carcinoma Cells to Cytolysis Induced by E1B-deleted Adenovirus through the Disruption of p53 Function. Clin Cancer Res 2003 Jan;9(1):338-45. [Abstract]

  • Lu, C.Y., Chou, A.K., Wu, C.L., Yang, C.H., Chen, J.T., Wu, P.C., Lin, S.H., Muhammad, R., and Yang, L.C. (2002) Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats. Gene Ther 2002 Aug;9(15):1008-14. [Abstract]

  • Chou, A.K., Muhammad, R., Huang, S.M., Chen, J.T., Wu, C.L., Lin, C.R., Lee, T.H., Lin, S.H., Lu, C.Y., and Yang, L.C. (2002).Altered synaptophysin expression in the rat spinal cord after chronic constriction injury of sciatic nerve. Neurosci Lett 2002 Nov 29;333(3):155-8. [Abstract]

  • Shiau, A.L., Liu, C.W., Tsai, C.Y., Wang, S.Y., and Wu, C.L. (2002) A simple selection system for construction of recombinant gD-negative pseudorabies virus as a vaccine vector. Vaccine 2002 Jan 15;20(7-8):1186-95. [Abstract]

  • Shiau, A.L., Lin, P.R., Chang, M.Y., and Wu, C.L. (2001) Retrovirus-mediated transfer of prothymosin gene inhibits tumor growth and prolongs survival in murine bladder cancer. Gene Ther 2001 Nov;8(21):1609-17. [Abstract]

  • Shiau, A.L., Chen, Y.L., Liao, C.Y., Huang, Y.S., and Wu, C.L. (2001) Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis. Vaccine 2001 Jul 16;19(28-29):3947-56. [Abstract]

  • Shiau, A.L., Lin, C.Y., Tzai, T.S., and Wu, C.L. (2001) Postoperative immuno-gene therapy of murine bladder tumor by in vivo administration of retroviruses expressing mouse interferon-γ. Cancer Gene Ther 2001 Jan;8(1):73-81. [Abstract]

  • Shiau, A.L., Chu, C.Y., Su, W.C., and Wu, C.L. (2001) Vaccination with the glycoprotein D gene of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits protective immune responses. Vaccine 2001 Apr 30;19(23-24):3277-84. [Abstract]

  • Tzai, T.S., Shiau, A.L., Liu, L L., and Wu, C.L. (2000) Anticancer Res 2000 May-Jun;20(3A):1557-62. Immunization with TGF-beta antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions. Anticancer Res 2000 May-Jun;20(3A):1557-62. [Abstract]

  • Yang, W.H., Peng, H.H., Chang, H.C., Shen, S.Y., Wu, C.L., and Chang, C.H. (2000) An in vitro monitoring system for simulated thermal process in cryosurgery. Cryobiology 2000 Mar;40(2):159-70. [Abstract]

  • Tzai TS, Shiau AL, Wu CL, Tsai YS. (2000) Postoperative administration of interleukin-12 significantly enhances the anti-tumor immune response of MBT-2 bladder cancer bearing mice. Proc Natl Sci Counc Repub China B. 2000 Apr;24(2):56-62. [Abstract]

  • Wu, C.L., Wu, P., and Shiau, A.L. (1999) A computerized management system for cell bank. Anal Biochem 1999 Nov 15;275(2):260-2. [Abstract]

  • Wu, C.L., Leu, T.S., Chang, T.T., and Shiau, A.L. (1999) Hepatitis C virus core protein fused to hepatitis B virus core antigen for serological diagnosis of both hepatitis C and hepatitis B infections by ELISA. J Med Virol 1999 Feb;57(2):104-10. [Abstract]

  • Shiau, A.L., Yang, H.M., Wu, P., and Wu, C.L. (1998) Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Ther 1998 Nov;5(11):1571-4. [Abstract]

  • Tzai, T.S., Shiau, A.L., Wu, C.L., Chou, N.H., and Tsai, Y.S. (1998) Modulating the antitumor immunity of MBT-2 murine bladder tumor bearing mice by postoperative administration of interferon-alpha. Anticancer Res 1998 Sep-Oct;18(5A):3355-61. [Abstract]

  • Tzai, T.S., Lin, C.I., Shiau, A.L., and Wu, C.L. (1998) Antisense oligonucleotide specific for transforming growth factor-beta 1 inhibit both in vitro and in vivo growth of MBT-2 murine bladder cancer. Anticancer Res 1998 May-Jun;18(3A):1585-9. [Abstract]

  • Shiau, A.L., and Wu, C.L. (1998) The inhibitory effect of Staphylococcus epidermidis slime on the phagocytosis of murine peritoneal macrophages is interferon-independent. Microbiol Immunol 1998;42(1):33-40. [Abstract]

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