NCKU, Department of Cell Biology and Anatomy

Sze C-I, M.D.

 

司君一   副教授

Education

· 美國德州Tech大學健康科學中心醫學院醫學博士

Office: 886-6-2353535 ext 5329

Lab: 886-6-2353535

Fax: 886-6-2093007

E-mail: szec@mail.ncku.edu.tw

 

Contact information

Department of Cell Biology and Anatomy

National Cheng-Kung University College of Medicine

1 University Road

Tainan 70101

Taiwan

 

 

Publication

1. Lee RS, Chang KC, Chen SH, Sze, C-I. Dural based maliganat sweat gland tumor:  case report. J. Neurooncology, Accepted 1/4/2010.

2. Hong Q, Sze C-I, Lin SR, Lee MH, He RY, Schultz L, Chang JY, Chen SJ, Boackle RJ, Hsu LJ, Chang NS. Complement C1q avtivates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. PLoS One 2009;4: e5775 1-13.

3. Li MY, Lai FJ, Hsu LJ, Lo CP, Cheng CL, Lin SR, Lee MH, Chang JY, Subhan D, Tsai MS, Sze CI, Pugazhenthi S, Chang NS, Chen ST. Dramatic Co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transaction in rats.  PLoS One. 2009 Nov 12;4(11):e7820. Contributed equally to the first three authors

4. Chang YS, Chen WC, Tseng SH, Sze C-I, Wu CL. Subconjunctival Mitomycin C before  pterygium excision; An ultrastructual study. Cornea 2008: 27; 471-475

5. F.A. Dilmanian, Qu Y, Liu S, Cool CD, Gilbert J, Hainfeld JF, Kruse CA,  Laterra J,  Lenihan D, Nawrocky MM, Pappas G, Sze C-I, Yuasa T, Zhong N, Zhong Z, McDonald JW. X-ray Microbeams: X ray microbeams: Tumor therapy and central nervous system research. Nuclear instruments & methods in physics research A 548, 2005:30-37.

6. Hideko-Matten R, Read SB, Pierschbacher MD, Sze C-I, Kruse CA. Glioma cell Integrin expression and their interactions with integrin antagonists. Cancer therapy 2005:3; 325-40.

7. Sze C-I, Su M, Pugazhenthi S, Purevsuren J, Hsu LJ, Heath J, Schultz L, Chang NS. Downregulation of WW-domain-containing oxidoreductase WOX1 induces Tau phosphorylation in vitro: A potential role in Alzheimer’s disease. J Biol Chem 2004;279:30498-506.

8. Chang NS, Schultz L, Hsu LJ, Lewis J, Su M, Sze C-I. 17β-estradiol upregulates and activates  WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and  prostate to a premetastatic state in vivo. Oncogene, 2004 Dec 06; [Epub ahead print]

9. Sze C-I, Huffer W, Kindt G, Chang M, DeMasters BK. Synovial excrescences and cysts of the spine: clinicopathological features and contributions to spinal stenosis. Clin Neuropathology 2004; 23:80-90.

10. Lopez JA, Kleinschmidt-DeMasters BK B, Sze C-I, Woodmansee WW, Lillehei KO. Silent corticotroph adenomas: further clinical and pathological observations. Human Pathology 2004;35:1137-47. 7. 

11. McDuffie RS Jr, Kunze M, Barr J, Wolf D, Sze C-I, Shikes R, Sherman M, Gibbs RS. Experimental intrauterine infection with prevotella bivia in New Zealand white rabbits. Am J Obstet Gynecol 2004; 190:1082-86.

12. Sze C-I, Huffer W, Breeze R, Escott E, DeMasters BK. Cholesterol granulomas-     clinicopathologic  correlates of three cases. Clin Neuropathology 2003; 22:41-46.

13. McDuffie RS Jr, Kunze M, Barr J, Wolf D, Sze C-I, Shikes R, Sherman M, Gibbs RS.   Chronic intrauterine and fetal infection with Gardnerella Vaginalis. Am J Obstet Gynecol 2002; 187: 1262-6.

14. Bi H, Sze C-I. NMDA receptor subunit NR2A and NR2B messenger RNA levels are   altered in the  hippocampus and entorhinal cortex in Alzheimer’s disease. J Neurol Sci 2002; 200:11-8.

15. Escott EJ, Rubinstein D, Cajade-Law AG, Sze C-I. Suprasellar cavernous  malformation presenting with extensive subarachnoid hemorrhage. Neuroradiology, 2001; 43: 313-6.

16. Sze C-I, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ.  NMDA receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer’s disease.  J Neurol Sci 2001;182:151-59.

17. Davies JK, Shikes RH, Sze C-I, Leslie KK, McDuffie Jr RS, Romero R, Gibbs RS,   Histologic  inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection. Am J. Obstst Gynecol. 2000;183:1088-93.

18. Sze C-I, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ.  Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains.  J. Neurol Sci. 2000; 175:81-90.

19. Yee AS, Simon JH, Anderson CA, Sze C-I, Filley CM.  Diffuse-weighted MRI of right hemisphere dysfunction in Creutzfeldt-Jakob disease.  Neurology 1999;52:1514-1515.

20. Frost M, Huffer WE, Sze C-I, Badesch D, Cajade-Law AG, Kleinschmidt-DeMasters BK. Cervical spine  abnormalities in Down syndrome: A pathologic-radiographic correlation study and literature review.  Clin Neuropathology 1999; 18:250-259.

21. Filley CM, Thompson LL, Sze C-I, Simon JA, Paskavitz JA, Kleinschmidt-DeMasters BK.  White matter dementia in CADASIL. J Neurol Sci 1999;163:163-167.

22. Sze C-I, Mahalingam R, Wellish M, Levy AS, Wu E, Pfister SJ, Gilden DH, Kleinschmidt-DeMasters BK. Attempts to identify herpes simplex virus DNA in normal and diseased human peripheral nerve. Neurology  1999; 52:1293-1295.

23. Kleinschmidt-DeMasters BK, Mierau GW, Sze C-I, Breeze RE, Greffe B, Lillehei KO, Stephens JK, Unusual dural and skull-based mesenchymal neoplasms: A report of Four Cases. Human Pathol, 1998; 29:240-45.

24. Kleinschmidt-DeMasters BK. Hashizumi TL. Sze C-I. Lillehei KO.  Shroyer AL. Shroyer KR. Telmerase  expression shows differences across multiple regions of oligodendriglioma versus high grade astrocytomas  but shows correlation with Mib-1 labeling. J. Clinic Pathol 1998; 51:284-93.

25. Sze C-I, Troncoso JC, Kawas CH, Mouton PR, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer’s disease. J Neuropathol Exp Neurol 1997; 56:933-44.

26. Crain BJ, Hu W, Sze C-I, Slunt HH, Koo EH, Price DL, Thinakaran G, Sisodia SS. Expression and distribution of amyloid precursor protein-like protein 2 in Alzheimer’s disease and in normal brain. Am  J  Pathol 1996:149:1087-95.

27. Sze C-I, Tung SH, Shih JT. Recording of Frog’s EKG, Biological Bulletin, National Taiwan Normal University, 1979.

　

Abstracts, Symposium, and Book Chapters

 

1. Sze C-I, Sun W, Lieberman R, Purchio T, Gerschenson LE. Progesterone regulates apoptosis,  Transformation growth factor-b1(TGF-b1) immunostain patterns and TGF-b1 mRNA contents in rabbit uterine epithelium. The FASEB Journal Abstract, Vol.7, No. 3, Part 1, A789. 1993.

2. Gerschenson LE, Rotello RJ, Lieberman R, Sze C-I. Apoptosis: Definition, roles and regulation. Abstract,  The Cell Cycle ’93. Regulators, Targets And Clinical Applications, XIIIth  Washington International Spring Symposium.

3. Gerschenson LE, Rotello RJ. Lieberman R, Sze C-I. Apoptosis: Definition, roles and Regulation. In: The Cell Cycle: Regulators, targets and Clinical Applications (VW Hu, Ed.), Plenum Publishing Co., New York, NY, pp. 291-299, 1994.

4. Sze C-I, Troncoso JC, Kawas CH, Mouton PR, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with early cognitive decline in aged humans. Society for Neuroscience Abstracts, Vol.22, Part I, 83.5, 1996.

5. Kleinschmidt-DeMasters BK, Hashizumi T, Lillehei KO, Sze C-I, Shroyer KR.  Correlation of regional telomerase expression in GBMs and oligodendrogliomas with histological features and MIB-1 labeling. Abstract, AANP meeting, June 1997. Honorable Mention for the Rubinstein Award, J Neuropathol Exp Neurol, 1997; 56:1068

6. Kleinschmidt-DeMasters BK, Sze C-I, Breeze RE, Greff B, Lillehei KO, Stephens JK, Winston KR. Rare intracranial mesenchymal neoplasm: A report of four cases.  Abstract, The fortieth Annual Clinical Conference, Cancer and the Central Nervous System, March 1-4, 1997.

7. Sze C-I, Levy AS, Mahalingham R, Wu E, Pfister SJ, Kleinschmidt-Demasters BK. Is viral infection a cause of critical illness polyneuropathy (CIP)? Abstract, J Neuropathol Exp Neurol 1998; 57:478.

8. Sze C-I, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ.  Selective loss of synaptic vesicle proteins in Alzheimer’s disease. Abstract, FASEB J, 1999;152.3.

9. Bi H, Sze C-I, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ.  Synaptobrevin may be an early marker for Alzheimer’s disease. Abstract, J Neuropathol Exp Neurol 1999; 58: 532.12.

10. Sze C-I, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ.  Selective regional alteration of N-Methyl-D-Aspartate receptor proteins NR2A and NR2B in Alzheimer’s disease and clinical correlation with memory impairment. Abstract, J Neuropathol Exp Neurol 1999; 58: 558.

11. Davis J, Sze C-I, Lee S, Woodcock S, McDuffie RS, Gibbs RS.  Inflammation and increased apoptosis is not found in the fetal  brain following short course intra-amniotic infection in the rabbit.  Abstract, Society for Maternal-Fetal Medicine, 2000 annual meeting, 1/31-2/5, 2000, Miami Beach, Florida.

12. Sze C-I, Browning M, Bi H.  NMDA receptor subunit mRNA levels are altered selectively in AD brains.  Abstract, Society for Neuroscience abstract, volume 26, part 2, 576.6, 2000.

13. McDuffie R,  Kunze M,  Barr J, Wolf D, Sze C-I, Shikes R, Sherman M, Gibbs R. Chronic intrauterine and fetal infection with G. Vaginalis (GV). Abstract, Present to Society for Maternal and Fetal Medicine, 1/18/2002.

14. Sze C-I, Su M, Chang NS. Distribution of WOX1 – A mitochondrial oxidoreductase inAlzheimer’s disease and normal age-matched human brains. Abstract. Present to American Association of Neuropathology (AANP) meeting, 6/2002, Denver.

15. Nordstrom T, Sze C-I, Nornes HO. An alternative method to isolate neural progenitor cells from posmortem adult human CNS. Abstract. Present to AANP meeting, 6/2002.

16. Sze C-I, Pugazhenthi S, Chang NS. WW domain-containing oxidoreductase is altered in Alzheimer’s disease. Coleman Institute Workshop, “Exploring research frontiers and partnerships in cognitive disability II”, Boulder, CO. 9/2002

17. Jambal P, Nesterrova A, Audesirk G, Kern M, Cabell L, Sze C-I, Reusch JEB, Pugazhenthi S. Protection of hippocampal neurons by the transcription factor CREB from beta amyloid-induced injury. Coleman Institute Workshop, “Exploring research frontiers and partnerships in cognitive disability II”, Boulder, CO. 9/2002.

18. Dilmanian FA, Gatley SJ, Hainfeld JF, Morris GM, Rosen EM, Laterra JS, Kalef- Ezra J, Kruse CA, Cool CD, Sze C-I, Microbeam radiation therapy, The American Chemical Society annual meeting, March 23-27, 2003, New Orleans.

19. Dilmanian FA, Hainfeld JF, Kruse CA, Cool CD, Sze C-I, Laterra JS, Feldman A, Gatley SJ, Nawrocky MM and Yakupov R. (2003) Biological mechanisms underlying the x-ray microbeam effects of preferentially destroying tumors. National Synchrotron Light Source Activity Report 2002, M.A. Corwin and S.N. Ehrlich, Eds., May 2003.

20. Dilmanian FA, Hainfeld JF, Kruse CA, Cool CD, Sze C-I, Berens ME, Maehara R, Feldman A, and Zhong N. (2003) Direct granular cell death in the rat cerebellum observed in the paths of very high dose x-ray microbeams. National Synchrotron Light Source Activity Report 2002, M.A. Corwin and S.N. Ehrlich, Eds., May 2003. 

21. Hsu L, Sze C-I, Pugazhenthi S, Heath J, Schultz L, Chang N-S (2003).  Downregulation of WOX1 induces Tau phosphorylation in vitro:  A potential role in Alzheimer’s disease.  American Society of Cell Biology meeting 2003, San Francisco, CA.

22. Rollins YD, Anderson A, Arciniegas DB, Sze C-I, Woodcock JH, Craig AH, Lawrence MA, Kleinschmidt-DeMasters BK, Filley CM. Alzheimer’s disease before age 35: case report and literature review. The 56th Annual Meeting of American Academy of Neurology, 4/2004, San Francisco, CA.

23. Dilmanian A, Qu Y, Liu S, Hainfeld J, Steidinger T, Sze C-I, Yakupov R, McDonald JW. Selective demyelination with minimal axonal or vascular injury induced by high-dose synchrotron-generated X-ray microbeams. Present to Radiation Research Society Annual Meeting 4/2004, St. Louis, MI.

24. Reusch JEB, Sturek M, Mokelke EA, Grippa J, Su M, Sze C-I, Ohman R, Pugazhenthi S. Chronic hyperglycemia impairs cytoprotective CREB function in the diabetic nervous system. Present to American Diabetic Association 64 Scientific Sessions, 6/2004, Orlando, FL.

25. Sze C-I, Su M, Pugazhenthi S, Richards RI, Hsu LJ, Heath J, Schultz L, Chang NS. Downregulation of WOX1 induces Tau phosphorylation in vitro: The molecular mechanism and its potential role in Alzheimer’s disease. Present to the 9th International Conference on Alzheimer’s disease and Related Disorders, 7/17/2004 to 7/22/2004, Philadelphia. PA. 

26. Sze C-I, Su M, Heasley L. Dorsal root ganglia are stressed in mouse models of diabetic neuropathy. Presented to Society of Neuroscience 35th annual meeting, 11/2005, Washington D.C.

27. Sze C-I, Chen ST, Chiang MF, Chang NS. WW domain-containing oxidoreductase WOX1 is upregulated in certain types of central nervous systems tumors. Presented to EB2007 meeting, 4/28-5/2/2007, Washington D.C.

28. Sze C-I, Huang YF, Hsieh CL, Li MY. Stem cell marker immunoprofile in glioblastomas and its potential role in tumorigenesis. Presented to EB2008 meeting, 4/5-4/9/2008, San Diego, USA.

29. Sze C-I, Huang YF, Lee MH, Chang NS. Role of WWOX in HA/CD44/Hyal/merlin signaling. American association of Cancer Research, 100th Annual Meeting 2009, Denver, CO. USA

30. Lin YC, Tsai TS, Lin YJ, Lin CH, Sze C-I. Timing of single postnatal dexamethasone therapy on the hippocampus formation in the rat pups. American Society for Pediatrics Research Annual Meeting, 2009

31. Hsieh CL, Sze C-I. The Response of Glioblastoma Multiform After Radiation. 生物醫學年會，台北，台灣，3/21-3/22, 2009

32. Sze C-I , Hsieh CL, Tsai R, Sze J, Huang YF, Ho SY. The Effects of irradiation on glioblastoma cell lines: a potential tool to study the mechanism of tumor resistance. Presented to EB2010 meeting, 4/24-4/28/2010, Anaheim, CA, USA.

33. Lin YC, Tsai TS, Lin YJ, Lin CH, Sze C-I. The effects of a single dose of dexamethasone on hippocampal neuronal death, and its correlation to nestin expression in rat pups.  Society for Pediatrics Research annual meeting, 5/2010, Vancouver, Canada.

 

 

Students

碩士班學生：

· 謝佳莉

· 張立德

· 曹智捷

· 張嘉仁

· 楊雅婷

· 沈宛柔

博士班學生：

· 鄧志娟

· 羅振鵬

· 羅振鵬