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NCKU, Department of Cell Biology and Anatomy |
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Jung-Yu C. Hsu, Ph.D.
許鍾瑜 助理教授 |
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Education |
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· Ph.D. in Neurobiology, Saint Louis University School of Medicine, St. Louis, Missouri, U.S.A. (2002) · M.S., Institute of Anatomy and Cell Biology, National Yang-Ming University, Taipei, Taiwan. (1992) · B.S., School of Medical Technology, Chung-Shan Medical University, Taichung, Taiwan. (1990) |
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Contact information Department of Cell Biology and Anatomy National Cheng-Kung University College of Medicine 1 University Road Tainan 70101 Taiwan
E-mail: Office Phone: Fax: |
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Research Interests |
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Dr. Hsu's research has long focused on axonal plasticity in the central nervous system, particularly in the field of axonal regeneration and wound healing after spinal cord injury. He is investigating how non-neuronal cells and matrix molecules regulate axonal regrowth and tissue repair during wound healing. His research will elucidate the mechanism underlying the formation of an astroglial scar in injured spinal cord and the roles of astrocytes in repairing damaged blood vessels during wound healing. His ultimate goal is to better understand how to create a promotive environment that fosters axonal regeneration and recovery of motor function after spinal cord injury.
Dr. Hsu encourages undergraduate and graduate students interested in neurobiology to join his research team. Clinicians and particularly international scholars are also welcomed to bring their special areas of expertise together to a multidisciplinary effort dedicating to translational research.
脊髓受到外力傷害之後﹐會導致傷患不同程度的運動功能喪失或癱瘓､自主神經失調､以及無以名狀的劇烈疼痛｡ 造成這些生理功能缺損的主因是由於脊髓中數以萬計的神經纖維被外力截斷而無法傳遞神經訊號﹐繼之而來的出血及發炎反應雪上加霜﹐會更進一步擴大受損的神經組織｡
許鍾瑜博士多年致力於研究脊髓受傷後神經纖維的再生與組織修復｡ 他發現一些會影響神經纖維再生的物質﹐包括某種特殊蛋白酶 (matrix metalloproteinases)以及疤痕組織 (astroglial scar)｡ 他也觀察到受傷的脊髓組織出現異常的新血管生成反應 (angiogenesis)｡ 許博士歡迎有共同研究興趣的研究生､國際學者､以及臨床醫師加入他的研究團隊﹐共同努力尋找治療的對策與方法﹐幫助坐在輪椅上脊髓受創的傷患再度邁出他們的步伐｡ |
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Professional Experiences |
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Research Associate, Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan. (2008) Postdoctoral Scholar, Department of Neurological Surgery, University of California, San Francisco, California, U.S.A. (2002) Teaching Fellow, School of Dentistry, University of California, San Francisco, California, U.S.A. (2005) Teaching Assistant, Department of Anatomy and Cell Biology, National Yang-Ming University, Taipei, Taiwan. (1994) |
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Publication |
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Publications 1. Hsu, J.Y., Bourguignon, L.Y., Adams, C.M., Peyrollier, K., Zhang, H., Fandel, T., Cun, C.L., Werb, Z., Noble-Haeusslein, L.J., 2008. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. Journal of Neuroscience 28, 13467-13477. 2. Hsu, J.Y., Stein, S.A., Xu, X.M., 2008. Abnormal growth of the corticospinal axons into the lumbar spinal cord of the hyt/hyt mouse with congenital hypothyroidism. Journal of Neuroscience Research 86, 3126-3139. 3. Hsu, J.Y., McKeon, R., Goussev, S., Werb, Z., Lee, J.U., Trivedi, A., Noble-Haeusslein, L.J., 2006. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. Journal of Neuroscience 26, 9841-9850. (Selected by the Editor as one of the only 4 articles highlighted with commentaries in the section “This Week in the Journal”) 4. Hsu, J.Y., Stein, S.A., Xu, X.M., 2006. Development of the corticospinal tract in the mouse spinal cord: a quantitative ultrastructural analysis. Brain Research 1084, 16-27. 5. Trivedi, A.A., Igarashi, T., Compagnone, N., Fan, X., Hsu, J.Y., Hall, D.E., John, C.M., Noble-Haeusslein, L.J., 2006. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Experimental Neurology 198, 88-100. 6. Hsu, J.Y., Stein, S.A., Xu, X.M., 2005. Temporal and spatial distribution of growth-associated molecules and astroglial cells in the rat corticospinal tract during development. Journal of Neuroscience Research 80, 330-340. 7. Hsu, J.Y., Xu, X.M., 2005. Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats. Journal of Neuroscience Research 82, 472-483. 8. *Trivedi, A., *Hsu, J.Y., Lin, Y., Goussev, S., Gan, J., Topp, K.S., Noble-Haeusslein, L.J., 2005. The effects of acute and extended inhibition of matrix metalloproteinases on demyelination and functional recovery after spinal cord injury. International Journal of Neuroprotection and Neuroregeneration 2, 30-38. (*Both authors had contributed equally to this article) 9. Goussev, S., Hsu, J.Y., Lin, Y., Tjoa, T., Maida, N., Werb, Z., Noble-Haeusslein, L.J., 2003. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. Journal of Neurosurgery (Spine) 99, 188-197. 10. Whetstone, W.D., Hsu, J.Y., Eisenberg, M., Werb, Z., Noble-Haeusslein, L.J., 2003. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. Journal of Neuroscience Research 74, 227-239.
Selected conference abstracts
1. Hsu, J.Y., Peyrollier, K., Bourguignon, L.Y.W., Noble-Haeusslein, L.J., Matrix metalloproteinase-9 as a modulator of astrocyte migration. 37th Annual Meeting of the Society for Neuroscience, San Diego, California, 2007 2. Hsu, J.Y., Noble-Haeusslein, L.J., Matrix metalloproteinase-2 deficiency affects astrocyte migration. 36th Annual Meeting of the Society for Neuroscience, Atlanta, Georgia, 2006. 3. Hsu, J.Y., Goussev, S., Werb, Z., Noble, L.J., Matrix metalloproteinase-2 deficient mice exhibit altered glial scar formation, impaired plasticity, and poor motor recovery after spinal cord injury. 23rd Annual National Neurotrauma Society Symposium, Washington, DC. 2005 4. Noble-Haeusslein, L.J., Hsu, J.Y., The effects of matrix metalloproteinase-2 (MMP-2) deficiency on contusive spinal cord injury. Gordon Research Conference, Big Sky, Montana, 2005. 5. Hsu, J.Y., Goussev, S., Trivedi, A., Werb, Z., Noble-Haeusslein, L.J., The role of matrix metalloproteinase-2 (MMP-2) following contusive spinal cord injury. 34th Annual Meeting of the Society for Neuroscience, San Diego, California, 2004. 6. Hsu, J.Y., Goussev, S., Werb, Z., Noble, L.J., Relationship between matrix metalloproteinases (MMPs), glial scar formation, and remodeling of extracellular matrix proteins after spinal cord injury. 33rd Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, 2003. 7. Goussev, S., Hsu, J.Y., Maida, N., Werb, Z., Noble, L.J., Differential temporal expression of matrix metalloproteinases during wound healing in a murine model of spinal cord injury. 20th Annual National Neurotrauma Society Symposium, Tempa Bay, Florida, 2002 8. Hsu, J.Y., Li, H., Lu, X., and Xu, X.M., Axonal outgrowth and expression of growth-related molecules in normal development and transplantation-induced regeneration in the rat spinal cord. 19th Annual National Neurotrauma Society Symposium, San Diego, California, 2001 9. Hsu, J.Y., Stein, S.A., Xu, X.M., Abnormal growth of corticospinal axons into the lumbar spinal cords of hyt/hyt mice with hypothyroidism. 73rd Annual Meeting of American Thyroid Association, Washington DC, 2001 10. Hsu, J.Y., Li, H., Lu, X., and Xu, X.M., Observation of initial axonal growth and glial responses following spinal cord hemisection and implantation of Schwann cell-seeded channels. 31st Annual Meeting of the Society for Neuroscience, San Diego, California, 2001, 11. Xu, X.M., Hsu, J.Y., Young, P.A., Temporal and spatial distributions of growth associated molecules and astroglia in the corticospinal tract of developing rats. 31st Annual Meeting of the Society for Neuroscience, San Diego, California, 2001 12. Hsu, J.Y., Li, H., Lu, X., and Xu, X.M., Embryonic neural cell adhesion molecule (E-NCAM) expressed during postnatal development of rat corticospinal tract and re-expressed by regenerating axons in Schwann cell-seeded guidance channel after spinal cord injury. 7th Annual Research Day Symposium, Graduate Student Association, St. Louis University, 2001, 13. Hsu, J.Y., Stein, S.A., Bailey, A.H., and Xu, X.M., Development of the corticospinal tract in hyt/hyt mice with congenital hypothyroidism. 30th Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, 2000 14. Hsu, J.Y., Stein, S.A., Biesiada, E., Julas, J., Bailey, N., and Xu, X.M., Quantitative analysis of the growth of corticospinal axons into cervical and lumbar spinal cords of developing mice. 29th Annual Meeting of the Society for Neuroscience, Miami Beach, Florida, 1999 |
