NCKU, Department of Cell Biology and Anatomy

SHUR-TZU CHEN

Education

· Sept 1974 ~ July 1978: National Taiwan Normal University, R.O.C., B.Sc.in Biology

· Aug 1990 ~ July 1992: Department of Histochemistry, Royal Postgraduate, Medical School, University of London, UK. Diploma in Neuroendocrine

· Aug 1992 ~ Dec 1994: Department of Anatomy, Charing Cross & Westminster Medical School (now Imperial College London), University of London, U.K., Ph.D. in Neuroscience. Thesis“The Retinal as a Model for Studying the Expression of Specific Gene Proteins during Development or under Experimental Conditions”

Address:

No.1, University Road, Tainan, TAIWAN

Department of Cell Biology and Anatomy, School of Medicine,

National Cheng-Kung University

 

To contact us:

Office: 886-6-2353535 ext 5299

Fax: 886-6-2093007

E-mail:  stchen@mail.ncku.edu.tw

 

Research Interests

· 神經細胞的發育、死亡與潰變

· Tumor suppressor and pro-apoptosis protein WOX1 in cell death

· WOX1 functions in neuronal disorders (AD & PD)

Professional Experiences

· Aug 1978 ~ July 1985: Biology and Chemistry Teacher

· WanLum Junior School in Pintumg, In High Senior School in Tainan, R.O.C.

· Aug 1985 ~ Sep 1989: Teaching Assistant Department of Anatomy, National Cheng Kung University, Medical College, R.O.C.

· Oct 1989 ~ July 1995: Instructor Department of Anatomy, National Cheng Kung University, Medical College, R.O.C.

· Aug 1995 ~ Present: Associate Professor Department of Anatomy, National Cheng Kung University, Medical College, R.O.C.

· Aug 2000 ~ 2003: Head, Graduate Institute of Cell Biology and Anatomy, NCKU

· The Association of Anatomists of the Republic of China

· International Society for Neurochemistry

Publication

近十年發表期刊論文 (* corresponding author)

1. Chen, S.T., A.J. Patel, L.J. Garey and L.S. Jen (1997) Expression of s-amyloid precursor protein immunoreactivity in the retina of the rat during normal development and after neonatal optic tract lesion. NeuroReport, 8: 713-717.

2. Chen, S.T.*, L.J. Garey and L.S. Jen (1997) Protein gene product 9.5 expression in retinal transplants. Biomed. Res., 18: 95-102.

3. Chen, S.T., J.P. Wang, C.H. Chien, and C.L. Shen (1997) Immunoreactivity of protein gene product 9.5 and synaptosomal-associated protein 25 in the retina of the Formosan Rock Monkey following optic nerve transection. Zool. Stud., 36: 333-339.

4. Chen, S.T., L.J. Garey, A.J. Patel, Q. Malih and L.S. Jen (1998) Factors that affect the expression of s-amyloid precursor protein immunoreactivity in the rat retina. J. Neuropath. Exp. Neurol., 57: 16-20.

5. Chen, S.T., L.J. Garey and L.S. Jen (1998) Immunoreactivity to synaptosomal-associated protein 25 in developing retinas: Effects of a glutamate agonist and retinal transplantation to a host brain. J. Brain Res. (J. Hirnforsch.), 39: 253-262.

6. Wang, J.P., S.M. Chuang, C.L. Shen and Chen, S.T.* (1998) Expression of Src family in the mouse developing nervous system. Biomed. Res., 19: 315-325.

7. Chen, S.T. and J.I. Chuang (1999) The antioxidant melatonin reduces cortical neuronal death after intrastriatal injection of kainate in the rat. Exp. Brain Res., 124: 241-247.

8. Chen, S.T., A. Jen, S.M. Gentleman and L.S. Jen (1999) Effects of bFGF and TGFs on the expression of amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina. NeuroReport, 10: 509-512.

9. Chen, S.T.*, J.P. Wang, C.L. Shen and L.S. Jen (1999) NADPH-diaphorase activity in normally developing and intracraninally transplanted retinas. Neurochem. Res., 24: 1053-1059.

10. Chen, S.T.*, J.P. Wang, L.J. Garey and L.S. Jen (1999) Expression of s-amyloid precursor protein and bcl-2 proto-oncogene proteins in rat retinas after intravitreal injection of aminoadipic acid. Neurochem. Int., 35: 371-382.

11. Wang, J.P., Chen, S.T.*, C.H. Chien, C.J. Yao and L.S. Chou (1999) Protein gene product 9.5-immunoreactive neurons in the retina of Striped Dolphin (Stenella coeru-leoalba) and Fraser Dolphin (Lagenodelphis hosei). Acta Anat. Nippon., 74: 441-446.

12. Chen, S.T., C.L. Shen, J.P. Wang and L.S. Chou (1999) A comparative study of neuropeptide Y immunoreactivity in the retina of dolphin and several other mammalian species. Zool. Stud., 38: 416-422.

13. Chen, S.T., J.P. Wang, C.H. Chien and C.L. Shen (1999) Differential expression of s-amyloid precursor and Bcl-2 proto-oncogene proteins in the developing dog retina. Neurosci. Res., 35: 265-271.

14. Chen, S.T., S.M. Chuang and J.P. Wang (1999) Src expression during murine development. Biomed. Res. 20: 259-272.

15. Chuang, J.I., S.T. Chen*, Y.H. Chang and L.S. Jen (2001) Alteration of Bcl-2 expression in the nigrostriatal pathway after kainate injection with or without melatonin co-treatment. J. Chem. Neuroanat. 21: 215-223.

16. Shen, C.L. and S.T. Chen* (2001) Distribution of ganglion cells and protein gene product 9.5 immunoreactivity in the developing and aging rat tongue. Biomed. Res. 22: 67-76.

17. Chuang, J.I. and S.T. Chen* (2002) Different expression of Bcl-2 and APP after intrastriatal injection of MPP+ in the rat. Neurochem. Int. 40: 169-179.

18. Chen, S.T., M.H. Hong, E.I.C Li and J.I. Chuang (2002) Melatonin attenuates MPP+-induced neurodegeneration glutathione impairment in the nigrostriatal dopaminergic pathway. J. Pineal Res. 32: 262-269.

19. Chuang J.I., M.S. Tsai, and S.T. Chen* (2002) Effects of intrathecal MPP+ injection on the expression of Alzheimer's disease associated proteins in nigrostriatal neurons. Biomed. Res. 23: 171-179.

20. Chen, S.T.*, J.R. Hsu, P.C. Hsu and J.I. Chuang (2003) The retina as a novel in vivo model for studying the role of molecules of the Bcl-2 family in relation to MPTP neurotoxicity. Neurochem. Res. 28(6): 805-814.

21. Wen Y. Y., T. Y.Chang, S. T. Chen, C. Li and H. S. Liu (2003) Comparative study of enterovirus 71 infection of human cell lines. J. Med. Virol. 70: 109-118.

22. Wu, C.W., C. Lin, C.J. Kuo, S.T. Chen, H.I. Chen, Y.M. Kuo (2003) Brain Region-dependent increases in -amyloid and apokopoprotein E levels in hypercholesterolemic rabbits. J. Neural. Transm. 110: 641-649.

23. Chang N.S., J. Doherty, A. Ensign, J. Lewis, J. Heath, L. Schultz, S.T. Chen and U. Oppermann (2003) Molecular mechanisms underlying WOXI activation during apoptotic and stress responses. Biochem. Pharmacol. 66:1347-1354.

24. Chen, S.T.*, J. I. Chuang, J. P. Wang, M. S. Tsai, H. Li and N. S. Chang (2004) Expression of WW domain-containing oxidoreductase WOX1 in developing murine nervous system. Neuroscience 124: 831-839.

25. Wu C. W., P. C. Liao, L. Yu, S. T. Wang, S. T. Chen, C. M. Wu, Y. M. Kuo (2004) Hemoglobin promotes Aβ oligomer formation and localizes in neurons and amyloid deposits. Neurobiol. Dis. 17: 367-377.

26. E.J. Lee, M.Y. Lee, H.Y. Chen, Y.S. Hsu, T.S. Wu, S.T. Chen, G.L. Chang (2005) Melatonin attenuates grey and white matter damage in a mouse model of transient focal cerebral ischemia. J. Pineal Res. 38:42-52.

27. Chen, S.T.*, J. I. Chuang, C. L. Cheng, L. J. Hsu, and N. S. Chang (2005) Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WOX1 in vivo. Neuroscience 130:397-407.

28. F.J. Lai, C.L. Cheng, S.T. Chen, C.H. Wu, M.C. Sheen, C.L. Shen, J.Y.Y. Lee, N.S. Chang, H.M. Sheu (2005) Protein expression of WW domain-containing oxidoreductase negatively correlates with the differentiation status of primary cutaneous squamous cell carcinoma: Blockade in translation from mRNA to protein. Clin. Cancer Res. 11:5769-5777.

29. S.P. Hung, J. R. Hsu, C. P. Lo, H.J. Huang, J. P. Wang, and S. T. Chen*. (2005) activation of extracellular signal-regulated kinases and induction of p21 and N-cadherin in genistein-induced neuronal differentiation. J. Cell. Biochem. 96:1061-1070.

30. Chen H.Y., Chen T.Y., Lee M.Y., Chen, S.T., Hsu Y.S., Kuo Y.L., Chang G.L., Wu T.S., Lee E.J. (2006) Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood-brain permeability after transient focal cerebral ischemia in mice. J. Pineal Res. 41:175-182.

31. Lee, M.Y., Y.H. Kuan, H.Y. Chen, T.Y. Chen, S.T. Chen, C.C. Hunag, I.P. Yang, Y.S. Hsu, T.S. Wu, E.J. Lee (2007) Intravenous administration with melatonin reduces intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. J. Pineal Res. 42:297-309.

32. Hsu L.J., S.T. Chen, M.Y. Li, F.J. Lai, H.M. Sheu, K. Van Moer, L. Schultz, J. Heath, Q. Hong, Y.S. Lin, and N.S. Chang, Cell surface hyaluronidase Hyal-2 is a cognate receptor for transforming growth factor β to activate tumor suppressor WWOX/FOR/WOX1 for regulating cell growth. EMBO J. (in revision)

33. Lo, L.J. Hsu, M.Y. Li, S.Y. Hsu, J.I .Chuang, M.S. Tsai, N.S. Chang, S.T. Chen*. Co-Activation of WW Domain-Containing Oxidoreductase WOX1 and JNK1 in MPP+-Induced Cell Death. Eur. J. Neurosci. (in revision)

Students

· 鄭敬俐 博士班學生 (成大基醫所, 2002~)

· 羅振鵬 博士班學生 (成大基醫所, 成大細胞生物與解剖所碩士班學生直升2003~)

· 蔡銘駿 博士班學生 (成大基醫所, 2003~ 休學中)

· 王憶華 博士班學生 (成大基醫所, 2007~)

 

· 許珮琪 碩士班學生 (成大細胞生物與解剖所, 2002年畢業) 神經毒素MPTP誘發的紋狀體黑質徑路之神經膠細胞反應

· 許景然 碩士班學生 (成大細胞生物與解剖所, 2002年畢業) 胞外訊息調控激脢參與在維他命A酸誘導之人類神經分化之研究

· 洪順培 碩士班學生 (成大生物學研究所, 2003年畢業) Genistein 誘發人類NTera 2細胞神經分化之研究

· 陳秀怡 碩士班學生 (成大細胞生物與解剖所, 2005年畢業) 探討Etoposide所誘導的神經細胞凋亡中WOX1 的角色之研究

· 李孟燕 碩士班學生 (成大生物學研究所, 2005年畢業) 坐骨神經傷害後WOX1蛋白在背根神經節的表現

· 洪純瑛 碩士班學生 (成大細胞生物與解剖所, 2006年畢業) 探討在心肌梗塞處理後WOX1和細胞凋亡蛋白在心肌組織中的表現情形及可能的調控機制

· 王憶華 碩士班學生 (成大細胞生物與解剖所, 2007年畢業)

　　探討褪黑激素在短暫局部腦缺血大白鼠模型中神經重塑的效果

· 陳建佑 碩士班學生 (成大細胞生物與解剖所, 2007年畢業)

· 李秋慧 碩士班學生 (成大細胞生物與解剖所, 2006--)

· 張立德 碩士班學生 (成大細胞生物與解剖所, 2006--)

· 曹智捷 碩士班學生 (成大細胞生物與解剖所, 2007--)

· 謝佳莉 碩士班學生 (成大細胞生物與解剖所, 2007--)

研究計劃

進行中之研究計劃

· The role of WW-domain containing oxidoreductase WOX1 in developing hearts and following cardiac infarction (國科會個人計劃 2007.8 - 2010.7)

· Signaling networks of WOX1 in the nervous system (國科會個人計劃 2003.8 - 2007.7；衛生署朴子醫院合作計劃200.6-2007.12)

· The role of WW-domain containing oxidoreductase WOX1 in the developing and injured nervous system (國科會個人計劃 2003.8 - 2007. 7)

近年完成之研究計劃

· Studies on the inflammatory reaction in the nigrostriatal pathway and retinal system following MPTP intoxication (國科會個人計劃 2000.8 - 2003. 7)

· Factors that regulate the synaptic plasticity of the visual system during normal development and under experimental conditions ( 教育部卓越計劃 2000.1-2003.12)