NCKU, Department of Cell Biology and Anatomy

Fan-E Mo

Education

· 1986 National Cheng Kung University, Chemistry, B.S.

· 1990 National Yang Ming University, Biochemistry, M.S.

· 2000 University of Illinois, Molecular Genetics, Ph.D.

Address:

No.1, University Road, Tainan, TAIWAN

Department of Cell Biology and Anatomy, School of Medicine,

National Cheng-Kung University

 

To contact us:

Office: 886-6-2353535 ext5293

Lab: 886-6-2353535

Fax: 886-6-2093007

E-mail: femo@mail.ncku.edu.tw

 

Research Interests

The research interests in this laboratory are focused on cardiac regeneration in heart failure from embryonic stem (ES) cells or other progenitor sources. The mechanism and signaling pathways in ES cell-fate determination are investigated in favor of driving cardiomyocyte differentiation. Factors and their signaling involved in regulation of cardiomyocyte apoptosis and scar tissue formation in damaged hearts are explored in hope of developing strategies to facilitate cardiac healing process. For a more long-term goal, a protocol to condition the ES cells to be more myocardium-driven will be developed and tested onto the mice with heart failure.

Professional Experiences

· 1991 Chia Nan University of Pharmacy & Science, Food Health, Lecturer

· 2001 University of Illinois, Biochem. & Mol. Genetics, Research Assistant Professor

· 08/2007 National Cheng Kung University, Cell Biology & Anatomy, Assistant Professor

Publication

1. Mo F.E, Lau L.F. (2006) The matricellular protein CCN1(CYR61) is essential for cardiac development. Circulation Research 99(9), 961-969.

2. Mo F.E, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF (2002) CYR61 (CCN1) is essential for placental development and vascular integrity. Mol.Cell. Biol. 22(24): 8709-8820.

3. Chen CC, Mo F.E, Lau LF (2001) The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J. Biol. Chem. 276(50):47329-47337.

4. Latinkic BV, Mo F.E, Greenspan JA, Copeland NG, Gilbert DJ, Jenkins NA, Ross SR, Lau LF. (2001) Promoter function of the angiogenic inducer Cyr61 gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element. ndocrinology 142(6): 2549-2557.

5. Kireeva ML, Mo, F.E, Yang GP, Lau LF. (1996) Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol. Cell. Biol. 16(4): 1326-1334.

6. Wang FF, Mo, F.E, Yen YT, Fong JC. (1991) Potentiation of thyrotropin-releasing hormone-stimulated prolactin mRNA levels in GH3 cells by acetylcholine. Mol. Cell. Endocrinol. 82(1): 117-123. 　

Presentations at conferences:

 

1. Mo F.E., Chen C.C, Lau L.F. (2008) The CCN1 action on cardiovascular cell survival. Basic Cardiovascular Sciences Conference 2008- Heart Failure: Molecular Mechanisms and Therapeutic Targets. Abstract #212 published in August 29, 2008 Circulation Research.

2. Chen C, Todorovic V, Chen N, Mo F.E, Lau LF. (2004) CCN1-integrin interactions in cell signaling. Third International Workshop on the CCN Family of Genes. Abstract.

3. Mo F.E, Muntean AG, Lau LF. (2003) CYR61 is essential for placental development and vascular integrity. Gordon Research Conferences in Vascular Cell Biology. Abstract.

4. Mo F.E, Muntean AG, Lau LF. (2003) CYR61 is essential for development: knockouts are embryonic lethal. The American Society for Cell Biology 43th Annual Meeting. Oral presentation.

5. Mo F.E, Muntean AG, Lau LF. (2002) CYR61 is essential for vascularization in placenta and for vascular integrity. The American Society of Hematology 44th Annual Meeting and Exposition. Oral presentation.

Students

蘇柏全—碩士班學生 (成大細胞生物與解剖所, 2007--)

邱靈音—碩士班學生 (成大細胞生物與解剖所, 2008--)

張鈺萱—碩士班學生 (成大細胞生物與解剖所, 2008--)

許哲裕—博士班學生