Michael Ming-Chiao Lai Tel: 886-6-2757575 ext.50000 FAX: 886-6-2743981 E-Mail: em50000@email.ncku.edu.tw  Education: 1968 M.D. Medicine NationalTaiwanUniversityCollege of Medicine, Taiwan, Republic of China 1973 Ph.D. Molecular Biology University of California, Berkeley, California 1973 Postdoctoral Molecular Biology University of California, Berkeley, California Academic Appointments: 2003-2006 Distinguished Research Fellow and Vice President, Academia Sinica 2002-2007 Distinguished Professor, University of Southern California 1990-2003 Investigator, Howard Hughes Medical Institute 1988 Visiting Professor, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 1983-2002 Professor, Department of Molecular Microbiology and Immunology (formerly Microbiology) and Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 1981-1983 Associate Professor, Department of Neurology, University of Southern CaliforniaSchool of Medicine, Los Angeles, California 1978-1983 Associate Professor, Department of Microbiology, University of Southern CaliforniaSchool of Medicine, Los Angeles, California 1973-1978 Assistant Professor, Department of Microbiology, University of Southern CaliforniaSchool of Medicine, Los Angeles, California Awards: 1968 M.D., Summa cum Laude, NationalTaiwanUniversityCollege of Medicine, Taiwan 1985 USC Phi Kappa Phi Award for Scientific Work, Honorable Mention 1986 International Scientist Fellowship from Japan Society for the Promotion of Science 1987,1994 American Society for Microbiology Foundation Lecturer 1987 National Multiple Sclerosis Society Established Investigator 1989 Burlington Northern Foundation Faculty Achievement Award for Outstanding Scholar 1990 Howard Hughes Medical Institute Investigator Award 1990 American Society for Microbiology, RNA Virus Divisional Lecturer 1990 Society of Chinese Bioscientists in America, CathayHospital Award on Hepatitis Research 1992 Academician, Academia Sinica (NationalAcademy of Sciences), Taiwan 1994-95 American Society for Microbiology, Foundation Lecturer 1995 USCSchool of Medicine Excellence in Teaching Award, Class of 1997 1995 Outstanding Alumnus Award (Inaugural), Tainan First High School, Taiwan 1996 Chinese-American Faculty Association of Southern California, Achievement Award 1997 Phi Tau Phi Scholastic Honor Society of America 1998 USC Associates Award for Creativity in Research and Scholarship 2001 Distinguished Professor, University of Southern California 2001 ¡§Highly Cited Researcher¡¨, Institute of Scientific Information 2002 Hastings Foundation Professor, University of Southern California 2002 Fellow, AmericanAcademy of Microbiology 2003 Taiwanese-American Foundation Science-Technology Award 2004 Doctor Honoris Causa, The Central University, Taiwan 2004 ¡§Highly Cited Researcher¡¨ (1981-2000), Institute of Scientific Information 2006 TWAS Fellow, The Academy of Sciences for the Developing World Publications (The past 3 years): Kawamura H, Govindarajan S, Aswad F, Machida K, Lai MM, Sung VM, Dennert G. (2006) HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice. Hepatology. 44, 936-44. Macnaughton TB, Lai MM. (2006) HDV RNA replication: ancient relic or primer? Curr Top Microbiol Immunol. 307, 25-45. Review. Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM. (2006) Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol. 80, 7199-207. Li YJ, Macnaughton T, Gao L, Lai MM. (2006) RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies. J Virol. 80, 6478-86. Yu GY, Lee KJ, Gao L, Lai MM. (2006) Palmitoylation and polymerization of hepatitis C virus NS4B protein. J Virol. 80, 6013-23. Choi SH, Park KJ, Ahn BY, Jung G, Lai MM, Hwang SB. (2006) Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase. Mol Cell Biol. 26, 3048-59. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 103, 1828-33. Machida K, Cheng KT, Sung VM, Levine AM, Foung S, Lai MM. (2006) Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol. 80, 866-74. Lai MM. (2005) RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus. J Virol. 79, 7951-8. Review. Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM, Miyamura T, Moriishi K, Matsuura Y. (2005) Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. J Virol. 79, 13473-82. ChoiKS, Aizaki H, Lai MM. (2005) Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release. J Virol.79, 9862-71. Machida K, Cheng KT, Pavio N, Sung VM, Lai MM.(2005) Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol. 79, 8079-89. Shi S.T., Lai M.M.C. (2005) Viral and cellular proteins involved in coronavirus replication. Curr. To.p Microbiol. Immunol. 287, 95-131. Review. Yu G.Y., Lai M.M.C. (2005) The ubiquitin-proteasome system facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry. J. Virol. 79, 644-648. Lai, M.M.C. (2005) RNA replication without RNA-dependent RNA polymerase: Surprises from hepatitis delta virus. J. Virol. (minireview) 79, 7951-7958. Choi K.S., Mizutani A., Lai M.M.C. (2004) SYNCRIP, a member of the heterogeneous nuclear ribonucleoprotein family, is involved in mouse hepatitis virus RNA synthesis. J. Virol. 78, 13153-13162. Vo N.V., Tuler J.R., Lai M.M.C. (2004) Enzymatic characterization of the full-length and C-terminally truncated hepatitis C virus RNA polymerases: function of the last 21 amino acids of the C terminus in template binding and RNA synthesis. Biochemistry 43, 10579-10591. Machida K., Cheng K.T., Sung V.M., Lee K.J., Levine A.M., Lai M.M.C. (2004) Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes. J. Virol. 78, 8835-8843. Aizaki H., Lee K.J., Sung V.M., Ishiko H., Lai M.M.C. (2004) Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts. Virology 324, 450-461. Lee K.J., Choi J., Ou J.H., Lai M.M.C. (2004) Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. J Virol. 78, 3480-3488. Machida K., Cheng K.T., Sung V.M., Shimodaira S., Lindsay K.L., Levine A.M., Lai M.Y., Lai M.M.C. (2004) Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc. Natl. Acad. Sci. U S A 101, 4262-4267. Li Y.J., Stallcup M.R., Lai M.M.C. (2004) Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol. 78, 13325-13334.