賴明詔 院士

• 聯絡電話：(06)2757575轉50000
• 傳真號碼：(06)2743981
• E-mail： em50000@email.ncku.edu.tw

• 台灣大學醫學院醫科學士 (1968)
• 美國加州大學柏克萊校區博士 (1973)

• 美國南加州大學助理教授(1973-1978)
• 美國南加州大學副教授(1978-1983)
• 美國南加州大學教授(1983-2002)
• 美國南加州大學卓越教授 (2002-2007)
• 中央研究院訪問教授 (1988)
• 美國Howard Hughes Medical Institute正研究員(1990-2003)
• 中央研究院分子生物研究所特聘研究員兼副院長(2003-2006)

• 北柏林頓基金會傑出學者獎(1989)
• 美洲華人生物科學家學會－國泰醫院肝炎研究獎(1990)
• 中央研究院院士(1992)
• 美國南加大協會學術成就與研究創新獎(1998)
• 美國微生物學院院士(2002)
• 美國南加州大學傑出教授(2002)
• 台美基金會科技工程人才成就獎(2003)
• 國立中央大學名譽博士(2004)
• 美國科學資訊所公佈從1981年到2000年論文最被高度引用的研究者(2004)
• 發展中世界科學院院士(2006)
• 傑出人才基金會傑出人才獎(2007)
• 美國南加大終身成就獎(2008)
  

1. Machida K, Kondo Y, Huang J, Chen YC, Cheng KT, Keck Z, Foung S, Dubuisson J, Sung VM, Lai MM.(2008) HCV-induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein. J Virol. (2008) Apr 16.
2. Aizaki H, Morikawa K, Fukasawa M, Hara H, Inoue Y, Tani H, Saito K, Nishijima M, Hanada K, Matsuura Y, Lai MM, Miyamura T, Wakita T, Suzuki T.(2008) A Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection. J Virol. (2008) Mar 26.
3. Keck ZY, Machida K, Lai MM, Ball JK, Patel AH, Foung SK. (2008) Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies. Curr Top Microbiol Immunol. (2008); 317:1-38.
4. Lai CK, Jeng KS, Machida K, Cheng YS, Lai MM. (2008) Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology. (2008) Jan 20; 370:295-309.
5. Kondo Y, Sung VM, Machida K, Liu M, Lai MM. (2007) Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines. Virology. 2007; 361:161-73.
6. Choi J, Forman HJ, Ou JH, Lai MM, Seronello S, Nandipati A. (2006) Redox modulation of the hepatitis C virus replication complex is calcium dependent.Free Radic Biol Med. 2006; 41:1488-98.
7. Kawamura H, Govindarajan S, Aswad F, Machida K, Lai MM, Sung VM, Dennert G. (2006) HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice. Hepatology. 44, 936-44.
8. Macnaughton TB, Lai MM. (2006) HDV RNA replication: ancient relic or primer? Curr Top Microbiol Immunol. 307, 25-45. Review.
9. Machida K, Cheng KT, Lai CK, Jeng KS, Sung VM, Lai MM. (2006) Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J Virol. 80, 7199-207.
10. Li YJ, Macnaughton T, Gao L, Lai MM. (2006) RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies. J Virol. 80, 6478-86.
11. Yu GY, Lee KJ, Gao L, Lai MM. (2006) Palmitoylation and polymerization of hepatitis C virus NS4B protein. J Virol. 80, 6013-23.
12. Choi SH, Park KJ, Ahn BY, Jung G, Lai MM, Hwang SB. (2006) Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase. Mol Cell Biol. 26, 3048-59.
13. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 103, 1828-33.
14. Machida K, Cheng KT, Sung VM, Levine AM, Foung S, Lai MM. (2006) Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol. 80, 866-74.
15. Lai MM. (2005) RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus. J Virol. 79, 7951-8. Review.
16. Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM, Miyamura T, Moriishi K, Matsuura Y. (2005) Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. J Virol. 79, 13473-82.
17. Choi KS, Aizaki H, Lai MM. (2005) Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release. J Virol.79, 9862-71.
18. Machida K, Cheng KT, Pavio N, Sung VM, Lai MM. (2005) Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol. 79, 8079-89.
19. Shi S.T., Lai M.M.C. (2005) Viral and cellular proteins involved in coronavirus replication. Curr. To.p Microbiol. Immunol. 287, 95-131. Review.
20. Yu G.Y., Lai M.M.C. (2005) The ubiquitin-proteasome system facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry. J. Virol. 79, 644-648.
21. Lai, M.M.C. (2005) RNA replication without RNA-dependent RNA polymerase: Surprises from hepatitis delta virus. J. Virol. (minireview) 79, 7951-7958.

成功大學秉承全台首府的傳統，以國際性的全方位大學為目標，培育有人文與專業素養、創意與國際觀及關懷社會的領袖人才，並發展跨領域的研究特色，回饋社會及造福人類。